Search Results - "Paquet, Charlotte"

Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist by Simonneau, Claire, Bérénice Leclercq, Mougel, Alexandra, Adriaenssens, Eric, Paquet, Charlotte, Raibaut, Laurent, Ollivier, Nathalie, Drobecq, Hervé, Marcoux, Julien, Cianférani, Sarah, Tulasne, David, de Jonge, Hugo, Melnyk, Oleg, Vicogne, Jérôme

“…The development of MET receptor agonists is an important goal in regenerative medicine, but is limited by the complexity and incomplete understanding of its…”
Get full text

Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development by Wouters, Kristiaan, Cudejko, Céline, Gijbels, Marion J J, Fuentes, Lucia, Bantubungi, Kadiombo, Vanhoutte, Jonathan, Dièvart, Rebecca, Paquet, Charlotte, Bouchaert, Emmanuel, Hannou, Sarah Anissa, Gizard, Florence, Tailleux, Anne, de Winther, Menno P J, Staels, Bart, Paumelle, Réjane

“…A genomic region near the CDKN2A locus, encoding p16(INK4a), has been associated to type 2 diabetes and atherosclerotic vascular disease, conditions in which…”
Get full text

p16INK4a deficiency promotes IL-4–induced polarization and inhibits proinflammatory signaling in macrophages by Cudejko, Céline, Wouters, Kristiaan, Fuentes, Lucía, Hannou, Sarah Anissa, Paquet, Charlotte, Bantubungi, Kadiombo, Bouchaert, Emmanuel, Vanhoutte, Jonathan, Fleury, Sébastien, Remy, Patrick, Tailleux, Anne, Chinetti-Gbaguidi, Giulia, Dombrowicz, David, Staels, Bart, Paumelle, Réjane

“…The CDKN2A locus, which contains the tumor suppressor gene p16INK4a, is associated with an increased risk of age-related inflammatory diseases, such as…”
Get full text

The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis by Hennuyer, Nathalie, Duplan, Isabelle, Paquet, Charlotte, Vanhoutte, Jonathan, Woitrain, Eloise, Touche, Véronique, Colin, Sophie, Vallez, Emmanuelle, Lestavel, Sophie, Lefebvre, Philippe, Staels, Bart

“…Abstract Background Atherosclerosis is characterized by lipid accumulation and chronic inflammation in the arterial wall. Elevated levels of apolipoprotein…”
Get full text

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy by Woldt, Estelle, Sebti, Yasmine, Solt, Laura A, Duhem, Christian, Lancel, Steve, Eeckhoute, Jérôme, Hesselink, Matthijs K C, Paquet, Charlotte, Delhaye, Stéphane, Shin, Youseung, Kamenecka, Theodore M, Schaart, Gert, Lefebvre, Philippe, Nevière, Rémi, Burris, Thomas P, Schrauwen, Patrick, Staels, Bart, Duez, Hélène

“…Bart Staels and his colleagues show that the transcription factor Rev-erb-α is highly expressed in oxidative muscle and, via loss- and gain-of-function…”
Get full text

Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors by Mekki, Meriem Sarah, Mougel, Alexandra, Vinchent, Audrey, Paquet, Charlotte, Copin, Marie-Christine, Leroy, Catherine, Kherrouche, Zoulika, Bonte, Jean-Paul, Melnyk, Oleg, Vicogne, Jérôme, Tulasne, David

“…The receptor tyrosine kinase MET and its ligand, the Hepatocyte Growth Factor/Scattor Factor (HGF/SF), are essential to the migration, morphogenesis, and…”
Get full text

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice by Deprez-Poulain, Rebecca, Hennuyer, Nathalie, Bosc, Damien, Liang, Wenguang G., Enée, Emmanuelle, Marechal, Xavier, Charton, Julie, Totobenazara, Jane, Berte, Gonzague, Jahklal, Jouda, Verdelet, Tristan, Dumont, Julie, Dassonneville, Sandrine, Woitrain, Eloise, Gauriot, Marion, Paquet, Charlotte, Duplan, Isabelle, Hermant, Paul, Cantrelle, François- Xavier, Sevin, Emmanuel, Culot, Maxime, Landry, Valerie, Herledan, Adrien, Piveteau, Catherine, Lippens, Guy, Leroux, Florence, Tang, Wei-Jen, van Endert, Peter, Staels, Bart, Deprez, Benoit

Get full text

Abstract 19434: The Novel PPARalpha-Selective Agonist K-877 Improves Dyslipidemia, Enhances Reverse Cholesterol Transport and Decreases Inflammation and Atherosclerosis by Hennuyer, Nathalie, Duplan, Isabelle, Paquet, Charlotte, Vanhoutte, Jonathan, Touche, Véronique, Chinetti, Giulia, Lestavel, Sophie, Takizawa, Toshiaki, Yamazaki, Yukiyoshi, Tanabe, Sohei, Staels, Bart

“…Abstract only Background: Atherosclerosis is characterized by lipid accumulation and chronic inflammation in the arterial wall. Elevated levels of…”
Get full text

Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonistElectronic supplementary information (ESI) available: Descriptions of reagents, antibodies, immunoblotting, MTT assay, scattering assay, morphogenesis assay and statistical analysis. See DOI: 10.1039/c4sc03856h by Simonneau, Claire, Bérénice Leclercq, Mougel, Alexandra, Adriaenssens, Eric, Paquet, Charlotte, Raibaut, Laurent, Ollivier, Nathalie, Drobecq, Hervé, Marcoux, Julien, Cianférani, Sarah, Tulasne, David, de Jonge, Hugo, Melnyk, Oleg, Vicogne, Jérôme

“…The development of MET receptor agonists is an important goal in regenerative medicine, but is limited by the complexity and incomplete understanding of its…”
Get full text

Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist† †Electronic supplementary information (ESI) available: Descriptions of reagents, antibodies, immunoblotting, MTT assay, scattering assay, morphogenesis assay and statistical analysis. See DOI: 10.1039/c4sc03856h Click here for additional data file by Simonneau, Claire, Bérénice Leclercq, Mougel, Alexandra, Adriaenssens, Eric, Paquet, Charlotte, Raibaut, Laurent, Ollivier, Nathalie, Drobecq, Hervé, Marcoux, Julien, Cianférani, Sarah, Tulasne, David, de Jonge, Hugo, Melnyk, Oleg, Vicogne, Jérôme

“…Clustering of synthetic biotinylated K1 domain from HGF/SF by streptavidin is sufficient to generate a potent MET agonist. The development of MET receptor…”
Get full text

Rev-erb-[alpha] modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy by Woldt, Estelle, Sebti, Yasmine, Solt, Laura A, Duhem, Christian, Lancel, Steve, Eeckhoute, Jérôme, Hesselink, Matthijs K C, Paquet, Charlotte, Delhaye, Stéphane, Shin, Youseung, Kamenecka, Theodore M, Schaart, Gert, Lefebvre, Philippe, Nevière, Rémi, Burris, Thomas P, Schrauwen, Patrick, Staels, Bart, Duez, Hélène

“…The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and the inflammatory response in macrophages. We show here that…”
Get full text

Bone Marrow p16.sup.INK4a-Deficiency Does Not Modulate Obesity, Glucose Homeostasis or Atherosclerosis Development by Wouters, Kristiaan, Cudejko, Céline, Gijbels, Marion J. J, Fuentes, Lucia, Bantubungi, Kadiombo, Vanhoutte, Jonathan, Dièvart, Rebecca, Paquet, Charlotte, Bouchaert, Emmanuel, Hannou, Sarah Anissa, Gizard, Florence, Tailleux, Anne, de Winther, Menno P. J, Staels, Bart, Paumelle, Réjane

“…Objective A genomic region near the CDKN2A locus, encoding p16.sup.INK4a, has been associated to type 2 diabetes and atherosclerotic vascular disease,…”
Get full text

p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages: p16INK4a function in macrophages by Cudejko, Céline, Wouters, Kristiaan, Fuentes, Lucía, Hannou, Sarah Anissa, Paquet, Charlotte, Bantubungi, Kadiombo, Bouchaert, Emmanuel, Vanhoutte, Jonathan, Fleury, Sébastien, Remy, Patrick, Tailleux, Anne, Chinetti, Giulia, Dombrowicz, David, Staels, Bart, Paumelle, Réjane

“…The CDKN2A locus, which contains the tumor suppressor gene p16(INK4a), is associated with an increased risk of age-related inflammatory diseases, such as…”
Get full text