Search Results - "Paras, Nick A."

Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments by Merz, Gregory E., Chalkley, Matthew J., Tan, Sophia K., Tse, Eric, Lee, Joanne, Prusiner, Stanley B., Paras, Nick A., DeGrado, William F., Southworth, Daniel R.

“…Accumulation of filamentous aggregates of tau protein in the brain is a pathological hallmark of Alzheimer’s disease (AD) and many other neurodegenerative…”
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Selectivity in the Addition of Electron‐Deficient Radicals to the C2 Position of Indoles by Li, Yi, Vaz, Roy J., Olson, Steven H., Munson, Mark, Paras, Nick A., Conrad, Jay

“…The addition of electron‐deficient radicals to the C2 position of indoles has been described in the literature as opposed to electrophilic addition at the C3…”
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Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent by Nguyen, Terrence-Thang H, O'Brien, Connor J, Tran, Minh L N, Olson, Steven H, Settineri, Nicholas S, Prusiner, Stanley B, Paras, Nick A, Conrad, Jay

“…The development of a water-soluble iridium catalyst enables the trifluoromethylation of polar small molecules and peptides in DMSO solution or aqueous media…”
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New Strategies in Organic Catalysis:  The First Enantioselective Organocatalytic Friedel−Crafts Alkylation by Paras, Nick A, MacMillan, David W. C

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Silver Benzoate Facilitates the Copper-Catalyzed C–N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles by Lozano, Cedric, Ramirez, Cristian, Sin, Ny, Viart, Hélène M.-F, Prusiner, Stanley B, Paras, Nick A, Conrad, Jay

“…In the literature, C–N coupling methods for the reaction of iodo-oxazole with 2-pyridinone were found to be low yielding. C–N coupling using silver benzoate…”
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Model of P‑Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs by Conrad, Jay, Paras, Nick A., Vaz, Roy J.

“…The blood–brain barrier (BBB) poses a significant obstacle in developing therapeutics for neurodegenerative diseases and central nervous system (CNS)…”
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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy by Ayers, Jacob I, Lee, Joanne, Monteiro, Octovia, Woerman, Amanda L, Lazar, Ann A, Condello, Carlo, Paras, Nick A, Prusiner, Stanley B

“…The α-synuclein protein can adopt several different conformations that cause neurodegeneration. Different α-synuclein conformers cause at least three distinct…”
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Cryo‐ EM structure of a novel α‐synuclein filament subtype from multiple system atrophy by Yan, Nicholas L., Candido, Francisco, Tse, Eric, Melo, Arthur A., Prusiner, Stanley B., Mordes, Daniel A., Southworth, Daniel R., Paras, Nick A., Merz, Gregory E.

“…Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by accumulation of α‐synuclein cross‐β amyloid filaments in the brain…”
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Photoredox Cyanomethylation of Indoles: Catalyst Modification and Mechanism by O’Brien, Connor J, Droege, Daniel G, Jiu, Alexander Y, Gandhi, Shivaani S, Paras, Nick A, Olson, Steven H, Conrad, Jay

“…The direct cyanomethylation of indoles at the 2- or 3-position was achieved via photoredox catalysis. The versatile nitrile synthon is introduced as a radical…”
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Selectivity in the Addition of Electron Deficient Radicals to the C 2 Position of Indoles by Li, Yi, Vaz, Roy J, Olson, Steven H, Munson, Mark, Paras, Nick A, Conrad, Jay

“…The addition of electron deficient radicals to the position of indoles has been described in the literature as opposed to electrophilic addition at the 3…”
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Convenient Route to Secondary Sulfinates: Application to the Stereospecific Synthesis of α‑C‑Chiral Sulfonamides by Johnson, Michael G, Gribble, Michael W, Houze, Jonathan B, Paras, Nick A

“…A convenient synthesis of α-chiral sulfinates from readily available precursors has been accomplished via the corresponding heterocyclic thioethers and…”
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The Enantioselective Organocatalytic 1,4-Addition of Electron-Rich Benzenes to α,β-Unsaturated Aldehydes by Paras, Nick A, MacMillan, David W. C

“…The first enantioselective organocatalytic alkylation of electron-rich benzene rings with α,β-unsaturated aldehydes has been accomplished. The use of iminium…”
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Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline by Smith, Adrian L, DeMorin, Frenel F, Paras, Nick A, Huang, Qi, Petkus, Jeffrey K, Doherty, Elizabeth M, Nixey, Thomas, Kim, Joseph L, Whittington, Douglas A, Epstein, Linda F, Lee, Matthew R, Rose, Mark J, Babij, Carol, Fernando, Manory, Hess, Kristen, Le, Quynh, Beltran, Pedro, Carnahan, Josette

“…The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is…”
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A process for the rapid removal of dialkylamino-substituents from aromatic rings. Application to the expedient synthesis of ( R)-tolterodine by Paras, Nick A., Simmons, Bryon, MacMillan, David W.C.

“…A range of N, N-dialkylanilines have been successfully converted to the parent substituted benzenes by a novel two-step pathway. The products are obtained in…”
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Discovery of 4‑Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity by Grandjean, Jean-Marc M, Jiu, Alexander Y, West, John W, Aoyagi, Atsushi, Droege, Daniel G, Elepano, Manuel, Hirasawa, Makoto, Hirouchi, Masakazu, Murakami, Ryo, Lee, Joanne, Sasaki, Koji, Hirano, Shimpei, Ohyama, Takao, Tang, Benjamin C, Vaz, Roy J, Inoue, Masahiro, Olson, Steven H, Prusiner, Stanley B, Conrad, Jay, Paras, Nick A

“…Tau prions feature in the brains of patients suffering from Alzheimer’s disease and other tauopathies. For the development of therapeutics that target the…”
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Trans-channel fluorescence learning improves high-content screening for Alzheimer’s disease therapeutics by Wong, Daniel R., Conrad, Jay, Johnson, Noah R., Ayers, Jacob, Laeremans, Annelies, Lee, Joanne C., Lee, Jisoo, Prusiner, Stanley B., Bandyopadhyay, Sourav, Butte, Atul J., Paras, Nick A., Keiser, Michael J.

“…In microscopy-based drug screens, fluorescent markers carry critical information on how compounds affect different biological processes. However, practical…”
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C 2 -Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl−Ene Reactions with Glyoxylate and Pyruvate Esters by Evans, David A, Tregay, Steven W, Burgey, Christopher S, Paras, Nick A, Vojkovsky, Tomas

“…The C 2 -symmetric complexes [Cu(S,S)-tert-butylbis(oxazolinyl)](SbF6)2 (2a), its bis(aquo) counterpart [Cu(S,S)-tert-butylbis(oxazolinyl)(H2O)2](SbF6)2 (4),…”
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C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Enantioselective Catalysis of the Glyoxylate−Ene Reaction by EVANS, David A., BURGEY, Christopher S., PARAS, Nick A., VOJKOVSKY, Tomas, TREGAY, Steven W.

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C 2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Enantioselective Catalysis of the Glyoxylate−Ene Reaction by Evans, David A, Burgey, Christopher S, Paras, Nick A, Vojkovsky, Tomas, Tregay, Steven W

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C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl−Ene Reactions with Glyoxylate and Pyruvate Esters by EVANS, David A., TREGAY, Steven W., BURGEY, Christopher S., PARAS, Nick A., VOJKOVSKY, Tomas

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