Search Results - "Papakonstantinou, Maria P"
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Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein
Published in Proceedings of the National Academy of Sciences - PNAS (28-11-2017)“…Activation of heterotrimeric G proteins by cytoplasmic nonreceptor proteins is an alternative to the classical mechanism via G protein-coupled receptors…”
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The Gαi-GIV binding interface is a druggable protein-protein interaction
Published in Scientific reports (17-08-2017)“…Heterotrimeric G proteins are usually activated by the guanine-nucleotide exchange factor (GEF) activity of GPCRs. However, some non-receptor proteins are also…”
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Expression and membrane topology of Anopheles gambiae odorant receptors in lepidopteran insect cells
Published in PloS one (03-11-2010)“…A lepidopteran insect cell-based expression system has been employed to express three Anopheles gambiae odorant receptors (ORs), OR1 and OR2, which respond to…”
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Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits
Published in Molecular cell (20-07-2023)“…G-protein-coupled receptors (GPCRs) mediate neuromodulation through the activation of heterotrimeric G proteins (Gαβγ). Classical models depict that G protein…”
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Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate μ- and δ-opioid receptor signaling
Published in Cellular signalling (01-07-2009)“…In vitro studies have shown that the Regulator of G protein Signaling 4 (RGS4) interacts with the C-termini of μ- and δ-opioid receptors (μ-OR, δ-OR)…”
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Pharmacological Implications of Adenosine 2A and Dopamine Type 2 Receptor Heteromerization
Published in Biophysical journal (07-02-2020)Get full text
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PS II-4: RGS2 and RGS4 proteins act as novel modulators of κ and δ opioid receptors signaling
Published in Pharmacological reports (2011)Get full text
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RGS2 and RGS4 proteins act as novel modulators of κ and δ opioid receptors signaling
Published in Pharmacological reports (01-01-2011)Get full text
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