Search Results - "Pappu, A. S"

Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome by Hager, E. J, Tse, H. M, Piganelli, J. D, Gupta, M, Baetscher, M, Tse, T. E, Pappu, A. S, Steiner, R. D, Hoffmann, G. F, Gibson, K. M

“…In the current study our objective was to develop a murine model of human hyper-IgD syndrome (HIDS) and severe mevalonic aciduria (MA), autoinflammatory…”
Get full text

Effects of colesevelam HCl on sterol and bile acid excretion in patients with type IIa hypercholesterolemia by DONOVAN, J. M, VON BERGMANN, K, SETCHELL, K. D. R, ISAACSOHN, J, PAPPU, A. S, ILLINGWORTH, D. R, OLSON, T, BURKE, S. K

“…Colesevelam HCl is a potent bile acid-binding polymer. This study's aim was to determine effects of colesevelam HCl on sterol and bile acid excretion in…”
Get full text

Expanded-dose simvastatin is effective in homozygous familial hypercholesterolaemia by Raal, Frederick J, Pilcher, Gillian J, Illingworth, D.Roger, Pappu, Anuradha S, Stein, Evan A, Laskarzewski, Peter, Mitchel, Yale B, Melino, Michael R

“…Patients with homozygous familial hypercholesterolaemia (HFH) have abnormalities in both low-density lipoprotein (LDL) receptor alleles, resulting in severe…”
Get full text

Dietary Cholesterol Feeding Suppresses Human Cholesterol Synthesis Measured by Deuterium Incorporation and Urinary Mevalonic Acid Levels by Jones, Peter J.H, Pappu, Anuradha S, Hatcher, Lauren, Li, Zi-Chi, Illingworth, D. Roger, Connor, William E

“…The objective of this study was to measure the response of cholesterol biosynthesis in subjects to three different amounts of dietary cholesterol50 (low), 350…”
Get full text

Correspondence between plasma mevalonic acid levels and deuterium uptake in measuring human cholesterol synthesis by Jones, P J, Pappu, A S, Illingworth, D R, Leitch, C A

“…To assess the validity of two techniques capable of identifying immediate changes in human cholesterol production, plasma mevalonic acid levels and the rate of…”
Get more information

Role of GH in regulating nocturnal rates of lipolysis and plasma mevalonate levels in normal and diabetic humans by Boyle, P J, Avogaro, A, Smith, L, Bier, D M, Pappu, A S, Illingworth, D R, Cryer, P E

“…To define the role that nocturnal increments in growth hormone (GH) play in maintaining lipolysis, glycerol turnover was measured in six patients with GH…”
Get full text

Mevalonate Availability and Cardiovascular Functions by Roullet, Jean-Baptiste, Xue, Hong, Pappu, Anuradha S., Roullet, Chantal, Holcomb, Scott, McCarron, David A.

“…Data delineating the relationship between disorders of cholesterol metabolism and elevated blood pressure (BP) do not exist. We postulated that mevalonate, the…”
Get full text

Diurnal variations in the plasma concentrations of mevalonic acid in patients with abetalipoproteinaemia by Pappu, A S, Illingworth, D R

“…Previous studies have demonstrated that changes in the rates of cholesterol biosynthesis can be evaluated by the determination of plasma concentrations of…”
Get more information

Premenopausal black women have more risk factors for coronary heart disease than white women by Gerhard, Glenn T, Sexton, Gary, Malinow, M.René, Wander, Rosemary C, Connor, Sonja L, Pappu, Anuradha S, Connor, William E

“…Premenopausal black women have a 2- to 3-fold greater rate of coronary heart disease (CHD) than premenopausal white women. The purpose of this study was to…”
Get full text

Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia by Pappu, A S, Illingworth, D R, Bacon, S

“…The effects of lovastatin, an inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMG CoA reductase), on 24-hour urinary excretion rates of…”
Get more information

Effect of nibbling versus gorging on cardiovascular risk factors: Serum uric acid and blood lipids by Jenkins, David J.A., Khan, Aneal, Jenkins, Alexandra L., Illingworth, Roger, Pappu, Anuradhe S., Wolever, Thomas M.S., Vuksan, Vladimir, Buckley, Gloria, Rao, A.Venketeshwer, Cunnane, Stephen C., Brighenti, Furio, Hawkins, Meredith, Abdolell, Mohamed, Corey, Paul, Patten, Robert, Josse, Robert G.

“…Nibbling has been reported to decrease serum cholesterol under fasting conditions, as well as the incidence of cardiovascular disease. It has been suggested…”
Get full text

Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function by Jenkins, David J.A., Kendall, Cyril W.C., Popovich, David G., Vidgen, Edward, Mehling, Christine C., Vuksan, Vladimir, Ransom, Thomas P.P., Rao, A.Venket, Rosenberg-Zand, Rachel, Tariq, Nauman, Corey, Paul, Jones, Peter J.H., Raeini, Mahmoud, Story, Jon A., Furumoto, Emily J., Illingworth, D.Roger, Pappu, Anuradha S., Connelly, Philip W.

“…We tested the effects of feeding a diet very high in fiber from fruit and vegetables. The levels fed were those, which had originally inspired the dietary…”
Get full text

Comparative hypolipidemic effects of lovastatin and simvastatin in patients with heterozygous familial hypercholesterolemia by Illingworth, D R, Bacon, S, Pappu, A S, Sexton, G J

“…We have compared the effects of lovastatin and simvastatin on plasma lipoproteins, fibrinogen and urinary mevalonic acid excretion in twenty-three patients…”
Get more information

Possible role of mevalonate in the hypercholesterolemia seen in experimental chronic renal failure by Subang, M C, Stewart-Phillips, J L, Pappu, A S, Subang, R, Gagnon, R F

“…Hypercholesterolemia may contribute to the pathogenesis of atherosclerosis associated with chronic renal failure (CRF). The mechanism underlying CRF-induced…”
Get more information

Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia by Raal, Frederick J., Pappu, Anuradha S., Illingworth, D.Roger, Pilcher, Gillian J., Marais, A.David, Firth, Jean C., Kotze, Maritha J., Heinonen, Therese M., Black, Donald M.

“…Patients with homozygous familial hypercholesterolaemia (HoFH) have markedly elevated low density lipoprotein (LDL) cholesterol levels that are refractory to…”
Get full text

Propranolol-induced inhibition of rat brain cytoplasmic phosphatidate phosphohydrolase by PAPPU, A. S, HAUSER, G

“…Propranolol, a cationic amphiphilic drug, caused enhanced incorporation of labeled precursor into phosphatidic acid and its metabolites in rat cerebral cortex…”
Get full text

Effects of Colesevelam HCl on Sterol and Bile Acid Excretion in Patients with Type IIa Hypercholesterolemia by Donovan, J. M., Von Bergmann, K., Setchell, K. D. R., Isaacsohn, J., Pappu, A. S., Illingworth, D. R., Olson, T., Burke, S. K.

“…Colesevelam HCl is a potent bile acid-binding polymer. This study's aim was to determine effects of colesevelam HCl on sterol and bile acid excretion in…”
Get full text

Increased urinary mevalonic acid excretion in patients with abetalipoproteinemia and homozygous hypobetalipoproteinemia by Illingworth, D R, Pappu, A S, Gregg, R E

“…Previous reports in which cholesterol homeostasis has been examined in patients with phenotypic abetalipoproteinemia have shown an increase in whole body…”
Get more information

Phospholipid metabolism changes in rat tissues in vitro after injections of propranolol by Pappu, A S, Hauser, G

“…When added to incubations in vitro. (+/-)-propranolol, a cationic amphiphilic drug, causes profound alterations in incorporation of [32P] orthosphosphate into…”
Get more information

Role of dietary cholesterol in the optimal diet for the treatment of hypercholesterolemia by Illingworth, D R, Hatcher, L F, Pappu, A S, Newcomb, K C, Connor, W E

“…This paper discusses studies in which the effects of dietary cholesterol on the plasma concentrations of lipids and lipoproteins have been evaluated in adult…”
Get more information