Cardiovascular autonomic control in Becker muscular dystrophy

Cardiovascular autonomic control in Becker muscular dystrophy

Although autonomic symptoms are not prominent in dystrophinopathies, a reduced vagal activity and an enhanced sympathetic tone have been found in Duchenne muscular dystrophy. Twenty patients with Becker muscular dystrophy (BMD) were investigated by a battery of six cardiovascular autonomic tests (be...

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Bibliographic Details
Published in:Journal of the neurological sciences Vol. 186; no. 1; pp. 45 - 49
Main Authors: Vita, Giuseppe, Di Leo, Rita, De Gregorio, Cesare, Papalia, Alessandra, Rodolico, Carmelo, Coglitore, Sebastiano, Messina, Corrado
Format: Journal Article
Language:English
Published: Shannon Elsevier B.V 01-05-2001
Elsevier Science
Subjects:
Adolescent
Adult
Autonomic nervous system
Autonomic Nervous System - physiopathology
Becker muscular dystrophy
Biological and medical sciences
Blood Pressure
Cardiovascular tests
Child
Diseases of striated muscles. Neuromuscular diseases
Heart Rate
Heart rate variability
Humans
Medical sciences
Middle Aged
Muscular Dystrophy, Duchenne - physiopathology
Neurology
Power spectral analysis
Valsalva Maneuver
Power spectral analysis
Becker muscular dystrophy
Cardiovascular tests
Autonomic nervous system
Heart rate variability
Human
Heart rate
Neuromuscular diseases
Nervous system diseases
Cardiovascular control
Pathophysiology
Genetic disease
Power spectrum
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Summary:Although autonomic symptoms are not prominent in dystrophinopathies, a reduced vagal activity and an enhanced sympathetic tone have been found in Duchenne muscular dystrophy. Twenty patients with Becker muscular dystrophy (BMD) were investigated by a battery of six cardiovascular autonomic tests (beat-to-beat variability during quiet breathing and deep breathing, heart rate responses to Valsalva maneuver and standing, blood pressure responses to standing and sustained handgrip) and power spectral analysis (PSA) of heart rate variability. Although 11 patients revealed abnormal findings at some cardiovascular tests, none of them had a definite autonomic damage, as indicated by two or more abnormal tests. The mean results of the single tests did not differ from normal controls, except for the beat-to-beat variability during quiet breathing, which was significantly higher in BMD ( p<0.05). Such finding was confirmed by a significantly higher total variance ( p<0.05), indicating an increased parasympathetic activity. Spectral components were not significantly different from normal controls. PSA values were not influenced by age, functional ability score or presence of heart abnormalities. Our data suggest that autonomic involvement does not represent a major finding in BMD.
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ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(01)00500-7