Search Results - "Parashar, Abhinav"

Murburn Precepts for Cytochrome P450 Mediated Drug/Xenobiotic Metabolism and Homeostasis by Parashar, Abhinav, Manoj, Kelath M

“…We aim to demonstrate why deeming diffusible reactive oxygen species (DROS) as toxic wastes do not afford a comprehensive understanding of cytochrome P450…”
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What is the Role of Lipid Membrane-embedded Quinones in Mitochondria and Chloroplasts? Chemiosmotic Q-cycle versus Murburn Reaction Perspective by Manoj, Kelath Murali, Gideon, Daniel Andrew, Parashar, Abhinav

“…Quinones are found in the lipid membranes of prokaryotes like E. coli and cyanobacteria, and are also abundant in eukaryotic mitochondria and chloroplasts…”
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Editorial: Drug metabolism-induced organ toxicity by Kadi, Adnan A, Li, Yang, Parashar, Abhinav, Attwa, Mohamed W

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Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses by Parashar, Abhinav, Gideon, Daniel Andrew, Manoj, Kelath Murali

“…Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term “murburn” is…”
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The curious case of benzbromarone: insight into super-inhibition of cytochrome P450 by Parashar, Abhinav, Gade, Sudeep Kumar, Potnuru, Mahesh, Madhavan, Nandita, Manoj, Kelath Murali

“…Cytochrome P450 (CYP) family of redox enzymes metabolize drugs and xenobiotics in liver microsomes. Isozyme CYP2C9 is reported to be inhibited by benzbromarone…”
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Acute toxicity of cyanide in aerobic respiration: Theoretical and experimental support for murburn explanation by Manoj, Kelath Murali, Ramasamy, Surjith, Parashar, Abhinav, Gideon, Daniel Andrew, Soman, Vidhu, Jacob, Vivian David, Pakshirajan, Kannan

“…The inefficiency of cyanide/HCN (CN) binding with heme proteins (under physiological regimes) is demonstrated with an assessment of thermodynamics, kinetics,…”
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Nano-TiO 2 enhances biofilm formation in a bacterial isolate from activated sludge of a waste water treatment plant by Mathur, Ankita, Parashar, Abhinav, Chandrasekaran, N., Mukherjee, Amitava

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Decreased Phototoxic Effects of TiO₂ Nanoparticles in Consortium of Bacterial Isolates from Domestic Waste Water by Mathur, Ankita, Kumari, Jyoti, Parashar, Abhinav, T, Lavanya, Chandrasekaran, N, Mukherjee, Amitava

“…This study is aimed to explore the toxicity of TiO2 nanoparticles at low concentrations (0.25, 0.50 & 1.00 μg/ml); on five bacterial isolates and their…”
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Deciphering the influence of soil and feed on the nutritional status of ruminants in rainfed areas using metagenomic analysis by Raju, N. Venkata, Sunny, Jithin S., Gideon, Daniel Andrew, Sukumar, Karuganti, Riaz, Safia, Nawaz, Sarfraz, Syed, Asad, Eswaramoorthy, Rajalakshmanan, Pankaj, Prabhat Kumar, Parashar, Abhinav

“…The soil–plant-animal continuum is an emerging domain in biological research and hence, to ascertain this aspect, the present study was conducted in three…”
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Low Power Mixed-Signal SoC Integration and Verification Challenges with Third Party IP Cores by Shankar, Ruchi, Mishra, Prachi, Parashar, Abhinav, Padoor, Ashwini, Balasubramanian, Lakshmanan

“…IP reuse is all about improving productivity and can result in significantly shrinking the design cycle time especially with configurable third party IP cores…”
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Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein by Parashar, Abhinav, Bak, Kyoungmi, Murshed, Monzur

“…Inactivating mutations in matrix Gla protein (MGP) lead to Keutel syndrome, a rare disease hallmarked by ectopic calcification of cartilage and vascular…”
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Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein by Parashar, Abhinav, Bak, Kyoungmi, Murshed, Monzur

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An inducible model for medial calcification based on matrix Gla protein deficiency by Bak, Kyoungmi, Parashar, Abhinav, Allgayer, Raphaela, Marulanda, Juliana, Gourgas, Ophélie, Cerruti, Marta, Murshed, Monzur

“…Calcific deposits in the arterial media have been associated with a number of metabolic and genetic disorders including diabetes, chronic kidney disease and…”
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Murburn precepts for lactic‐acidosis, Cori cycle, and Warburg effect: Interactive dynamics of dehydrogenases, protons, and oxygen by Manoj, Kelath Murali, Nirusimhan, Vijay, Parashar, Abhinav, Edward, Jesucastin, Gideon, Daniel Andrew

“…It is unresolved why lactate is transported to the liver for further utilization within the physiological purview of Cori cycle, when muscles have more lactate…”
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Hemoglobin catalyzes ATP-synthesis in human erythrocytes: a murburn model by Parashar, Abhinav, Jacob, Vivian David, Gideon, Daniel Andrew, Manoj, Kelath Murali

“…Blood hemoglobin (Hb), known to transport oxygen, is the most abundant globular protein in humans. Erythrocytes have ∼10 −3 M concentration of ATP in…”
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The physiological role of complex V in ATP synthesis: Murzyme functioning is viable whereas rotary conformation change model is untenable by Manoj, Kelath Murali, Bazhin, Nikolai Mikhailovich, Tamagawa, Hirohisa, Jaeken, Laurent, Parashar, Abhinav

“…Complex V or F o F 1 -ATPase is a multimeric protein found in bioenergetic membranes of cells and organelles like mitochondria/chloroplasts. The popular…”
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Traces of certain drug molecules can enhance heme-enzyme catalytic outcomes by Parashar, Abhinav, Manoj, Kelath Murali

“…► Known- dapsone and amiodarone enhance liver microsomal heme-enzyme activity. ► Effect of these molecules on various functionally unrelated heme-enzymes was…”
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Differential effects of P25 TiO2 nanoparticles on freshwater green microalgae: Chlorella and Scenedesmus species by Roy, Rajdeep, Parashar, Abhinav, Bhuvaneshwari, M., Chandrasekaran, N., Mukherjee, Amitava

“…•Differential effects of P25 TiO2 NPs on Chlorella and Scenedesmus.•Concentration dependent effects in morphology and viability.•Increased ROS, catalase…”
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Cyanide does more to inhibit heme enzymes, than merely serving as an active-site ligand by Parashar, Abhinav, Venkatachalam, Avanthika, Gideon, Daniel Andrew, Manoj, Kelath Murali

“…•Cyanide (CN) is a well-studied toxic principle, known to inhibit heme-enzymes.•Inhibition is supposed to result from CN binding at the active site as a…”
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Aerobic respiration: proof of concept for the oxygen-centric murburn perspective by Manoj, Kelath Murali, Parashar, Abhinav, David Jacob, Vivian, Ramasamy, Surjith

“…The inner mitochondrial membrane protein complexes (I-V) and prokaryotic respiratory machinery are examined for a deeper understanding of their…”
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