Correlation between parameters of volumetric capnography and spirometry during a submaximal exercise protocol on a treadmill in patients with cystic fibrosis and healthy controls

Correlation between parameters of volumetric capnography and spirometry during a submaximal exercise protocol on a treadmill in patients with cystic fibrosis and healthy controls

Spirometry is the most frequently used test to evaluate the progression of lung damage in cystic fibrosis (CF). However, there has been low sensitivity in detecting early lung changes. In this context, our objective was to identify the correlation between parameters of volumetric capnography (VCap)...

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Bibliographic Details
Published in:Pulmonology Vol. 25; no. 1; pp. 21 - 31
Main Authors: Parazzi, P.L.F., Marson, F.A.L., Ribeiro, M.A.G.O., Schivinski, C.I.S., Ribeiro, J.D.
Format: Journal Article
Language:English
Published: Spain Elsevier España, S.L.U 01-01-2019
Taylor & Francis
Subjects:
Capnography
Exercise test
Lung function
Spirometry
RR
Spirometry
slope 3/VT
CFG
CO2
HR
VTalv
Lung function
VCO2
6-MWT
BMI
CF
CG
VD/VT
SpO2
IT
Exercise test
VD
ET
PetCO2
EV
FVC
VCap
slope 2
Capnography
slope 3
slope 3/PetCO2
FEV1
slope 2/VT
CFTR
VT
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Summary:Spirometry is the most frequently used test to evaluate the progression of lung damage in cystic fibrosis (CF). However, there has been low sensitivity in detecting early lung changes. In this context, our objective was to identify the correlation between parameters of volumetric capnography (VCap) and spirometric parameters during a submaximal treadmill exercise test. A cross-sectional and controlled study which included 64 patients with CF (CFG) and 64 healthy control subjects (CG) was performed. The CFG was from a university hospital and the CG from local schools. All participants underwent spirometry and VCap before, during and after the submaximal treadmill exercise test. The main variable analyzed by VCap was the slope of phase 3 (slope 3), which indicates the [exhaled carbon dioxide] at the end of expiration, and expresses the heterogeneity of gas emptying in pulmonary periphery. The correlation analysis between spirometry and VCap was conducted using the Spearman correlation test, considering α=0.05. The indices analyzed by VCap showed correlation with parameters of VCap. Slope 3 showed an inverse correlation with forced expiratory volume in the first second of forced vital capacity (FEV1) in both groups and at all moments of the submaximal treadmill exercise test. Forced vital capacity (FVC) and FEV1/FVC ratio showed an inverse correlation with slope 3 only for CFG. Values of slope 3 corrected by the spontaneous tidal volume (VT) and end-tidal carbon dioxide tension (PetCO2) showed results similar to slope 3 analyzed separately. Parameters of VCap such as slope 3, slope 3/VT and slope 3/PetCO2 correlated with sensitive variables of spirometry such as FEV1, FVC and FEV1/FVC ratio. For the evaluated variables, there was consistency in the correlation between the two tests, which may indicate the impact of CF on pulmonary physiology.
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ISSN:2531-0437
2531-0437
DOI:10.1016/j.pulmoe.2018.04.006