Search Results - "Papp, Audrey C"

AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection by Papp, Audrey C, Azad, Abul K, Pietrzak, Maciej, Williams, Amanda, Handelman, Samuel K, Igo, Jr, Robert P, Stein, Catherine M, Hartmann, Katherine, Schlesinger, Larry S, Sadee, Wolfgang

“…Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood…”
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Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G by Zhang, Ying, Wang, Danxin, Johnson, Andrew D., Papp, Audrey C., Sadée, Wolfgang

“…As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction. Genetic variants of OPRM1…”
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Multiple Regulatory Variants Modulate Expression of 5-Hydroxytryptamine 2A Receptors in Human Cortex by Smith, Ryan M, Papp, Audrey C, Webb, Amy, Ruble, Cara L, Munsie, Leanne M, Nisenbaum, Laura K, Kleinman, Joel E, Lipska, Barbara K, Sadee, Wolfgang

“…Background The 5-hydroxytryptamine 2A receptor, encoded by HTR2A , is a major postsynaptic target for serotonin in the human brain and a therapeutic drug…”
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Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis by Pyle, Charlie J, Azad, Abul K, Papp, Audrey C, Sadee, Wolfgang, Knoell, Daren L, Schlesinger, Larry S

“…Tuberculosis (TB) is a global epidemic caused by the infection of human macrophages with the world's most deadly single bacterial pathogen, ( ). resides in a…”
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Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors by Pinsonneault, Julia K., Papp, Audrey C., Sadée, Wolfgang

“…A pVNTR repeat polymorphism located in the promoter region of the X-linked MAOA gene has been associated with mental disorders. To explore the effect of…”
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Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk by Papp, Audrey C, Pinsonneault, Julia K, Wang, Danxin, Newman, Leslie C, Gong, Yan, Johnson, Julie A, Pepine, Carl J, Kumari, Meena, Hingorani, Aroon D, Talmud, Philippa J, Shah, Sonia, Humphries, Steve E, Sadee, Wolfgang

“…Polymorphisms in and around the Cholesteryl Ester Transfer Protein (CETP) gene have been associated with HDL levels, risk for coronary artery disease (CAD),…”
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RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles by Webb, Amy, Papp, Audrey C, Curtis, Amanda, Newman, Leslie C, Pietrzak, Maciej, Seweryn, Michal, Handelman, Samuel K, Rempala, Grzegorz A, Wang, Daqing, Graziosa, Erica, Tyndale, Rachel F, Lerman, Caryn, Kelsoe, John R, Mash, Deborah C, Sadee, Wolfgang

“…We used RNA sequencing to analyze transcript profiles of ten autopsy brain regions from ten subjects. RNA sequencing techniques were designed to detect both…”
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Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms by Mascarenhas, Roshan, Pietrzak, Maciej, Smith, Ryan M, Webb, Amy, Wang, Danxin, Papp, Audrey C, Pinsonneault, Julia K, Seweryn, Michal, Rempala, Grzegorz, Sadee, Wolfgang

“…mRNA translation into proteins is highly regulated, but the role of mRNA isoforms, noncoding RNAs (ncRNAs), and genetic variants remains poorly understood…”
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Functional characterization of CYP2D6 enhancer polymorphisms by Wang, Danxin, Papp, Audrey C, Sun, Xiaochun

“…CYP2D6 metabolizes nearly 25% of clinically used drugs. Genetic polymorphisms cause large inter-individual variability in CYP2D6 enzyme activity and are…”
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Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2 by Mailman, Matthew D., Heinz, John W., Papp, Audrey C., Snyder, Pamela J., Sedra, Mary S., Wirth, Brunhilde, Burghes, Arthur H.M., Prior, Thomas W.

“…Purpose: This study describes SMN1 deletion frequency, carrier studies, and the effect of the modifying SMN2 gene on the spinal muscular atrophy (SMA)…”
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Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients by Wang, Danxin, Curtis, Amanda, Papp, Audrey C, Koletar, Susan L, Para, Michael F

“…Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states. SMX-induced…”
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Single nucleotide polymorphism genotyping using allele-specific PCR and fluorescence melting curves by Papp, Audrey C, Pinsonneault, Julia K, Cooke, Glen, Sadée, Wolfgang

“…We present a PCR method for identification of single nucleotide polymorphisms (SNPs), using allele-specific primers designed for selective amplification of…”
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Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene by Roe, Brian E, Tilley, Michael R, Gu, Howard H, Beversdorf, David Q, Sadee, Wolfgang, Haab, Timothy C, Papp, Audrey C

“…With recent advances in understanding of the neuroscience of risk taking, attention is now turning to genetic factors that may contribute to individual…”
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Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues by Wang, Danxin, Papp, Audrey C, Binkley, Philip F, Johnson, Julie A, Sadée, Wolfgang

“…OBJECTIVESThe voltage-dependent L-type calcium channel α-subunit 1c (Cav1.2, CACNA1C) undergoes extensive mRNA splicing, leading to numerous isoforms with…”
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A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection by Crouser, Elliott D, White, Peter, Caceres, Evelyn Guirado, Julian, Mark W, Papp, Audrey C, Locke, Landon W, Sadee, Wolfgang, Schlesinger, Larry S

“…Many aspects of pathogenic granuloma formation are poorly understood, requiring new relevant laboratory models that represent the complexity (genetics and…”
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IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model by Locke, Landon W, Crouser, Elliott D, White, Peter, Julian, Mark W, Caceres, Evelyn Guirado, Papp, Audrey C, Le, Van T, Sadee, Wolfgang, Schlesinger, Larry S

“…The mechanisms underlying abnormal granuloma formation in patients with sarcoidosis are complex and remain poorly understood. A novel in vitro human granuloma…”
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Intronic Polymorphisms Affecting Alternative Splicing of Human Dopamine D2 Receptor Are Associated with Cocaine Abuse by MOYER, Robert A, DANXIN WANG, PAPP, Audrey C, SMITH, Ryan M, DUQUE, Linda, MASH, Deborah C, SADEE, Wolfgang

“…The dopamine receptor D2 (encoded by DRD2) is implicated in susceptibility to mental disorders and cocaine abuse, but mechanisms responsible for this…”
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Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq by Suhy, Adam M., Webb, Amy, Papp, Audrey C., Geier, Ethan G., Sadee, Wolfgang

“…The blood-brain barrier (BBB) expresses numerous membrane transporters that supply needed nutrients to the central nervous system (CNS), consisting mostly of…”
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Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616 by Suhy, Adam, Hartmann, Katherine, Papp, Audrey C, Wang, Danxin, Sadee, Wolfgang

“…BACKGROUNDCholesteryl ester transfer protein (CETP) is involved in reverse cholesterol transport by exchanging cholesteryl esters for triglycerides between…”
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Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability by Wang, Danxin, Johnson, Andrew D, Papp, Audrey C, Kroetz, Deanna L, Sadée, Wolfgang

“…OBJECTIVESABCB1 (multidrug resistance 1 polypeptide, MDR1, Pgp) is a multispecific efflux transporter of drugs and xenobiotics. Among numerous polymorphisms in…”
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