Search Results - "Parapini, S"

Plasmodium falciparum parasitized red blood cells modulate the production of endothelin-1 by human endothelial cells by Basilico, N, Mondani, M, Parapini, S, Speciale, L, Ferrante, P, Taramelli, D

“…Plasmodium falciparum (P. falciparum) malaria is the most important parasitic infection of humans, responsible for about 2,000,000 deaths every year…”
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Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network by Basilico, N, Bosisio, E, Buelli, F, Campiani, G, Casagrande, M, Castelli, F, Coghi, P, Corbett, Y, Cortelezzi, L, D'Alessandro, S, Dell'Agli, M, Esposito, F, Fattorusso, C, Fattorusso, E, Finaurini, S, Galli, G V, Gemma, S, Habluetzel, A, Lucantoni, L, Melato, S, Monti, D, Olliaro, P, Omodeo-Salè, F, Parapini, S, Persico, M, Rizzi, M, Romeo, S, Rossi, F, Rusconi, C, Sparatore, A, Scafati, O Taglialatela, van den Bogaart, E, Taramelli, D, Vaiana, N, Yerbanga, S

“…Clinical treatment-failures to affordable drugs encouraged new investigation for discovery and development of new prophylactic and therapeutic interventions…”
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In vitro Multistage Malaria Transmission Blocking Activity of Selected Malaria Box Compounds by Malebo, Hamisi M, D'Alessandro, Sarah, Ebstie, Yehenew A, Sorè, Harouna, Tenoh Guedoung, Alain R, Katani, Shaaban J, Parapini, Silvia, Taramelli, Donatella, Habluetzel, Annette

“…Continuous efforts into the discovery and development of new antimalarials are required to face the emerging resistance of the parasite to available…”
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Structure−Activity Relationships in 4-Aminoquinoline Antiplasmodials. The Role of the Group at the 7-Position by Kaschula, Catherine H, Egan, Timothy J, Hunter, Roger, Basilico, Nicoletta, Parapini, Silvia, Taramelli, Donatella, Pasini, Erica, Monti, Diego

“…Antiplasmodial activities versus the chloroquine sensitive D10 strain of Plasmodium falciparum of a series of N ,N 1-diethyl-N…”
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Ultrastructural characteristics, biological activity and pharmacological relevance of synthetic malaria pigment (beta-haematin) by Taramelli, D, Monti, D, Omodeo-Salè, F, Basilico, N, Parapini, S, Pasini, E, Lombardi, L, Olliaro, P

“…Malaria pigment (haemozoin, HZ) is the detoxification product of haemoglobin-derived haem of intraerythrocytic malaria parasites. At schizont rupture,…”
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A fine balance between oxidised and reduced haem controls the survival of intraerythrocytic plasmodia by Taramelli, D, Monti, D, Basilico, N, Parapini, S, Omodeo-Salé, F, Olliaro, P

“…The polymerisation of haemoglobin-derived ferri-protoporphyrin IX (Fe(III)PPIX) to haemozoin (malaria pigment) is a crucial process for intraerythrocytic…”
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Endoperoxide Derivatives from Marine Organisms:  1,2-Dioxanes of the Plakortin Family as Novel Antimalarial Agents by Fattorusso, Caterina, Campiani, Giuseppe, Catalanotti, Bruno, Persico, Marco, Basilico, Nicoletta, Parapini, Silvia, Taramelli, Donatella, Campagnuolo, Claudio, Fattorusso, Ernesto, Romano, Adriana, Taglialatela-Scafati, Orazio

“…Plakortin (1) is a remarkably simple 1,2-dioxane derivative, extracted from the marine sponge Plakortis simplex, showing a submicromolar activity against…”
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4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity by Sparatore, Anna, Basilico, Nicoletta, Parapini, Silvia, Romeo, Sergio, Novelli, Federica, Sparatore, Fabio, Taramelli, Donatella

“…A set of quinolizidinyl and quinolizidinylalkyl derivatives of 4-amino-7-chloroquinoline and of 9-amino-6-chloro-2-methoxyacridine were prepared and tested in…”
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Synthesis of Some Cryptolepine Analogues, Assessment of Their Antimalarial and Cytotoxic Activities, and Consideration of Their Antimalarial Mode of Action by Onyeibor, Onyeka, Croft, Simon L, Dodson, Hilary I, Feiz-Haddad, Mohammad, Kendrick, Howard, Millington, Nicola J, Parapini, Silvia, Phillips, Roger M, Seville, Scott, Shnyder, Steven D, Taramelli, Donatella, Wright, Colin W

“…A series of analogues of cryptolepine (1) have been synthesized and evaluated for their in vitro antiplasmodial and cytotoxic properties. The IC50 values of…”
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Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum by Omodeo-Salè, Fausta, Motti, Anna, Basilico, Nicoletta, Parapini, Silvia, Olliaro, Piero, Taramelli, Donatella

“…Red blood cells infected withPlasmodium falciparum(IRBCs) undergo changes primarily in their membrane composition that contribute to malaria pathogenesis…”
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Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin by Parapini, Silvia, Basilico, Nicoletta, Mondani, Monica, Olliaro, Piero, Taramelli, Donatella, Monti, Diego

“…The role of haem iron (II) and oxidative stress in the activation and antimalarial activity of artemisinin is unclear. Thus, we submitted malaria parasite to…”
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Artemisinin antimalarials do not inhibit hemozoin formation by Haynes, Richard K, Monti, Diego, Taramelli, Donatella, Basilico, Nicoletta, Parapini, Silvia, Olliaro, Piero

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Antimalarial Polyketide Cycloperoxides from the Marine Sponge Plakortis simplex by Campagnuolo, Claudio, Fattorusso, Ernesto, Romano, Adriana, Taglialatela‐Scafati, Orazio, Basilico, Nicoletta, Parapini, Silvia, Taramelli, Donatella

“…Abstract Three new ( 5 – 7 ) and two known ( 4 and 8 ) polyketide derivatives have been isolated from the Caribbean sponge Plakortis simplex . Their…”
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Activity against Plasmodium falciparum of cycloperoxide compounds obtained from the sponge Plakortis simplex by Fattorusso, Ernesto, Parapini, Silvia, Campagnuolo, Claudio, Basilico, Nicoletta, Taglialatela-Scafati, Orazio, Taramelli, Donatella

“…There is an urgent need to discover new antimalarials, due to the spread of chloroquine resistance and the limited number of available drugs. In the last few…”
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Damicoside from Axinella damicornis:  The Influence of a Glycosylated Galactose 4-OH Group on the Immunostimulatory Activity of α-Galactoglycosphingolipids by COSTANTINO, Valeria, D'ESPOSITO, Monica, FATTORUSSO, Ernesto, MANGONI, Alfonso, BASILICO, Nicoletta, PARAPINI, Silvia, TARAMELLI, Donatella

“…Alpha-galactoglycosphingolipids (alpha-GalGSLs) are unique immunostimulatory glycosphingolipids from marine sponges. Analysis of the glycosphingolipid…”
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High Antiplasmodial Activity of Novel Plasmepsins I and II Inhibitors by Dell'Agli, Mario, Parapini, Silvia, Galli, Germana, Vaiana, Nadia, Taramelli, Donatella, Sparatore, Anna, Liu, Peng, Dunn, Ben M, Bosisio, Enrica, Romeo, Sergio

“…The aim of this study was to develop new antiplasmodial compounds acting through distinct mechanisms during both the liver and the blood stages of the parasite…”
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Synthesis and antimalarial activities of some furoxan sulfones and related furazans by Galli, Ubaldina, Lazzarato, Loretta, Bertinaria, Massimo, Sorba, Giovanni, Gasco, Alberto, Parapini, Silvia, Taramelli, Donatella

“…Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and…”
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Plasmepsin II inhibition and antiplasmodial activity of Primaquine–Statine `double-drugs by Romeo, Sergio, Dell'Agli, Mario, Parapini, Silvia, Rizzi, Luca, Galli, Germana, Mondani, Monica, Sparatore, Anna, Taramelli, Donatella, Bosisio, Enrica

“…Graphic Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the `double-drug' approach. The IC 50 values for…”
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Immunomodulatory α-Galactoglycosphingolipids: Synthesis of a 2′-O-Methyl-α-Gal-GSL and Evaluation of Its Immunostimulating Capacity by Barbieri, Lucia, Costantino, Valeria, Fattorusso, Ernesto, Mangoni, Alfonso, Aru, Elisabetta, Parapini, Silvia, Taramelli, Donatella

“…The total synthesis of 1‐2‐docosanoylamino‐O‐(2‐O‐methyl‐α‐D‐galactopyranosyl)‐1,3,4‐octadecanetriol (2), a 2′‐methoxy analog of the immunostimulating…”
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Standardization of the Physicochemical Parameters to Assess in Vitro the β-Hematin Inhibitory Activity of Antimalarial Drugs by Parapini, Silvia, Basilico, Nicoletta, Pasini, Erica, Egan, Timothy J, Olliaro, Piero, Taramelli, Donatella, Monti, Diego

“…Parapini, S., Basilico, N., Pasini, E., Egan, T. J., Olliaro, P., Taramelli, D., and Monti, D. 2000. Standardization of the physicochemical parameters to…”
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