Search Results - "Pappolla, M. A."

Melatonin Treatment Enhances Aβ Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis by Pappolla, M A, Matsubara, E, Vidal, R, Pacheco-Quinto, J, Poeggeler, B, Zagorski, M, Sambamurti, K

“…It has been postulated that inadequate clearance of the amyloid β protein (Aβ) plays an important role in the accumulation of Aβ in sporadic late onset…”
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Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology by PAPPOLLA, M. A, BRYANT-THOMAS, WOLOZIN, B, SANO, M, CRUZ-SANCHEZ, F. F, THAL, L. J, PETANCESKA, S. S, REFOLO, L. M, HERBERT, D, PACHECO, J, GARCIA, M. Fabra, MANJON, M, GIRONES, X, HENRY, T. L, MATSUBARA, E, ZAMBON, D

“…Epidemiologic and experimental data suggest that cholesterol may play a role in the pathogenesis of AD. Modulation of cholesterolemia in transgenic animal…”
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An assessment of the antioxidant and the antiamyloidogenic properties of melatonin : implications for Alzheimer's disease by PAPPOLLA, M. A, CHYAN, Y.-J, POEGGELER, B, FRANGIONE, B, WILSON, G, GHISO, J, REITER, R. J

“…This review summarizes recent advancements in our understanding of the potential role of the amyloid beta protein in Alzheimer's disease. It also discusses the…”
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Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo by Pappolla, MA, Chyan, YJ, Omar, RA, Hsiao, K, Perry, G, Smith, MA, Bozner, P

“…Increased expression of antioxidant enzymes and heat-shock proteins are key markers of oxidative stress. Such proteins are abnormally present within the…”
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A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease by Refolo, L.M., Pappolla, M.A., LaFrancois, J., Malester, B., Schmidt, S.D., Thomas-Bryant, T., Tint, G.S., Wang, R., Mercken, M., Petanceska, S.S., Duff, K.E.

“…Clinical, epidemiological, and laboratory studies suggest that cholesterol may play a role in the pathogenesis of Alzheimer's disease (AD). Transgenic mice…”
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Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress by Smith, Mark A., Hirai, Keisuke, Hsiao, Karen, Pappolla, Miguel A., Harris, Peggy L. R., Siedlak, Sandra L., Tabaton, Massimo, Perry, George

“…: Increased awareness for a role of oxidative stress in the pathogenesis of Alzheimer's disease has highlighted the issue of whether oxidative damage is a…”
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Alzheimer β protein mediated oxidative damage of mitochondrial DNA: Prevention by melatonin by Pappolla, M. A., Chyan, Y.-J., Poeggeler, B., Bozner, P., Ghiso, J., LeDoux, S. P., Wilson, G. L.

“…: Most contemporary progress in Alzheimer's disease (AD) stems from the study of a 42–43 amino acid peptide, called the amyloid beta protein (Aβ), as the main…”
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Immunohistochemical evidence of antioxidant stress in Alzheimer's disease by PAPPOLLA, M. A, OMAR, R. A, KIM, K. S, ROBAKIS, N. K

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Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain by Poeggeler, Burkhard, Pappolla, Miguel A., Hardeland, Rüdiger, Rassoulpour, Arash, Hodgkins, Paul S., Guidetti, Paolo, Schwarcz, Robert

“…The hydroxyl radical scavenging activity of indole-3-propionate was evaluated by kinetic competition studies with the hydroxyl radical trapping reagent…”
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Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells by Sambamurti, K, Shioi, J, Anderson, J P, Pappolla, M A, Robakis, N K

“…The Alzheimer's amyloid precursor (APP) is cleaved by an unidentified enzyme (APP secretase) to produce soluble APP. Fractionation of PC12 cell homogenates in…”
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A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene by Matsubara, E., Tsuchiya, A., Minami, N., Nishino, I., Pappolla, M. A., Shoji, M., Abe, K.

“…A unique sib pair afflicted by limb girdle muscular dystrophy type 2A (LGMD2A) is described showing a slowly progressive autosomal recessive type of muscular…”
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Amyloid Deposition in Diffuse Plaques May Or May Not Start at the Neuronal Cell Surface Membrane by PAPPOLLA, M A

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The Amyloid β Protein Induces Oxidative Damage of Mitochondrial DNA by BOZNER, PETER, GRISHKO, VALENTINA, LEDOUX, SUSAN P, WILSON, GLENN L, CHYAN, Y-C, PAPPOLLA, MIGUEL A

“…Multiple lines of evidence suggest involvement of oxidative stress in the pathogenesis of Alzheimer disease (AD). The finding that amyloid beta peptide (Aβ)…”
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Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model by Refolo, Lorenzo M., Pappolla, Miguel A., Malester, Brian, LaFrancois, John, Bryant-Thomas, Tara, Wang, Rong, Tint, G.Stephen, Sambamurti, Kumar, Duff, Karen

“…Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's disease (AD). However, no direct evidence has been reported linking…”
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RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer's Disease by Nunomura, Akihiko, Perry, George, Pappolla, Miguel A, Wade, Ramon, Hirai, Keisuke, Chiba, Shigeru, Smith, Mark A

“…In this study we used an in situ approach to identify the oxidized nucleosides 8-hydroxydeoxyguanosine (8OHdG) and 8-hydroxyguanosine (8OHG), markers of…”
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Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome by NUNOMURA, AKIHIKO, PERRY, GEORGE, PAPPOLLA, MIGUEL A, FRIEDLAND, ROBERT P, HIRAI, KEISUKE, CHIBA, SHIGERU, SMITH, MARK A

“…The predictable chronological sequence of pathological events in Down syndrome (DS) provides the opportunity to rigorously investigate the relationship between…”
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Higher Incidence of Mild Cognitive Impairment in Familial Hypercholesterolemia by Zambón, Daniel, MD, PhD, Quintana, Melibea, MS, Mata, Pedro, MD, PhD, Alonso, Rodrigo, MD, PhD, Benavent, Jaume, MD, Cruz-Sánchez, Felix, MD, PhD, Gich, Jordi, MS, Pocoví, Miguel, MD, PhD, Civeira, Fernando, MD, PhD, Capurro, Sebastian, MD, Bachman, David, MD, Sambamurti, Kumar, PhD, Nicholas, Joyce, PhD, Pappolla, Miguel A., MD, PhD

“…Abstract Objective Hypercholesterolemia is an early risk factor for Alzheimer's disease. Low-density lipoprotein (LDL) receptors might be involved in this…”
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Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid by Chyan, Yau-Jan, Poeggeler, Burkhard, Omar, Rawhi A., Chain, Daniel G., Frangione, Blas, Ghiso, Jorge, Pappolla, Miguel A.

“…Widespread cerebral deposition of a 40–43-amino acid peptide called the amyloid β-protein (Aβ) in the form of amyloid fibrils is one of the most prominent…”
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Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization by Refolo, L M, Sambamurti, K, Efthimiopoulos, S, Pappolla, M A, Robakis, N K

“…Three different treatments (methylamine, colchicine, and 18 degrees C temperature block), known to disrupt normal endocytic internalization, significantly…”
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Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques by Pappolla, MA, Omar, RA, Vinters, HV

“…Amyloid is a component of the senile plaques that characterize one of the major neuropathologic changes in patients with Alzheimer's disease (AD). The sequence…”
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