Search Results - "Parada, Luis"

Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells by Chen, Jian, McKay, Renée M., Parada, Luis F.

“…Eighty percent of malignant tumors that develop in the central nervous system are malignant gliomas, which are essentially incurable. Here, we discuss how…”
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The paraventricular thalamus controls a central amygdala fear circuit by Penzo, Mario A., Robert, Vincent, Tucciarone, Jason, De Bundel, Dimitri, Wang, Minghui, Van Aelst, Linda, Darvas, Martin, Parada, Luis F., Palmiter, Richard D., He, Miao, Huang, Z. Josh, Li, Bo

“…Inhibiting projections from the paraventricular nucleus of the thalamus to a specific division of the amygdala prevents fear conditioning in mice, indicating…”
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Cell of origin of glioma: biological and clinical implications by Alcantara Llaguno, Sheila R, Parada, Luis F

“…The cellular origin of gliomas remains a topic of controversy in cancer research. Advances in neurobiology, molecular genetics, and functional genomics have…”
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A restricted cell population propagates glioblastoma growth after chemotherapy by Chen, Jian, Li, Yanjiao, Yu, Tzong-Shiue, McKay, Renée M., Burns, Dennis K., Kernie, Steven G., Parada, Luis F.

“…By using a GFP reporter protein expressed selectively in neural stem cells in a mouse model of glioblastoma, a small subset of GFP-positive glioma cells is…”
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Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes by Alcantara Llaguno, Sheila R., Wang, Zilai, Sun, Daochun, Chen, Jian, Xu, Jing, Kim, Euiseok, Hatanpaa, Kimmo J., Raisanen, Jack M., Burns, Dennis K., Johnson, Jane E., Parada, Luis F.

“…A central question in glioblastoma multiforme (GBM) research is the identity of the tumor-initiating cell, and its contribution to the malignant phenotype and…”
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Cell of origin for malignant gliomas and its implication in therapeutic development by Zong, Hui, Parada, Luis F, Baker, Suzanne J

“…Malignant glioma remains incurable despite tremendous advancement in basic research and clinical practice. The identification of the cell(s) of origin should…”
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Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy by Xie, Xuanhua P., Laks, Dan R., Sun, Daochun, Ganbold, Mungunsarnai, Wang, Zilai, Pedraza, Alicia M., Bale, Tejus, Tabar, Viviane, Brennan, Cameron, Zhou, Xiuping, Parada, Luis F.

“…We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-proliferative therapies. Functional characterization of…”
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Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma by Shi, Yufeng, Lim, S. Kyun, Liang, Qiren, Iyer, Swathi V., Wang, Hua-Yu, Wang, Zilai, Xie, Xuanhua, Sun, Daochun, Chen, Yu-Jung, Tabar, Viviane, Gutin, Philip, Williams, Noelle, De Brabander, Jef K., Parada, Luis F.

“…Cancer-specific inhibitors that reflect the unique metabolic needs of cancer cells are rare. Here we describe Gboxin, a small molecule that specifically…”
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A Robust Method for the Elaboration of SiO2-Based Colloidal Crystals as a Template for Inverse Opal Structures by Fookes, Federico, Polo Parada, Luis, Fidalgo, María

“…Photonic crystals (PCs) are nanomaterials with photonic properties made up of periodically modulated dielectric materials that reflect light between a…”
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Cell-of-origin susceptibility to glioblastoma formation declines with neural lineage restriction by Alcantara Llaguno, Sheila, Sun, Daochun, Pedraza, Alicia M., Vera, Elsa, Wang, Zilai, Burns, Dennis K., Parada, Luis F.

“…The contribution of lineage identity and differentiation state to malignant transformation is controversial. We have previously shown that adult neural stem…”
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CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors by Mo, Wei, Chen, Jian, Patel, Amish, Zhang, Liang, Chau, Vincent, Li, Yanjiao, Cho, Woosung, Lim, Kyun, Xu, Jing, Lazar, Alexander J., Creighton, Chad J., Bolshakov, Svetlana, McKay, Renée M., Lev, Dina, Le, Lu Q., Parada, Luis F.

“…Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that arise in connective tissue surrounding peripheral nerves. They occur…”
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TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response by Ma, Zhenzhong, Zang, Tong, Birnbaum, Shari G., Wang, Zilai, Johnson, Jane E., Zhang, Chun-Li, Parada, Luis F.

“…Adult neurogenesis persists in the rodent dentate gyrus and is stimulated by chronic treatment with conventional antidepressants through BDNF/TrkB signaling…”
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Cancer stem cells in gliomas: evolving concepts and therapeutic implications by Alcantara Llaguno, Sheila, Parada, Luis F.

“…Cancer stem cells (CSCs) have been implicated in the hierarchical heterogeneity and treatment resistance of hematologic and solid tumor malignancies, including…”
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ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae by Elefteriou, Florent, Benson, M. Douglas, Sowa, Hideaki, Starbuck, Michael, Liu, Xiuyun, Ron, David, Parada, Luis F., Karsenty, Gerard

“…The transcription factor ATF4 enhances bone formation by favoring amino acid import and collagen synthesis in osteoblasts, a function requiring its…”
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Brain Tumor Stem Cells Remain in Play by Parada, Luis F, Dirks, Peter B, Wechsler-Reya, Robert J

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Cell Lineage-Based Stratification for Glioblastoma by Wang, Zilai, Sun, Daochun, Chen, Yu-Jung, Xie, Xuanhua, Shi, Yufeng, Tabar, Viviane, Brennan, Cameron W., Bale, Tejus A., Jayewickreme, Chenura D., Laks, Dan R., Alcantara Llaguno, Sheila, Parada, Luis F.

“…Glioblastoma, the predominant adult malignant brain tumor, has been computationally classified into molecular subtypes whose functional relevance remains to be…”
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Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice by Zhou, Jing, Blundell, Jacqueline, Ogawa, Shiori, Kwon, Chang-Hyuk, Zhang, Wei, Sinton, Christopher, Powell, Craig M, Parada, Luis F

“…PTEN (phosphatase and tensin homolog deleted on chromosome ten) is a lipid phosphatase that counteracts the function of phosphatidylinositol-3 kinase (PI3K)…”
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Tumor progression is independent of tumor-associated macrophages in cell lineage-based mouse models of glioblastoma by Chipman, Mollie E, Wang, Zilai, Sun, Daochun, Pedraza, Alicia M, Bale, Tejus A, Parada, Luis F

“…Macrophage targeting therapies have had limited clinical success in glioblastoma (GBM). Further understanding the GBM immune microenvironment is critical for…”
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Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model by Alcantara Llaguno, Sheila, Chen, Jian, Kwon, Chang-Hyuk, Jackson, Erica L., Li, Yanjiao, Burns, Dennis K., Alvarez-Buylla, Arturo, Parada, Luis F.

“…Malignant astrocytomas are infiltrative and incurable brain tumors. Despite profound therapeutic implications, the identity of the cell (or cells) of origin…”
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Vision protection and robust axon regeneration in glaucoma models by membrane-associated Trk receptors by Nishijima, Euido, Honda, Sari, Kitamura, Yuta, Namekata, Kazuhiko, Kimura, Atsuko, Guo, Xiaoli, Azuchi, Yuriko, Harada, Chikako, Murakami, Akira, Matsuda, Akira, Nakano, Tadashi, Parada, Luis F., Harada, Takayuki

“…Activation of neurotrophic factor signaling is a promising therapy for neurodegeneration. However, the transient nature of ligand-dependent activation limits…”
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