Search Results - "Papenfuss, Tracey L"

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions by Amici, Stephanie A, Young, Nicholas A, Narvaez-Miranda, Janiret, Jablonski, Kyle A, Arcos, Jesus, Rosas, Lucia, Papenfuss, Tracey L, Torrelles, Jordi B, Jarjour, Wael N, Guerau-de-Arellano, Mireia

“…Macrophages and their monocyte precursors mediate innate immune responses and can promote a spectrum of phenotypes from pro-inflammatory to pro-resolving…”
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miR-221 Silencing Blocks Hepatocellular Carcinoma and Promotes Survival by PARK, Jong-Kook, KOGURE, Takayuki, SCHMITTGEN, Thomas D, NUOVO, Gerard J, JINMAI JIANG, LEI HE, KIM, Ji Hye, PHELPS, Mitch A, PAPENFUSS, Tracey L, CROCE, Carlo M, PATEL, Tushar

“…Patients with advanced hepatocellular carcinoma (HCC) face a dismal prognosis because of a lack of any effective therapies. To address this situation, we…”
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Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA by Julian, Mark W, Shao, Guohong, Bao, Shengying, Knoell, Daren L, Papenfuss, Tracey L, VanGundy, Zachary C, Crouser, Elliott D

“…Plasmacytoid dendritic cells (pDC) are potent APCs known to regulate immune responses to self-Ags, particularly DNA. The mitochondrial fraction of necrotic…”
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Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells by Julian, Mark W, Shao, Guohong, Vangundy, Zachary C, Papenfuss, Tracey L, Crouser, Elliott D

“…Mitochondrial transcription factor A (TFAM) is normally bound to and remains associated with mitochondrial DNA (mtDNA) when released from damaged cells. We…”
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Physiologic Doses of Bilirubin Contribute to Tolerance of Islet Transplants by Suppressing the Innate Immune Response by Adin, Christopher A., Vangundy, Zachary C., Papenfuss, Tracey L., Xu, Feng, Ghanem, Mostafa, Lakey, Jonathan, Hadley, Gregg A.

“…Bilirubin has been recognized as a powerful cytoprotectant when used at physiologic doses and was recently shown to have immunomodulatory effects in islet…”
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Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes by Julian, Mark W, Strange, Heather R, Ballinger, Megan N, Hotchkiss, Richard S, Papenfuss, Tracey L, Crouser, Elliott D

“…Immune suppression during critical illness predisposes to serious infections. We sought to determine the mechanisms regulating tolerance and cross-tolerance to…”
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Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs by Sherger, Matthew, Kisseberth, William, London, Cheryl, Olivo-Marston, Susan, Papenfuss, Tracey L

“…Myeloid derived suppressor cells (MDSCs) are a recently described population of immune cells that significantly contribute to the immunosuppression seen in…”
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Pregnancy Suppresses Experimental Autoimmune Encephalomyelitis through Immunoregulatory Cytokine Production by McClain, Melanie A, Gatson, NaTosha N, Powell, Nicole D, Papenfuss, Tracey L, Gienapp, Ingrid E, Song, Fei, Shawler, Todd M, Kithcart, Aaron, Whitacre, Caroline C

“…Women with multiple sclerosis (MS) often experience a decrease in relapse rate during pregnancy, most notably during the third trimester, with a flare of…”
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Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling by Peng, Haiyan, Guerau-de-Arellano, Mireia, Mehta, Veela B., Yang, Yuhong, Huss, David J., Papenfuss, Tracey L., Lovett-Racke, Amy E., Racke, Michael K.

“…Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials. A reduction of IFN-γ-producing CD4+ T cells is observed in…”
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Toxicologic Pathology Forum: Considerations Regarding Determination of Adversity for Immunopathology Findings in Nonclinical Toxicology Studies with Immune-Modulating Therapeutics by Papenfuss, Tracey L., Himmel, Lauren, Kuper, C. Frieke, Mohanan, Sunish, Harleman, Johannes, Elmore, Susan A.

“…The evaluation of changes in the immune system serves to determine the efficacy and potential immunotoxicologic effects of new products under development…”
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MicroRNA 155 Contributes to Host Immunity against Leishmania donovani but Is Not Essential for Resolution of Infection by Varikuti, Sanjay, Natarajan, Gayathri, Volpedo, Greta, Singh, Bhawana, Hamza, Omar, Messick, Gretchen V, Guerau-de-Arellano, Mireia, Papenfuss, Tracey L, Oghumu, Steve, Satoskar, Abhay R

“…CD4 T helper 1 (Th1) cells producing interferon gamma (IFN-γ) are critical for the resolution of visceral leishmaniasis (VL). MicroRNA 155 (miR155) promotes…”
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Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity by Papenfuss, Tracey L, Powell, Nicole D, McClain, Melanie A, Bedarf, Ashley, Singh, Amber, Gienapp, Ingrid E, Shawler, Todd, Whitacre, Caroline C

“…Chronic inflammation contributes to numerous diseases, and regulation of inflammation is crucial for disease control and resolution. Sex hormones have potent…”
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The Potent ITK/BTK Inhibitor Ibrutinib Is Effective for the Treatment of Experimental Visceral Leishmaniasis Caused by Leishmania donovani by Varikuti, Sanjay, Volpedo, Greta, Saljoughian, Noushin, Hamza, Omar M, Halsey, Gregory, Ryan, Nathan M, Sedmak, Bren E, Seidler, Gabriella R, Papenfuss, Tracey L, Oghumu, Steve, Satoskar, Abhay R

“…A new paradigm has emerged for treating infections, which focuses on targeting host pathways that are critical for pathogen invasion, survival, and…”
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In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines from Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene by Lanigan, Lisa G., Hildreth, Blake E., Dirksen, Wessel P., Simmons, Jessica K., Martin, Chelsea K., Werbeck, Jillian L., Thudi, Nandu K., Papenfuss, Tracey L., Boyaka, Prosper N., Toribio, Ramiro E., Ward, Jerrold M., Weilbaecher, Katherine N., Rosol, Thomas J.

“…Human T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukemia, a disease commonly associated with hypercalcemia and osteolysis. There is no effective…”
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Treatment of Experimental Autoimmune Encephalomyelitis by Codelivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles by Peine, Kevin J, Guerau-de-Arellano, Mireia, Lee, Priscilla, Kanthamneni, Naveen, Severin, Mary, Probst, G. Duane, Peng, Haiyan, Yang, Yuhong, Vangundy, Zachary, Papenfuss, Tracey L, Lovett-Racke, Amy E, Bachelder, Eric M, Ainslie, Kristy M

“…Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system that can cause loss of motor function and is thought to result,…”
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IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production by Jaime-Ramirez, Alena Cristina, Mundy-Bosse, Bethany L, Kondadasula, SriVidya, Jones, Natalie B, Roda, Julie M, Mani, Aruna, Parihar, Robin, Karpa, Volodymyr, Papenfuss, Tracey L, LaPerle, Krista M, Biller, Elizabeth, Lehman, Amy, Chaudhury, Abhik Ray, Jarjoura, David, Burry, Richard W, Carson, 3rd, William E

“…The antitumor effects of therapeutic mAbs may depend on immune effector cells that express FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production…”
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Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis by Papenfuss, Tracey L., Kithcart, Aaron P., Powell, Nicole D., McClain, Melanie A., Gienapp, Ingrid E., Shawler, Todd M., Whitacre, Caroline C.

“…Dendritic cells (DCs) bridge the innate and adaptive immune response, are uniquely capable of priming naïve T cells, and play a critical role in the initiation…”
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Liposomal resiquimod for the treatment of Leishmania donovani infection by Peine, Kevin J, Gupta, Gaurav, Brackman, Deanna J, Papenfuss, Tracey L, Ainslie, Kristy M, Satoskar, Abhay R, Bachelder, Eric M

“…The imidazoquinoline family of drugs are Toll-like receptor 7/8 agonists that have previously been used in the treatment of cutaneous leishmaniasis. Because of…”
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Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis by Varikuti, Sanjay, Natarajan, Gayathri, Oghumu, Steve, Sperling, Rachel H., Moretti, Ellen, Stock, James, Papenfuss, Tracey L., Satoskar, Abhay R.

“…•CXCR3 transgenic mice show increased accumulation of T cells in their spleen following L. donovani infection.•Hepatic granuloma formation is impaired in CXCR3…”
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STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis by Oghumu, Steve, Gupta, Gaurav, Snider, Heidi M., Varikuti, Sanjay, Terrazas, César A., Papenfuss, Tracey L., Kaplan, Mark H., Satoskar, Abhay R.

“…We and others have previously shown that IL‐12 is indispensable for immunity and is required for the optimal antiparasitic activity of antimonials in…”
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