Search Results - "Paramio, Jesus M."

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models by Carnero, Amancio, Paramio, Jesus M

“…When PI3K (phosphatidylinositol-3 kinase) is activated by receptor tyrosine kinases, it phosphorylates PIP2 to generate PIP3 and activates the signaling…”
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NOTCH pathway inactivation promotes bladder cancer progression by Maraver, Antonio, Fernandez-Marcos, Pablo J, Cash, Timothy P, Mendez-Pertuz, Marinela, Dueñas, Marta, Maietta, Paolo, Martinelli, Paola, Muñoz-Martin, Maribel, Martínez-Fernández, Mónica, Cañamero, Marta, Roncador, Giovanna, Martinez-Torrecuadrada, Jorge L, Grivas, Dimitrios, de la Pompa, Jose Luis, Valencia, Alfonso, Paramio, Jesús M, Real, Francisco X, Serrano, Manuel

“…NOTCH signaling suppresses tumor growth and proliferation in several types of stratified epithelia. Here, we show that missense mutations in NOTCH1 and NOTCH2…”
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EZH2 in Bladder Cancer, a Promising Therapeutic Target by Martínez-Fernández, Mónica, Rubio, Carolina, Segovia, Cristina, López-Calderón, Fernando F, Dueñas, Marta, Paramio, Jesús M

“…Bladder Cancer (BC) represents a current clinical and social challenge. The recent studies aimed to describe the genomic landscape of BC have underscored the…”
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CD44v6, STn & O-GD2: promising tumor associated antigens paving the way for new targeted cancer therapies by Lodewijk, Iris, Dueñas, Marta, Paramio, Jesus M., Rubio, Carolina

“…Targeted therapies are the state of the art in oncology today, and every year new Tumor-associated antigens (TAAs) are developed for preclinical research and…”
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CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status by Rubio, Carolina, Martínez-Fernández, Mónica, Segovia, Cristina, Lodewijk, Iris, Suarez-Cabrera, Cristian, Segrelles, Carmen, López-Calderón, Fernando, Munera-Maravilla, Ester, Santos, Mirentxu, Bernardini, Alejandra, García-Escudero, Ramón, Lorz, Corina, Gómez-Rodriguez, Maria José, de Velasco, Guillermo, Otero, Irene, Villacampa, Felipe, Guerrero-Ramos, Felix, Ruiz, Sergio, de la Rosa, Federico, Domínguez-Rodríguez, Sara, Real, Francisco X, Malats, Núria, Castellano, Daniel, Dueñas, Marta, Paramio, Jesus M

“…Bladder cancer is a clinical and social problem due to its high incidence and recurrence rates. It frequently appears in elderly patients showing other medical…”
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G9a inhibition by CM-272: Developing a novel anti-tumoral strategy for castration-resistant prostate cancer using 2D and 3D in vitro models by Moreira-Silva, Filipa, Outeiro-Pinho, Gonçalo, Lobo, João, Guimarães, Rita, Gaspar, Vítor M., Mano, João F., Agirre, Xabier, Pineda-Lucena, António, Prosper, Felipe, Paramio, Jesus M., Henrique, Rui, Correia, Margareta P., Jerónimo, Carmen

“…Castration-resistant prostate cancer (CRPC) is an incurable form of prostate cancer (PCa), with DNMT1 and G9a being reported as overexpressed, rendering them…”
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PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors by Dueñas, Marta, Martínez-Fernández, Mónica, García-Escudero, Ramón, Villacampa, Felipe, Marqués, Miriam, Saiz-Ladera, Cristina, Duarte, José, Martínez, Victor, Gómez, Mª José, Martín, Mª Luisa, Fernández, Manoli, Castellano, Daniel, Real, Francisco X., Rodriguez-Peralto, Jose L., De La Rosa, Federico, Paramio, Jesús M.

“…Bladder cancer (BC) is the fifth most common cancer in the world, being the non‐muscle invasive tumors (NMIBC) the most frequent. NMIBC shows a very high…”
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Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer by Martínez-Fernández, Mónica, Feber, Andrew, Dueñas, Marta, Segovia, Cristina, Rubio, Carolina, Fernandez, Maria, Villacampa, Felipe, Duarte, José, López-Calderón, Fernando F, Gómez-Rodriguez, Ma José, Castellano, Daniel, Rodriguez-Peralto, Jose L, de la Rosa, Federico, Beck, Stephan, Paramio, Jesús M

“…Long non-coding RNAs (lncRNAs) have been claimed as key molecular players in gene expression regulation, being involved in diverse epigenetic processes. They…”
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Deregulated Activity of Akt in Epithelial Basal Cells Induces Spontaneous Tumors and Heightened Sensitivity to Skin Carcinogenesis by SEGRELLES, Carmen, LU, Jerry, BELTRAN, Linda, MARTINEZ-CRUZ, Ana Belén, GARCIA-ESCUDERO, Ramon, LORZ, Corina, RUIZ, Sergio, BRAVO, Ana, PARAMIO, Jesus M, DIGIOVANNI, John, HAMMANN, Brian, SANTOS, Mirentxu, MORAL, Marta, CASCALLANA, José Luis, FERNANDA LARA, M, RHO, Okkyung, CARBAJAL, Steve, TRAAG, Jeanine

“…Aberrant activation of the phosphoinositide-3-kinase (PI3K)/PTEN/Akt pathway, leading to increased proliferation and decreased apoptosis, has been implicated…”
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Impaired hair growth and wound healing in mice lacking thyroid hormone receptors by Contreras-Jurado, Constanza, García-Serrano, Laura, Martínez-Fernández, Mónica, Ruiz-Llorente, Lidia, Paramio, Jesus M, Aranda, Ana

“…Both clinical and experimental observations show that the skin is affected by the thyroidal status. In hypothyroid patients the epidermis is thin and alopecia…”
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Akt Activation Synergizes with Trp53 Loss in Oral Epithelium to Produce a Novel Mouse Model for Head and Neck Squamous Cell Carcinoma by MORAL, Marta, SEGRELLES, Carmen, COSTA, Clotilde, SAIZ, Cristina, RODRIGUEZ-PERALTO, Jose L, MARTINEZ-TELLO, Francisco J, RODRIGUEZ-PINILLA, Maria, SANCHEZ-CESPEDES, Montserrat, GARIN, Marina, GRANDE, Teresa, BRAVO, Ana, DIGIOVANNI, John, LARA, M. Fernanda, PARAMIO, Jesús M, MARTINEZ-CRUZ, Ana Belén, LORZ, Corina, SANTOS, Mirentxu, GARCIA-ESCUDERO, Ramón, LU, Jerry, KIGUCHI, Kaoru, BUITRAGO, Agueda

“…Head and neck squamous cell carcinoma (HNSCC) is a common human neoplasia with poor prognosis and survival that frequently displays Akt overactivation. Here we…”
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Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies by Carvalho, Sandra, Abreu, Catarina M, Ferreira, Dylan, Lima, Luís, Ferreira, José A, Santos, Lúcio L, Ribeiro, Ricardo, Grenha, Vânia, Martínez-Fernández, Mónica, Duenas, Marta, Suárez-Cabrera, Cristian, Paramio, Jesus M, Diéguez, Lorena, Freitas, Paulo P, Oliveira, Marta I

“…Bladder cancer is the most common malignancy of the urinary tract, having one of the highest recurrence rates and progression from non-muscle to muscle…”
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The thyroid hormone receptors modulate the skin response to retinoids by García-Serrano, Laura, Gomez-Ferrería, María Ana, Contreras-Jurado, Constanza, Segrelles, Carmen, Paramio, Jesus M, Aranda, Ana

“…Retinoids play an important role in skin homeostasis and when administered topically cause skin hyperplasia, abnormal epidermal differentiation and…”
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Cell Therapies in Bladder Cancer Management by Morales, Lucia, Paramio, Jesús M

“…Currently, bladder cancer (BC) represents a challenging problem in the field of Oncology. The high incidence, prevalence, and progression of BC have led to the…”
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Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression by Segovia, Cristina, San José-Enériz, Edurne, Munera-Maravilla, Ester, Martínez-Fernández, Mónica, Garate, Leire, Miranda, Estíbaliz, Vilas-Zornoza, Amaia, Lodewijk, Iris, Rubio, Carolina, Segrelles, Carmen, Valcárcel, Luis Vitores, Rabal, Obdulia, Casares, Noelia, Bernardini, Alejandra, Suarez-Cabrera, Cristian, López-Calderón, Fernando F., Fortes, Puri, Casado, José A., Dueñas, Marta, Villacampa, Felipe, Lasarte, Juan José, Guerrero-Ramos, Félix, de Velasco, Guillermo, Oyarzabal, Julen, Castellano, Daniel, Agirre, Xabier, Prósper, Felipe, Paramio, Jesús M.

“…Bladder cancer is lethal in its advanced, muscle-invasive phase with very limited therapeutic advances 1 , 2 . Recent molecular characterization has defined…”
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Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis by Lara, M. Fernanda, García-Escudero, Ramón, Ruiz, Sergio, Santos, Mirentxu, Moral, Marta, Martínez-Cruz, Ana B., Segrelles, Carmen, Lorz, Corina, Paramio, Jesús M.

“…The epidermal‐specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in…”
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The transcriptional co-activator YAP: A new player in head and neck cancer by Segrelles, Carmen, Paramio, Jesús M., Lorz, Corina

“…The activation of the Hippo pathway effector Yes-associated protein (YAP) is modulated by different upstream cues. Phosphorylated YAP accumulates in the…”
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Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling by Segrelles, Carmen, Moral, Marta, Lorz, Corina, Santos, Mirentxu, Lu, Jerry, Cascallana, José Luis, Lara, M Fernanda, Carbajal, Steve, Martínez-Cruz, Ana Belén, García-Escudero, Ramón, Beltran, Linda, Segovia, José C, Bravo, Ana, DiGiovanni, John, Paramio, Jesús M

“…Aberrant activation of the Akt pathway has been implicated in several human pathologies including cancer. However, current knowledge on the involvement of Akt…”
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BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer by Martínez, Víctor G, Rubio, Carolina, Martínez-Fernández, Mónica, Segovia, Cristina, López-Calderón, Fernando, Garín, Marina I, Teijeira, Alicia, Munera-Maravilla, Ester, Varas, Alberto, Sacedón, Rosa, Guerrero, Félix, Villacampa, Felipe, de la Rosa, Federico, Castellano, Daniel, López-Collazo, Eduardo, Paramio, Jesús M, Vicente, Ángeles, Dueñas, Marta

“…Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence…”
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Liquid Biopsy Biomarkers in Bladder Cancer: A Current Need for Patient Diagnosis and Monitoring by Lodewijk, Iris, Dueñas, Marta, Rubio, Carolina, Munera-Maravilla, Ester, Segovia, Cristina, Bernardini, Alejandra, Teijeira, Alicia, Paramio, Jesús M, Suárez-Cabrera, Cristian

“…Bladder Cancer (BC) represents a clinical and social challenge due to its high incidence and recurrence rates, as well as the limited advances in effective…”
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