Search Results - "Paramio, Jesús"

Cell Therapies in Bladder Cancer Management by Morales, Lucia, Paramio, Jesús M

“…Currently, bladder cancer (BC) represents a challenging problem in the field of Oncology. The high incidence, prevalence, and progression of BC have led to the…”
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Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression by Segovia, Cristina, San José-Enériz, Edurne, Munera-Maravilla, Ester, Martínez-Fernández, Mónica, Garate, Leire, Miranda, Estíbaliz, Vilas-Zornoza, Amaia, Lodewijk, Iris, Rubio, Carolina, Segrelles, Carmen, Valcárcel, Luis Vitores, Rabal, Obdulia, Casares, Noelia, Bernardini, Alejandra, Suarez-Cabrera, Cristian, López-Calderón, Fernando F., Fortes, Puri, Casado, José A., Dueñas, Marta, Villacampa, Felipe, Lasarte, Juan José, Guerrero-Ramos, Félix, de Velasco, Guillermo, Oyarzabal, Julen, Castellano, Daniel, Agirre, Xabier, Prósper, Felipe, Paramio, Jesús M.

“…Bladder cancer is lethal in its advanced, muscle-invasive phase with very limited therapeutic advances 1 , 2 . Recent molecular characterization has defined…”
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The transcriptional co-activator YAP: A new player in head and neck cancer by Segrelles, Carmen, Paramio, Jesús M., Lorz, Corina

“…The activation of the Hippo pathway effector Yes-associated protein (YAP) is modulated by different upstream cues. Phosphorylated YAP accumulates in the…”
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BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer by Martínez, Víctor G, Rubio, Carolina, Martínez-Fernández, Mónica, Segovia, Cristina, López-Calderón, Fernando, Garín, Marina I, Teijeira, Alicia, Munera-Maravilla, Ester, Varas, Alberto, Sacedón, Rosa, Guerrero, Félix, Villacampa, Felipe, de la Rosa, Federico, Castellano, Daniel, López-Collazo, Eduardo, Paramio, Jesús M, Vicente, Ángeles, Dueñas, Marta

“…Bladder cancer is a current clinical and social problem. At diagnosis, most patients present with nonmuscle-invasive tumors, characterized by a high recurrence…”
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Liquid Biopsy Biomarkers in Bladder Cancer: A Current Need for Patient Diagnosis and Monitoring by Lodewijk, Iris, Dueñas, Marta, Rubio, Carolina, Munera-Maravilla, Ester, Segovia, Cristina, Bernardini, Alejandra, Teijeira, Alicia, Paramio, Jesús M, Suárez-Cabrera, Cristian

“…Bladder Cancer (BC) represents a clinical and social challenge due to its high incidence and recurrence rates, as well as the limited advances in effective…”
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DNA Methylation as a Therapeutic Target for Bladder Cancer by Nunes, Sandra P, Henrique, Rui, Jerónimo, Carmen, Paramio, Jesús M

“…Bladder cancer (BC) is the tenth most frequent cancer worldwide and is associated with high mortality when diagnosed in its most aggressive form, which is not…”
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The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops by Menacho-Márquez, Mauricio, García-Escudero, Ramón, Ojeda, Virginia, Abad, Antonio, Delgado, Pilar, Costa, Clotilde, Ruiz, Sergio, Alarcón, Balbino, Paramio, Jesús M, Bustelo, Xosé R

“…The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells…”
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Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion by Ganuza, Miguel, Sáiz-Ladera, Cristina, Cañamero, Marta, Gómez, Gonzalo, Schneider, Ralph, Blasco, María A, Pisano, David, Paramio, Jesús M, Santamaría, David, Barbacid, Mariano

“…Cyclin‐dependent kinase (Cdk)7, the catalytic subunit of the Cdk‐activating kinase (CAK) complex has been implicated in the control of cell cycle progression…”
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PARP inhibition promotes endothelial‐like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry by Fernández‐Cortés, Mónica, Delgado‐Bellido, Daniel, Bermúdez‐Jiménez, Eloísa, Paramio, Jesús M, O'Valle, Francisco, Vinckier, Stefan, Carmeliet, Peter, Garcia‐Diaz, Angel, Oliver, F Javier

“…Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop pseudovascular structures without the participation of endothelial…”
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Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway by García-Escudero, Ramón, Segrelles, Carmen, Dueñas, Marta, Pombo, María, Ballestín, Claudio, Alonso-Riaño, Marina, Nenclares, Pablo, Álvarez-Rodríguez, Roberto, Sánchez-Aniceto, Gregorio, Ruíz-Alonso, Ana, López-Cedrún, José Luis, Paramio, Jesús M., Lorz, Corina

“…We have shown that in HNSCC tumors high expression of PIK3CA is a poor prognosis factor. Increased gene expression leads to augmented level of the p110α…”
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Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes by Lázaro, Sara, Pérez-Crespo, Miriam, Lorz, Corina, Bernardini, Alejandra, Oteo, Marta, Enguita, Ana Belén, Romero, Eduardo, Hernández, Pilar, Tomás, Laura, Morcillo, Miguel Ángel, Paramio, Jesús M., Santos, Mirentxu

“…High-grade neuroendocrine lung malignancies (large-cell neuroendocrine cell carcinoma, LCNEC, and small-cell lung carcinoma, SCLC) are among the most deadly…”
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Tackling tumor microenvironment through epigenetic tools to improve cancer immunotherapy by Lodewijk, Iris, Nunes, Sandra P, Henrique, Rui, Jerónimo, Carmen, Dueñas, Marta, Paramio, Jesús M

“…Epigenetic alterations are known contributors to cancer development and aggressiveness. Additional to alterations in cancer cells, aberrant epigenetic marks…”
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BlaDimiR: A Urine-based miRNA Score for Accurate Bladder Cancer Diagnosis and Follow-up by Suarez-Cabrera, Cristian, Estudillo, Lidia, Ramón-Gil, Erik, Martínez-Fernández, Mónica, Peral, Jorge, Rubio, Carolina, Lodewijk, Iris, Martín de Bernardo, Álvaro, García-Escudero, Ramón, Villacampa, Felipe, Duarte, José, de la Rosa, Federico, Castellano, Daniel, Guerrero-Ramos, Félix, Real, Francisco X., Malats, Núria, Paramio, Jesús M., Dueñas, Marta

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Competitive Repopulation Assay of Long-Term Epidermal Stem Cell Regeneration Potential by Segrelles, Carmen, Santos-de-Frutos, Karla, Paramio, Jesús M, Lorz, Corina

“…Epidermal stem cells are responsible for normal tissue homeostasis and contribute to tissue regeneration during injury. Several assays measuring stem cell…”
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Bosutinib Inhibits EGFR Activation in Head and Neck Cancer by Segrelles, Carmen, Contreras, David, Navarro, Elena M, Gutiérrez-Muñoz, Carmen, García-Escudero, Ramón, Paramio, Jesús M, Lorz, Corina

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and although new therapeutic approaches have been recently evaluated,…”
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The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells by Citterio, Carmen, Menacho-Márquez, Mauricio, García-Escudero, Ramón, Larive, Romain M, Barreiro, Olga, Sánchez-Madrid, Francisco, Paramio, Jesús M, Bustelo, Xosé R

“…The guanosine triphosphatases of the Rho and Rac subfamilies regulate protumorigenic pathways and are activated by guanine nucleotide exchange factors (Rho…”
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Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma by Lázaro, Sara, Lorz, Corina, Enguita, Ana Belén, Seller, Iván, Paramio, Jesús M., Santos, Mirentxu

“…Lung cancer remains the leading cause of cancer deaths worldwide. Among the Non-Small Cell Carcinoma (NSCLC) category, Adenocarcinoma (ADC) represents the most…”
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A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer by Suárez-Cabrera, Cristian, Quintana, Rita M, Bravo, Ana, Casanova, M Llanos, Page, Angustias, Alameda, Josefa P, Paramio, Jesús M, Maroto, Alicia, Salamanca, Javier, Dupuy, Adam J, Ramírez, Angel, Navarro, Manuel

“…RAS genes are mutated in 20% of human tumors, but these mutations are very rare in breast cancer. Here, we used a mouse model to generate tumors upon…”
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Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms by Lorenzo-Martín, L. Francisco, Citterio, Carmen, Menacho-Márquez, Mauricio, Conde, Javier, Larive, Romain M., Rodríguez-Fdez, Sonia, García-Escudero, Ramón, Robles-Valero, Javier, Cuadrado, Myriam, Fernández-Pisonero, Isabel, Dosil, Mercedes, Sevilla, María A., Montero, María J., Fernández-Salguero, Pedro M., Paramio, Jesús M., Bustelo, Xosé R.

“…The bidirectional regulation of epithelial–mesenchymal transitions (EMT) is key in tumorigenesis. Rho GTPases regulate this process via canonical pathways that…”
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Gene Expression Analyses in Non Muscle Invasive Bladder Cancer Reveals a Role for Alternative Splicing and Tp53 Status by Dueñas, Marta, Pérez-Figueroa, Andrés, Oliveira, Carla, Suárez-Cabrera, Cristian, Sousa, Abel, Oliveira, Patricia, Villacampa, Felipe, Paramio, Jesús M., Martínez-Fernández, Mónica

“…Non-muscle invasive bladder cancer (NMIBC) represents a crucial problem for the national health care systems due to its high rates of recurrence and the…”
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