Search Results - "Papazyan, Romeo"

Genetic and epigenomic mechanisms of mammalian circadian transcription by Papazyan, Romeo, Zhang, Yuxiang, Lazar, Mitchell A

“…In this Review, the authors consider the functions of key clock transcription factors and the epigenetic regulatory mechanisms that direct circadian gene…”
Get full text

FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver by Papazyan, Romeo, Liu, Xueqing, Liu, Jingwen, Dong, Bin, Plummer, Emily M., Lewis, Ronald D., Roth, Jonathan D., Young, Mark A.

“…Obeticholic acid (OCA) is a selective farnesoid X receptor (FXR) agonist that regulates bile acid and lipid metabolism. FXR activation induces distinct changes…”
Get full text

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes by Guan, Dongyin, Xiong, Ying, Borck, Patricia C., Jang, Cholsoon, Doulias, Paschalis-Thomas, Papazyan, Romeo, Fang, Bin, Jiang, Chunjie, Zhang, Yuxiang, Briggs, Erika R., Hu, Wenxiang, Steger, David, Ischiropoulos, Harry, Rabinowitz, Joshua D., Lazar, Mitchell A.

“…Overnutrition disrupts circadian metabolic rhythms by mechanisms that are not well understood. Here, we show that diet-induced obesity (DIO) causes massive…”
Get full text

Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome by Hamilton, Eileen P, Kapusta, Aurélie, Huvos, Piroska E, Bidwell, Shelby L, Zafar, Nikhat, Tang, Haibao, Hadjithomas, Michalis, Krishnakumar, Vivek, Badger, Jonathan H, Caler, Elisabet V, Russ, Carsten, Zeng, Qiandong, Fan, Lin, Levin, Joshua Z, Shea, Terrance, Young, Sarah K, Hegarty, Ryan, Daza, Riza, Gujja, Sharvari, Wortman, Jennifer R, Birren, Bruce W, Nusbaum, Chad, Thomas, Jainy, Carey, Clayton M, Pritham, Ellen J, Feschotte, Cédric, Noto, Tomoko, Mochizuki, Kazufumi, Papazyan, Romeo, Taverna, Sean D, Dear, Paul H, Cassidy-Hanley, Donna M, Xiong, Jie, Miao, Wei, Orias, Eduardo, Coyne, Robert S

“…The germline genome of the binucleated ciliate undergoes programmed chromosome breakage and massive DNA elimination to generate the somatic genome. Here, we…”
Get full text

Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH by Roth, Jonathan D., Veidal, Sanne S., Fensholdt, Louise K. D., Rigbolt, Kristoffer T. G., Papazyan, Romeo, Nielsen, Jens Christian, Feigh, Michael, Vrang, Niels, Young, Mark, Jelsing, Jacob, Adorini, Luciano, Hansen, Henrik H.

“…Obeticholic acid (OCA) and elafibranor (ELA) are selective and potent agonists for the farnesoid X receptor (FXR) and dual peroxisome proliferator-activated…”
Get full text

Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP by Papazyan, Romeo, Sun, Zheng, Kim, Yong Hoon, Titchenell, Paul M., Hill, David A., Lu, Wenyun, Damle, Manashree, Wan, Min, Zhang, Yuxiang, Briggs, Erika R., Rabinowitz, Joshua D., Lazar, Mitchell A.

“…Liver fat accumulation precedes non-alcoholic steatohepatitis, an increasing cause of end-stage liver disease. Histone deacetylase 3 (HDAC3) is required for…”
Get full text

Human Fecal Bile Acid Analysis after Investigational Microbiota-Based Live Biotherapeutic Delivery for Recurrent Clostridioides difficile Infection by Papazyan, Romeo, Ferdyan, Nicky, Srinivasan, Karthik, Gonzalez, Carlos, Shannon, William D, Blount, Ken, Fuchs, Bryan C

“…Microbiome-based therapeutics are increasingly evaluated as a strategy to reduce recurrent infection (rCDI), with proposed mechanisms including restoration of…”
Get full text

Reader domain specificity and lysine demethylase-4 family function by Su, Zhangli, Wang, Fengbin, Lee, Jin-Hee, Stephens, Kimberly E., Papazyan, Romeo, Voronina, Ekaterina, Krautkramer, Kimberly A., Raman, Ana, Thorpe, Jeremy J., Boersma, Melissa D., Kuznetsov, Vyacheslav I., Miller, Mitchell D., Taverna, Sean D., Phillips, George N., Denu, John M.

“…The KDM4 histone demethylases are conserved epigenetic regulators linked to development, spermatogenesis and tumorigenesis. However, how the KDM4 family…”
Get full text

Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis by Papazyan, Romeo, Voronina, Ekaterina, Chapman, Jessica R, Luperchio, Teresa R, Gilbert, Tonya M, Meier, Elizabeth, Mackintosh, Samuel G, Shabanowitz, Jeffrey, Tackett, Alan J, Reddy, Karen L, Coyne, Robert S, Hunt, Donald F, Liu, Yifan, Taverna, Sean D

“…Despite the well-established role of heterochromatin in protecting chromosomal integrity during meiosis and mitosis, the contribution and extent of…”
Get full text

Requirement of the TRPC1 Cation Channel in the Generation of Transient Ca2+ Oscillations by the Calcium-sensing Receptor by Rey, Osvaldo, Young, Steven H., Papazyan, Romeo, Shapiro, Mark S., Rozengurt, Enrique

“…The calcium-sensing receptor (CaR) is an allosteric protein that responds to extracellular Ca2+ ([Ca2+]o) and aromatic amino acids with the production of…”
Get full text

The Nuclear Import of Protein Kinase D3 Requires Its Catalytic Activity by Rey, Osvaldo, Papazyan, Romeo, Waldron, Richard T., Young, Steven H., Lippincott-Schwartz, Jennifer, Jacamo, Rodrigo, Rozengurt, Enrique

“…The protein kinase D (PKD) family consists of three serine/threonine protein kinases termed PKD, PKD2, and PKD3, which are similar in overall structure and…”
Get full text

Su1596: MICROBIOME AND BILE ACID RESTORATION WAS CONSISTENT ACROSS THREE CLINICAL TRIALS OF RBX2660 FOR RECURRENT CLOSTRIDIOIDES DIFFICILE INFECTION: A COMBINED ANALYSIS by Blount, Ken, Hau, Heidi, Papazyan, Romeo, Fuchs, Bryan, Shannon, Bill, Gonzalez, Carlos

Get full text

The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ by Zhang, Yuxiang, Papazyan, Romeo, Damle, Manashree, Fang, Bin, Jager, Jennifer, Feng, Dan, Peed, Lindsey C, Guan, Dongyin, Sun, Zheng, Lazar, Mitchell A

“…Liver lipid metabolism is under intricate temporal control by both the circadian clock and feeding. The interplay between these two mechanisms is not clear…”
Get full text

Microbiome and Metabolome Restoration After Administration of Fecal Microbiota, Live-jslm (REBYOTA®) for Preventing Recurrent Clostridioides difficile Infection by Blount, Ken F, Papazyan, Romeo, Ferdyan, Nicky, Srinivasan, Karthik, Gonzalez, Carlos, Shannon, William D, Fuchs, Bryan C

“…Microbiota-based treatments are effective in preventing recurrent Clostridioides difficile infection (rCDI). Fecal microbiota, live-jslm (REBYOTA®; RBL,…”
Get full text

pH Dependence of a GPR4 Selective Antagonist Hampers Its Therapeutic Potential by Stalewski, Jacek, Shih, Amy Y, Papazyan, Romeo, Ramirez, Jocelyn, Ibanez, Gerardo, Hsiao, Peng, Yue, Yong, Yin, Jun, Badger, Calen, Wu, Shije, Ueki, Akemi, Fuchs, Bryan C, Rives, Marie-Laure

“…Inflammatory bowel disease (IBD) is characterized by chronic mucosal inflammation of the gastrointestinal tract and is associated with extracellular…”
Get full text

LBP-40-Development of Oligonucleotide-Based miR-132 Antagonists for the Treatment of NASH by Papazyan, Romeo, Kinberger, Garth, Wang, Danling, Lang, Graham, Gogas, Kathy, Wright, Timothy, Zhu, Shoutian

Get full text

1039. Rapid Restoration of Bile Acid Compositions After Treatment with RBX2660 for Recurrent Clostridioides difficile Infection—Results from the PUNCH CD3 Phase 3 Trial by Papazyan, Romeo, Fuchs, Bryan, Blount, Ken, Gonzalez, Carlos, Shannon, Bill

“…Abstract Background Microbiota-based treatments are increasingly evaluated as a strategy to reduce recurrence of Clostridioides difficile infection (rCDI), and…”
Get full text

29. Rapid Restoration of Bile Acid Compositions After Treatment with Investigational Microbiota-based Therapeutic RBX2660 for Recurrent clostrioides Difficile Infection by Ferdyan, Nicky, Papazyan, Romeo, Walsh, Dana, Klein, Sarah, Qi, Steve, Blount, Ken, Srinivasan, Karthik, Fuchs, Bryan

“…Abstract Background Recurrent Clostrioides difficile infection (rCDI) is a public health threat associated with intestinal microbiome disruption (dysbiosis),…”
Get full text

Separation and purification of multiply acetylated proteins using cation-exchange chromatography by Papazyan, Romeo, Taverna, Sean D

“…High-performance liquid chromatography (HPLC) is extremely useful for the study of proteins and the characterization of their posttranslational modifications…”
Get more information

Azalysine Analogues as Probes for Protein Lysine Deacetylation and Demethylation by Dancy, Blair C. R, Ming, Shonoi A, Papazyan, Romeo, Jelinek, Christine A, Majumdar, Ananya, Sun, Yan, Dancy, Beverley M, Drury, William J, Cotter, Robert J, Taverna, Sean D, Cole, Philip A

“…Reversible lysine acetylation and methylation regulate the function of a wide variety of proteins, including histones. Here, we have synthesized…”
Get full text