Search Results - "Parackal, Sarah"

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma by Duchatel, Ryan J, Jackson, Evangeline R, Parackal, Sarah G, Kiltschewskij, Dylan, Findlay, Izac J, Mannan, Abdul, Staudt, Dilana E, Thomas, Bryce C, Germon, Zacary P, Laternser, Sandra, Kearney, Padraic S, Jamaluddin, M Fairuz B, Douglas, Alicia M, Beitaki, Tyrone S, McEwen, Holly P, Persson, Mika L, Hocke, Emily A, Jain, Vaibhav, Aksu, Michael, Manning, Elizabeth E, Murray, Heather C, Verrills, Nicole M, Sun, Claire Xin, Daniel, Paul, Vilain, Ricardo E, Skerrett-Byrne, David A, Nixon, Brett, Hua, Susan, de Bock, Charles E, Colino-Sanguino, Yolanda, Valdes-Mora, Fatima, Tsoli, Maria, Ziegler, David S, Cairns, Murray J, Raabe, Eric H, Vitanza, Nicholas A, Hulleman, Esther, Phoenix, Timothy N, Koschmann, Carl, Alvaro, Frank, Dayas, Christopher V, Tinkle, Christopher L, Wheeler, Helen, Whittle, James R, Eisenstat, David D, Firestein, Ron, Mueller, Sabine, Valvi, Santosh, Hansford, Jordan R, Ashley, David M, Gregory, Simon G, Kilburn, Lindsay B, Nazarian, Javad, Cain, Jason E, Dun, Matthew D

“…Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma - DIPG), are uniformly fatal brain tumors that lack…”
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Comparison of Roche Cell-Free DNA collection Tubes® to Streck Cell-Free DNA BCT®s for sample stability using healthy volunteers by Parackal, Sarah, Zou, Donghui, Day, Robert, Black, Michael, Guilford, Parry

“…To compare the Roche Cell-Free DNA Collection Tubes® against the Streck Cell-Free DNA BCT®s for sample stability using Cell Free DNA (cfDNA) from healthy…”
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Abstract 3029: Functional genomics pipeline reveals therapeutic dependencies in diffuse intrinsic pontine glioma by Parackal, Sarah, Bradshaw, Gabrielle, Sun, Claire, Chong, Wai Chin, Daniel, Paul, Jayasekara, Samantha, Crombie, Duncan, Firestein, Ron, Cain, Jason

“…Abstract Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive and infiltrative pediatric brainstem tumor with universal lethality. Current treatment…”
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ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma by Jackson, Evangeline R, Duchatel, Ryan J, Staudt, Dilana E, Persson, Mika L, Mannan, Abdul, Yadavilli, Sridevi, Parackal, Sarah, Game, Shaye, Chong, Wai Chin, Jayasekara, W Samantha Nilanthi, Le Grand, Marion, Kearney, Padraic S, Douglas, Alicia M, Findlay, Izac J, Germon, Zacary P, McEwen, Holly P, Beitaki, Tyrone S, Patabendige, Adjanie, Skerrett-Byrne, David A, Nixon, Brett, Smith, Nathan D, Day, Bryan, Manoharan, Neevika, Nagabushan, Sumanth, Hansford, Jordan R, Govender, Dinisha, McCowage, Geoffrey B, Firestein, Ron, Howlett, Meegan, Endersby, Raelene, Gottardo, Nicholas G, Alvaro, Frank, Waszak, Sebastian M, Larsen, Martin R, Colino-Sanguino, Yolanda, Valdés-Mora, Fatima, Rakotomalala, Andria, Meignan, Samuel, Pasquier, Eddy, Andre, Nicolas, Hulleman, Esther, Eisenstat, David D, Vitanza, Nicholas A, Nazarian, Javad, Koschmann, Carl, Mueller, Sabine, Cain, Jason E, Dun, Matthew D

“…Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are the most lethal of childhood cancers. Palliative radiotherapy is the…”
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Circulating tumor DNA is a sensitive marker for routine monitoring of treatment response in advanced colorectal cancer by Zou, Donghui, Day, Robert, Cocadiz, Judy A, Parackal, Sarah, Mitchell, Wilson, Black, Michael A, Lawrence, Ben, Fitzgerald, Sandra, Print, Cristin, Jackson, Christopher, Guilford, Parry

“…Abstract Accurate assessment of chemotherapy response provides the means to terminate ineffective treatment, trial alternative drug regimens or schedules and…”
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MODL-21. INTEGRATIVE APPROACHES IN FUNCTIONAL GENOMICS TO IDENTIFY GENETIC DEPENDENCIES IN PEDIATRIC BRAIN CANCER by Sun, Claire, Drinkwater, Caroline, Sooraj, Dhanya, Bradshaw, Gabrielle, Shi, Claire, Fernando, Dasun, Parackal, Sarah, Gough, Daniel, Cain, Jason, Firestein, Ron

“…Abstract The precise decoding of human genomes facilitated by the advancements in next-generation sequencing has led to a better understanding of genetic…”
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Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities by Sun, Claire Xin, Daniel, Paul, Bradshaw, Gabrielle, Shi, Hui, Loi, Melissa, Chew, Nicole, Parackal, Sarah, Tsui, Vanessa, Liang, Yuqing, Koptyra, Mateusz, Adjumain, Shazia, Sun, Christie, Chong, Wai Chin, Fernando, Dasun, Drinkwater, Caroline, Tourchi, Motahhareh, Habarakada, Dilru, Sooraj, Dhanya, Carvalho, Diana, Storm, Phillip B., Baubet, Valerie, Sayles, Leanne C., Fernandez, Elisabet, Nguyen, Thy, Pörksen, Mia, Doan, Anh, Crombie, Duncan E., Panday, Monty, Zhukova, Nataliya, Dun, Matthew D., Ludlow, Louise E., Day, Bryan, Stringer, Brett W., Neeman, Naama, Rubens, Jeffrey A., Raabe, Eric H., Vinci, Maria, Tyrrell, Vanessa, Fletcher, Jamie I., Ekert, Paul G., Dumevska, Biljana, Ziegler, David S., Tsoli, Maria, Syed Sulaiman, Nur Farhana, Loh, Amos Hong Pheng, Low, Sharon Yin Yee, Sweet-Cordero, E. Alejandro, Monje, Michelle, Resnick, Adam, Jones, Chris, Downie, Peter, Williams, Bryan, Rosenbluh, Joseph, Gough, Daniel, Cain, Jason E., Firestein, Ron

“…Pediatric solid and central nervous system tumors are the leading cause of cancer-related death among children. Identifying new targeted therapies necessitates…”
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BIOL-01. GENERATION AND MULTI-OMICS CHARACTERIZATION OF 203 PEDIATRIC CNS TUMOUR MODELS REVEALS NEW THERAPEUTIC VULNERABILITIES by Sun, Claire, Daniel, Paul, Chew, Nicole, Shi, Hui, Loi, Melissa, Parackal, Sarah, Koptyra, Mateusz, Adjumain, Shazia, Panday, Monty, Habarakada, Dilru, Tourchi, Motahhareh, Neeman, Naama, Resnick, Adam, Jones, Chris, Cain, Jason, Firestein, Ron

“…Abstract Pediatric Central Nervous System (CNS) tumors are the leading cause of cancer-related death among children. Identifying new targeted therapies…”
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DIPG-18. IDENTIFICATION OF TARGETABLE PATHWAY DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA by Parackal, Sarah, Chong, Wai Chin, Bradshaw, Gabrielle, Sun, Claire, Daniel, Paul, Roussel, Enola, Jayasekara, Samantha, Crombie, Duncan, Firestein, Ron, Cain, Jason

“…Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive paediatric brainstem tumour with a dismal prognosis. Recurrent heterozygous mutations…”
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EXTH-36. COMBINING ONC201 AND PAXALISIB FOR THE TREATMENT OF DIFFUSE MIDLINE GLIOMA (DMG); THE PRECLINICAL RESULTS UNDERPINNING THE INTERNATIONAL PHASE II CLINICAL TRIAL (NCT05009992) by Jackson, Evangeline, Duchatel, Ryan, Staudt, Dilana, Persson, Mika, Mannan, Abdul, Yadavilli, Sridevi, Parackal, Sarah, Game, Shaye, Chong, Wai Chin, Jayasekara, W Samantha, Grand, Marion Le, Kearney, Padraic, Douglas, Alicia, Findlay, Izac, Germon, Zacary, McEwen, Holly, Beitaki, Tyrone, Patabendige, Adjanie, Skerrett-byrne, David, Nixon, Brett, Smith, Nathan, Day, Bryan, Manoharan, Neevika, Nagabushan, Sumanth, Hansford, Jordan, Govender, Dinisher, McCowage, Geoffrey, Firestein, Ron, Howlett, Meegan, Endersby, Raelene, Gottardo, Nicholas, Alvaro, Frank, Waszak, Sebastian, Larsen, Martin, Sanguino, Yolanda Colino, Valdes-Mora, Fatima, Rakotomalala, Andria, Meignan, Samuel, Pasquier, Eddy, Andre, Nicolas, Hulleman, Esther, Eisenstat, David, Vitanza, Nicholas, Nazarian, Javad, Koschmann, Carl, Mueller, Sabine, Cain, Jason, Dun, Matthew

“…Abstract Diffuse midline gliomas (DMGs) diagnosed in the pons (DIPG) are universally fatal central nervous system tumors and are the leading cause of…”
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EXTH-31. EXPLOITING THE GENETIC DEPENDENCY ON PI3K/MTOR SIGNALING FOR THE TREATMENT OF H3-ALTERED DIFFUSE MIDLINE GLIOMA by Duchatel, Ryan, Jackson, Evangeline, Parackal, Sarah, Sun, Claire, Daniel, Paul, Mannan, Abdul, Findlay, Izac, Staudt, Dilana, Germon, Zacary, Laternser, Sandra, Kiltschewskij, Dylan, Kearney, Padraic, Jamaluddin, M Fairuz B, Douglas, Alicia, Beitaki, Tyrone, Perrson, Mika, Thomas, Bryce, Manning, Elizabeth, Murray, Heather, Verrills, Nikki, Vilain, Ricardo, Skerrett-byrne, David, Nixon, Brett, Hua, Susan, DeBock, Charles, Valdes-Mora, Fatima, Tsoli, Maria, Ziegler, David, Cairns, Murray, Raabe, Eric, Vitanza, Nicholas, Phoenix, Timothy, Koschmann, Carl, Alvaro, Frank, Dayas, Christopher, Tinkle, Christopher, Eisenstat, David, Firestein, Ron, Mueller, Sabine, Nazarian, Javad, Cain, Jason, Dun, Matthew

“…Abstract Recurring activating mutations, amplifications and allelic loss of the negative repressors of the phosphatidylinositol-4,5-bisphosphate 3-kinase…”
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EXTH-12. PRECLINICAL AND CASE STUDY EXAMINATION OF THE COMBINATION OF THE CLPP AGONIST ONC201 WITH THE PI3K/AKT INHIBITOR PAXALISIB FOR THE TREATMENT OF DIFFUSE MIDLINE GLIOMA by Jackson, Evangeline, Duchatel, Ryan, Persson, Mika, Mannan, Abdul, Yadavilli, Sridevi, Parackal, Sarah, Game, Shaye, Chong, Wai Chin, Jayasekara, Samantha, Le Grand, Marion, Kearney, Padraic, Douglas, Alicia, Findlay, Izac, Staudt, Dilana, Germon, Zacary, Skerrett-Byrne, David, Nixon, Brett, Smith, Nathan, Hulleman, Esther, Day, Bryan, McCowage, Geoffrey, Alvaro, Frank, Waszak, Sebastian, Larsen, Martin, Colino-Sanguino, Yolanda, Valdes-Mora, Fatima, Rakotomalala, Andria, Meignan, Samuel, Pasquier, Eddy, Vitanza, Nicholas, Nazarian, Javad, Koschmann, Carl, Cain, Jason, Mueller, Sabine, Dun, Matthew

“…Abstract Diffuse midline gliomas (DMGs), including those of the pons (diffuse intrinsic pontine glioma - DIPG), are pediatric CNS tumors recognized as the most…”
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MODL-17. The Childhood Brain Cancer Cell Line Atlas: A Resource for Biomarker Identification and Therapeutic Development by Daniel, Paul, Sun, Claire, Koptyra, Mateusz, Drinkwater, Caroline, Chew, Nicole, Bradshaw, Gabrielle, Loi, Melissa, Shi, Claire, Tourchi, Motahhareh, Parackal, Sarah, Chong, Wai Chin, Fernando, Dasun, Adjumain, Shazia, Nguyen, Hoang, Habarakada, Dilru, Sooraj, Dhanya, Crombie, Duncan, Zhukova, Nataliya, Jones, Chris, Rubens, Jeffrey, Raabe, Eric, Vinci, Maria, Dun, Matt, Ludlow, Louise, Nazarian, Javad, Fletcher, Jamie, Ekert, Paul, Ziegler, David, Loh, Amos Hong Pheng, Low, Sharon Yin Yee, Monje, Michelle, Neeman, Naama, Williams, Bryan, Resnick, Adam, Gough, Daniel, Cain, Jason, Firestein, Ron

“…Abstract Cell lines represent the most versatile and widely used models of cancer and, as such, are critical for identifying and advancing new therapies…”
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DIPG-07. Preclinical and case study results underpinning the phase II clinical trial testing the combination of ONC201 and paxalisib for the treatment of patients with diffuse midline glioma (NCT05009992) by Dun, Matthew D, Jackson, Evangeline R, Duchatel, Ryan J, Persson, Mika L, Mannan, Abdul, Yadavilli, Sridevi, Parackal, Sarah, Game, Shaye, Chong, Wai Chin, Jayasekara, Samantha, Le Grand, Marion, Kearney, Padraic S, Douglas, Alicia M, Findlay, Izac J, Staudt, Dilana, Germon, Zacary P, Skerrett-Byrne, David A, Nixon, Brett, Smith, Nathan D, Hulleman, Esther, Day, Bryan, McCowage, Geoff B, Alvaro, Frank, Waszak, Sebastian M, Larsen, Martin R, Colino-Sanguino, Yolanda, Valdes-Mora, Fatima, Rakotomalala, Andria, Meignan, Samuel, Pasquier, Eddy, Vitanza, Nicholas A, Nazarian, Javad, Koschmann, Carl, Cain, Jason, Mueller, Sabine

“…Abstract Diffuse midline gliomas (DMG), including those of the brainstem (diffuse intrinsic pontine glioma - DIPG), are pediatric CNS tumors recognized as the…”
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Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy by Chong, Wai C., Jayasekara, W. Samantha N., Vaghjiani, Vijesh G., Parackal, Sarah, Sun, Claire, Popovski, Dean, Algar, Elizabeth M., Firestein, Ron, Wood, Paul J., Khan, Sara, Huang, Annie, Ashley, David M., Downie, Peter, Cain, Jason E.

“…Atypical teratoid rhabdoid tumour (ATRT) is a rare but highly aggressive undifferentiated solid tumour arising in the central nervous system and predominantly…”
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SYST-15 GENERATION AND MULTI-DIMENSIONAL PROFILING OF A CHILDHOOD CANCER CELL LINE ATLAS DEFINES NEW THERAPEUTIC OPPORTUNITIES by Daniel, Paul, Sun, Claire Xin, Bradshaw, Gabrielle, Shi, Hui, Loi, Melissa, Chew, Nicole, Parackal, Sarah, Tsui, Vanessa, Liang, Yuqing, Koptyra, Mateusz, Adjumain, Shazia, Sun, Christie, Chong, Wai Chin, Fernando, Dasun, Drinkwater, Caroline, Tourchi, Motahhareh, Habarakada, Dilru, Carvalho, Diana, Storm, Phillip B, Baubet, Valerie, Sayles, Leanne C, Fernandez, Elisabet, Zhukova, Nataliya, Dun, Matthew D, Ludlow, Louise E, Day, Bryan, Stringer, Brett W, Neeman, Naama, Rubens, Jeffrey A, Raabe, Eric H, Vinci, Maria, Tyrrell, Vanessa, Fletcher, Jamie I, Ekert, Paul G, Dumevska, Biljana, Ziegler, David S, Tsoli, Maria, Sulaiman, Nur Farhana Syed, Loh, Amos Hong Pheng, Low, Sharon Yin Yee, Sweet-Cordero, E Alejandro, Monje, Michelle, Resnick, Adam, Jones, Chris, Downie, Peter, Williams, Bryan, Rosenbluh, Joseph, Gough, Daniel, Cain, Jason E, Firestein, Ron

“…Abstract Paediatric solid tumours are the leading cause of cancer related death amongst children. Identification of paediatric-specific targeted therapies…”
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ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma by Jackson, Evangeline R, Duchatel, Ryan J, Staudt, Dilana E, Persson, Mika L, Mannan, Abdul, Yadavilli, Sridevi, Parackal, Sarah, Game, Shaye, Chong, Wai Chin, Jayasekara, W Samantha N, Grand, Marion Le, Kearney, Padraic S, Douglas, Alicia M, Findlay, Izac J, Germon, Zacary P, McEwen, Holly P, Beitaki, Tyrone S, Patabendige, Adjanie, Skerrett-Byrne, David A, Nixon, Brett, Smith, Nathan D, Day, Bryan, Manoharan, Neevika, Nagabushan, Sumanth, Hansford, Jordan R, Govender, Dinisha, McCowage, Geoff B, Firestein, Ron, Howlett, Meegan, Endersby, Raelene, Gottardo, Nicholas G, Alvaro, Frank, Waszak, Sebastian M, Larsen, Martin R, Colino-Sanguino, Yolanda, Valdes-Mora, Fatima, Rakotomalala, Andria, Meignan, Samuel, Pasquier, Eddy, André, Nicolas, Hulleman, Esther, Eisenstat, David D, Vitanza, Nicholas A, Nazarian, Javad, Koschmann, Carl, Mueller, Sabine, Cain, Jason E, Dun, Matthew D

“…Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the most lethal of childhood cancers. Palliative radiotherapy is the…”
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