Search Results - "Papst, Philip J."
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Canonical Transient Receptor Potential Channels Promote Cardiomyocyte Hypertrophy through Activation of Calcineurin Signaling
Published in The Journal of biological chemistry (03-11-2006)“…The calcium/calmodulin-dependent phosphatase calcineurin plays a central role in the control of cardiomyocyte hypertrophy in response to pathological stimuli…”
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Regulation of Cardiac Stress Signaling by Protein Kinase D1
Published in Molecular and Cellular Biology (01-05-2006)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5
Published in Molecular and Cellular Biology (01-10-2004)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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MEKK1 Suppresses Oxidative Stress-Induced Apoptosis of Embryonic Stem Cell-Derived Cardiac Myocytes
Published in Proceedings of the National Academy of Sciences - PNAS (21-12-1999)“…A combination of in vitro embryonic stem (ES) cell differentiation and targeted gene disruption has defined complex regulatory events underlying oxidative…”
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Role of Phasic Dynamism of p38 Mitogen-Activated Protein Kinase Activation in Ischemic Preconditioning of the Canine Heart
Published in Circulation research (02-02-2001)“…ABSTRACT —Although ischemic stress, including ischemic preconditioning (IP), activates p38 mitogen-activated protein kinase (MAPK), the relationship between…”
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Role of MEKK2-MEK5 in the Regulation of TNF-α Gene Expression and MEKK2-MKK7 in the Activation of c-Jun N-terminal Kinase in Mast Cells
Published in Proceedings of the National Academy of Sciences - PNAS (10-04-2001)“…Cross-linking of the high-affinity IgE receptor (FcεRI) on mast cells with IgE and multivalent antigen triggers mitogen-activated protein (MAP) kinase…”
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Hepatic maturation in differentiating embryonic stem cells in vitro
Published in FEBS letters (18-05-2001)“…We investigated the potential of mouse embryonic stem (ES) cells to differentiate into hepatocytes in vitro. Differentiating ES cells expressed…”
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A high-performance liquid chromatography assay for quantification of cardiac myosin heavy chain isoform protein expression
Published in Analytical biochemistry (2011)“…Stress signaling in the myocardium results in enhanced expression of fetal β-myosin heavy chain (β-MyHC) and reduced expression of adult α-myosin heavy chain…”
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Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1
Published in Biochimica et biophysica acta (01-05-2009)“…Histone deacetylase 5 (HDAC5) represses expression of nuclear genes that promote cardiac hypertrophy. Agonism of a variety of G protein coupled receptors…”
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Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors : The role of protein kinase A and p38 mitogen-activated protein kinase
Published in Circulation (New York, N.Y.) (07-08-2001)“…Phosphodiesterase III inhibitors (PDEIII-Is) improve the hemodynamic status of heart failure via inotropic/vasodilatory effects attributable to the increase in…”
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MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
Published in The EMBO journal (16-10-2000)“…Ligation of the high‐affinity IgE receptor (FcϵRI) or of c‐Kit stimulates cytokine production in mast cells. We show that MEK kinase 2 (MEKK2), a MAPK kinase…”
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Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats
Published in Cardiovascular drugs and therapy (01-10-2000)“…Chronic inhibition of nitric oxide (NO) synthesis is reported to induce the thickening of coronary artery walls and cardiac hypertrophy in vivo via angiotensin…”
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Amino Acid-dependent Control of p70s6k
Published in The Journal of biological chemistry (08-01-1999)“…In human T-lymphoblastoid cells, downstream signaling events of mammalian target of rapamycin (mTOR), including the activity of p70s6k and phosphorylation of…”
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Cdc2-Cyclin B Phosphorylates p70 S6 Kinase on Ser411at Mitosis
Published in The Journal of biological chemistry (12-06-1998)“…The carboxyl terminus of p70 S6 kinase (p70s6k) has a set of Ser and Thr residues (Ser411, Ser418, Ser424, and Thr421) phosphorylated in vivo by an…”
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Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation
Published in The Journal of biological chemistry (08-01-1999)“…In human T-lymphoblastoid cells, downstream signaling events of mammalian target of rapamycin (mTOR), including the activity of p70(s6k) and phosphorylation of…”
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l-Asparaginase Inhibits the Rapamycin-Targeted Signaling Pathway
Published in Biochemical and biophysical research communications (05-07-1999)“…l-Asparaginase is widely used in the treatment of acute lymphoblastic leukemia. l-Asparaginase preparation derived from E. coli converts asparagine (Asn) and…”
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Chronic treatment with FK506 increases p70 S6 kinase activity associated with reduced nitric oxide synthase activity in rabbit hearts
Published in Cardiovascular drugs and therapy (01-06-2000)“…FK506, an immunosuppressant, modulates phosphorylation of nitric oxide (NO) synthase, and induces cardiac hypertrophy in clinical settings. Having recently…”
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