Search Results - "Papworth, D."

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells by Morelli, Adrian E., Larregina, Adriana T., Shufesky, William J., Sullivan, Mara L.G., Stolz, Donna Beer, Papworth, Glenn D., Zahorchak, Alan F., Logar, Alison J., Wang, Zhiliang, Watkins, Simon C., Falo, Louis D., Thomson, Angus W.

“…Exosomes are nanovesicles released by leukocytes and epithelial cells. Although their function remains enigmatic, exosomes are a source of antigen and transfer…”
Get full text

Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production by Morelli, Adrian E., Larregina, Adriana T., Shufesky, William J., Zahorchak, Alan F., Logar, Alison J., Papworth, Glenn D., Wang, Zhiliang, Watkins, Simon C., Falo, Louis D., Thomson, Angus W.

“…Under steady-state conditions, internalization of self-antigens embodied in apoptotic cells by dendritic cells (DCs) resident in peripheral tissue followed by…”
Get full text

Aspirin Inhibits In Vitro Maturation and In Vivo Immunostimulatory Function of Murine Myeloid Dendritic Cells by Hackstein, Holger, Morelli, Adrian E, Larregina, Adriana T, Ganster, Raymond W, Papworth, Glenn D, Logar, Alison J, Watkins, Simon C, Falo, Louis D, Thomson, Angus W

“…Aspirin is the most commonly used analgesic and antiinflammatory agent. In this study, at physiological concentrations, it profoundly inhibited CD40, CD80,…”
Get full text

Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors by Sato, Hidemitsu, Kuwashima, Naruo, Sakaida, Tsukasa, Hatano, Manabu, Dusak, Jill E, Fellows-Mayle, Wendy K, Papworth, Glenn D, Watkins, Simon C, Gambotto, Andrea, Pollack, Ian F, Okada, Hideho

“…We have created a novel cellular vehicle for gene therapy of malignant gliomas by transfection of murine bone marrow stroma cells (MSCs) with a cDNA encoding…”
Get full text

Chromosomal Instability in the Descendants of Unirradiated Surviving Cells after α -Particle Irradiation by Lorimore, S. A., Kadhim, M. A., Pocock, D. A., Papworth, D., Stevens, D. L., Goodhead, D. T., Wright, E. G.

“…We have demonstrated chromosomal instability in the clonal descendants of hemopoietic stem cells after irradiating murine bone marrow with α -particles…”
Get full text

Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes by BERTERA, Suzanne, CRAWFORD, Megan L, ALEXANDER, Angela M, PAPWORTH, Glenn D, WATKINS, Simon C, ROBBINS, Paul D, TRUCCO, Massimo

“…Gene Transfer of Manganese Superoxide Dismutase Extends Islet Graft Function in a Mouse Model of Autoimmune Diabetes Suzanne Bertera 1 , Megan L. Crawford 1 ,…”
Get full text

In vivo chromosomal instability and transmissible aberrations in the progeny of haemopoietic stem cells induced by high- and low-LET radiations by Watson, G. E., Pocock, D. A., Papworth, D., Lorimore, S. A., Wright, E. G.

“…Purpose : To study stable and unstable chromosomal aberrations in the haemopoietic cells of CBA/H mice after exposure to both high- and low-LET radiations…”
Get full text

Dependence of the Yield of DNA Double-Strand Breaks in Chinese Hamster V79-4 Cells on the Photon Energy of Ultrasoft X Rays by de Lara, C. M., Hill, M. A., Jenner, T. J., Papworth, D., O'Neill, P.

“…de Lara, C. M., Hill, M. A., Jenner, T. J., Papworth, D. and O'Neill, P. Dependence of the Yield of DNA Double-Strand Breaks in Chinese Hamster V79-4 Cells on…”
Get full text

Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis by Feili-Hariri, Maryam, Falkner, Dewayne H, Gambotto, Andrea, Papworth, Glenn D, Watkins, Simon C, Robbins, Paul D, Morel, Penelope A

“…Our previous studies demonstrated that adoptive transfer of dendritic cells (DC) prevents diabetes in young nonobese diabetic (NOD) mice by inducing regulatory…”
Get more information

Trafficking of the Ca2+-activated K+Channel, hIK1, Is Dependent upon a C-terminal Leucine Zipper by Syme, Colin A, Hamilton, Kirk L, Jones, Heather M, Gerlach, Aaron C, Giltinan, LeeAnn, Papworth, Glenn D, Watkins, Simon C, Bradbury, Neil A, Devor, Daniel C

“…We demonstrate that the C-terminal truncation of hIK1 results in a loss of functional channels. This could be caused by either (i) a failure of the channel to…”
Get full text

Role of the NH2 Terminus in the Assembly and Trafficking of the Intermediate Conductance Ca2+-activated K+ Channel hIK1 by Jones, Heather M., Hamilton, Kirk L., Papworth, Glenn D., Syme, Colin A., Watkins, Simon C., Bradbury, Neil A., Devor, Daniel C.

“…The role of the NH2-terminal leucine zipper and dileucine motifs of hIK1 in the assembly, trafficking, and function of the channel was investigated using cell…”
Get full text

Sequential delivery of interferon-α gene and DCs to intracranial gliomas promotes an effective antitumor response by TSUGAWA, T, KUWASHIMA, N, POLLACK, I. F, OKADA, H, SATO, H, FELLOWS-MAYLE, W. K, DUSAK, J. E, OKADA, K, PAPWORTH, G. D, WATKINS, S. C, GAMBOTTO, A, YOSHIDA, J

“…Effective presentation of tumor antigens by dendritic cells (DCs) is considered to be essential for the induction of antitumor T-cell responses. Apoptotic and…”
Get full text

Vascularization and tissue infiltration of a biodegradable polyurethane matrix by Ganta, Sudhakar R., Piesco, Nicholas P., Long, Ping, Gassner, Robert, Motta, Luis F., Papworth, Glenn D., Stolz, Donna B., Watkins, Simon C., Agarwal, Sudha

“…Urethanes are frequently used in biomedical applications because of their excellent biocompatibility. However, their use has been limited to bioresistant…”
Get full text

Susceptibility to radiation-induced leukaemia/lymphoma is genetically separable from sensitivity to radiation-induced genomic instability by Boulton, H. Cleary, D. Papworth, M. Plumb, E.

“…Purpose : To determine whether there is a relationship between the genetics underlying the susceptibility to radiation-induced leukaemia in CBA/H (acute…”
Get full text

Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition by Montecalvo, Angela, Shufesky, William J, Beer Stolz, Donna, Sullivan, Mara G, Wang, Zhiliang, Divito, Sherrie J, Papworth, Glenn D, Watkins, Simon C, Robbins, Paul D, Larregina, Adriana T, Morelli, Adrian E

“…Exosomes are nanovesicles released by different cell types including dendritic cells (DCs). The fact that exosomes express surface MHC-peptide complexes…”
Get full text

Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways by Kuwashima, Naruo, Nishimura, Fumihiko, Eguchi, Junichi, Sato, Hidemitsu, Hatano, Manabu, Tsugawa, Takahiko, Sakaida, Tsukasa, Dusak, Jill E, Fellows-Mayle, Wendy K, Papworth, Glenn D, Watkins, Simon C, Gambotto, Andrea, Pollack, Ian F, Storkus, Walter J, Okada, Hideho

“…We tested whether modulation of the CNS-tumor microenvironment by delivery of IFN-alpha-transduced dendritic cells (DCs: DC-IFN-alpha) would enhance the…”
Get full text

Chromosome breakpoint distribution of damage induced in peripheral blood lymphocytes by densely ionizing radiation by Anderson, R. M., Sumption, N. D., Papworth, D. G., Goodhead, D. T.

“…Purpose: To assess the chromosomal breakpoint distribution in human peripheral blood lymphocytes (PBL) after exposure to a low dose of high linear energy…”
Get full text

Increased complexity of radiation-induced chromosome aberrations consistent with a mechanism of sequential formation by Anderson, R M, Papworth, D G, Stevens, D L, Sumption, N D, Goodhead, D T

“…Complex chromosome aberrations (any exchange involving three or more breaks in two or more chromosomes) are effectively induced in peripheral blood lymphocytes…”
Get more information

Carcinogenicity of radon radon decay product inhalation in rats - effect of dose, dose rate and unattached fraction by Collier, C. G., Strong, J. C., Humphreys, J. A., Timpson, N., Baker, S. T., Eldred, T., Cobb, L., Papworth, D., Haylock, R.

“…Purpose: The effects of inhalation of radon radon decay products at different total doses, dose rates and 'unattached' fractions were investigated in a life…”
Get full text

Dose- and time-response relationships for lethal mutations and chromosomal instability induced by ionizing radiation in an immortalized human keratinocyte cell line by Mothersill, M. A. Kadhim, S. O'Reilly, D. Papworth, S. J. Marsden, C. B. Seymour, E. G. Wright, C.

“…Purpose : To investigate the relationship between two well-established delayed effects of ionizing radiation, experiments were conducted to determine the…”
Get full text