Transplantation of Renal Allograft After Removal of Renal Cell Carcinoma: Case Report and Review of the Literature

With the rising incidence of end-stage renal disease in the United States, patients needing renal transplants are waiting longer for increasingly scarce grafts. Formerly, the general practice was to avoid organs with tumors for transplant because of the risk of malignancy transmission to the recipie...

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Bibliographic Details
Published in:	Experimental and clinical transplantation Vol. 19; no. 7; pp. 732 - 735
Main Authors:	Tran, Anthony P, Martins, Paulo N, Papazian, Zachary G, Vanguri, Vijay K, Movahedi, Babak, Fan, Pang-Yen, Bodziak, Kenneth A, Yates, Jennifer K, Sokoloff, Mitchell H, Bozorgzadeh, Adel
Format:	Journal Article
Language:	English
Published:	Turkey Başkent Üniversitesi 01-07-2021
Subjects:	Adult Aged Allografts - pathology Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery Female Humans Kidney Failure, Chronic - complications Kidney Failure, Chronic - diagnosis Kidney Failure, Chronic - surgery Kidney Neoplasms - pathology Kidney Transplantation - adverse effects Male Nephrectomy - adverse effects Tıp Treatment Outcome United States United States Ankara Türkiye Kidney masses Living donor Kidney transplantation
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Summary:	With the rising incidence of end-stage renal disease in the United States, patients needing renal transplants are waiting longer for increasingly scarce grafts. Formerly, the general practice was to avoid organs with tumors for transplant because of the risk of malignancy transmission to the recipient. However, with comprehensive donor selection and a small-sized primary tumor, the positive outcomes of transplant outweigh the risks of transmission after a partial nephrectomy. In our case, a 31-year-old woman, the daughter of the recipient, underwent a laparoscopic nephrectomy with an existing 8-mm tumor later confirmed as renal cell carcinoma. An ex vivo tumor enucleation was performed before the allograft was transplanted into the 69-year-old patient with endstage renal disease. At last follow-up, graft function has remained excellent with no evidence of local recurrence or metastasis in both the donor and recipient. Here, we describe our case and perform a literature review on the incidence and management of renal allografts with incidentally detected renal cell carcinoma during transplant.
ISSN:	1304-0855 2146-8427
DOI:	10.6002/ect.2018.0215