Search Results - "Papaconstantinou, John"

The Role of Signaling Pathways of Inflammation and Oxidative Stress in Development of Senescence and Aging Phenotypes in Cardiovascular Disease by Papaconstantinou, John

“…The ASK1-signalosome→p38 MAPK and SAPK/JNK signaling networks promote senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to…”
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p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes by Menon, Ramkumar, Papaconstantinou, John

“…Spontaneous preterm birth (PTB) and preterm premature rupture of the membranes (pPROM) remain as a major clinical and therapeutic problem for intervention and…”
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Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress by Sheller, Samantha, Papaconstantinou, John, Urrabaz-Garza, Rheanna, Richardson, Lauren, Saade, George, Salomon, Carlos, Menon, Ramkumar

“…At term, the signals of fetal maturity and feto-placental tissue aging prompt uterine readiness for delivery by transitioning quiescent myometrium to an active…”
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HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes by Bredeson, Sarah, Papaconstantinou, John, Deford, James H, Kechichian, Talar, Syed, Tariq A, Saade, George R, Menon, Ramkumar

“…Spontaneous preterm birth (PTB) and preterm prelabor rupture of membranes (pPROM) are major pregnancy complications often associated with a fetal inflammatory…”
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Senescence of primary amniotic cells via oxidative DNA damage by Menon, Ramkumar, Boldogh, Istvan, Urrabaz-Garza, Rheanna, Polettini, Jossimara, Syed, Tariq Ali, Saade, George R, Papaconstantinou, John, Taylor, Robert N

“…Oxidative stress is a postulated etiology of spontaneous preterm birth (PTB) and preterm prelabor rupture of the membranes (pPROM); however, the precise…”
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Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways by Brobey, Reynolds K, German, Dwight, Sonsalla, Patricia K, Gurnani, Prem, Pastor, Johanne, Hsieh, C-C, Papaconstantinou, John, Foster, Philip P, Kuro-o, Makoto, Rosenblatt, Kevin P

“…Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant…”
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Lifespan Extension and Delayed Immune and Collagen Aging in Mutant Mice with Defects in Growth Hormone Production by Flurkey, Kevin, Papaconstantinou, John, Miller, Richard A., Harrison, David E.

“…Single-gene mutations that extend lifespan provide valuable tools for the exploration of the molecular basis for age-related changes in cell and tissue…”
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Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers by Nuss, Jonathan E., Choksi, Kashyap B., DeFord, James H., Papaconstantinou, John

“…The endoplasmic reticulum (ER) is a target for endogenously generated reactive oxygen species (ROS) during aging. We have previously shown that the ER…”
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The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging by Hsieh, C-C, Kuro-o, Makoto, Rosenblatt, Kevin P, Brobey, Reynolds, Papaconstantinou, John

“…Reactive oxygen species (ROS) and elevated levels of p38 MAPK activity accelerate physiological aging. This emphasizes the importance of understanding the…”
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Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes by Choksi, Kashyap B., Nuss, Jonathan E., DeFord, James H., Papaconstantinou, John

“…Age-associated mitochondrial dysfunction is a major source of reactive oxygen species (ROS) and oxidative modification to proteins. Mitochondrial electron…”
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Activation of senescence and aging characteristics by mitochondrially generated ROS: How are they linked? by Papaconstantinou, John, Hsieh, Ching-Chyuan

“…This article discusses the molecular mechanism(s) that link oxidative stress (ROS) due to mitochondrial dysfunction to the activation of the ROS-sensitive…”
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Carbonylation of ER chaperone proteins in aged mouse liver by Rabek, Jeffrey P., Boylston III, William H., Papaconstantinou, John

“…Progressive accumulation of oxidative damage to macromolecules in aged tissues is thought to contribute to the decline in tissue function characteristic of the…”
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Age-Dependent Deficiency in Import of Mitochondrial DNA Glycosylases Required for Repair of Oxidatively Damaged Bases by Szczesny, Bartosz, Hazra, Tapas K., Papaconstantinou, John, Mitra, Sankar, Boldogh, Istvan

“…The mitochondria are the major source of chronic oxidative stress, which has been implicated in the aging process. Along with other cellular changes, aged…”
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Mitochondrial electron transport chain functions in long-lived Ames dwarf mice by Choksi, Kashyap B, Nuss, Jonathan E, DeFord, James H, Papaconstantinou, John

“…The age-associated decline in tissue function has been attributed to ROS-mediated oxidative damage due to mitochondrial dysfunction. The long-lived Ames dwarf…”
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Age-associated Differences in Cardiovascular Inflammatory Gene Induction during Endotoxic Stress by Saito, H, Papaconstantinou, J

“…Upon physiological stress, families of stress response genes are activated as natural defense mechanisms. Here, we show that induction of specific inflammatory…”
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Aging, oxidative responses, and proliferative capacity in cultured mouse aortic smooth muscle cells by Moon, S K, Thompson, L J, Madamanchi, N, Ballinger, S, Papaconstantinou, J, Horaist, C, Runge, M S, Patterson, C

“…The cellular mechanisms that contribute to the acceleration of atherosclerosis in aging populations are poorly understood, although it is hypothesized that…”
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Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid by Hsieh, Ching-Chyuan, Rosenblatt, Judah I., Papaconstantinou, John

“…Mitochondrial dysfunction has been identified as a major source of oxidative stress in aged tissues. In this study we asked whether activities of components of…”
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The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid by Hsieh, Ching-Chyuan, Papaconstantinou, John

“…Since mitochondrial dysfunction is a major source of oxidative stress in aged tissues, we asked whether the basal activities of stress response signaling…”
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High-Throughput Liquid−Liquid Fractionation of Multiple Protein Post-Translational Modifications by DeFord, James H, Nuss, Jonathan E, Amaning, James, English, Robert D, Tjernlund, Don, Papaconstantinou, John

“…Post-translational protein modifications have contributed significantly to the identification of macromolecular biomarkers of biological processes. We have…”
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Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I by Grompe, Markus, Lindstedt, Sven, Al-Dhalimy, Muhsen, Kennaway, Nancy G, Papaconstantinou, John, Torres-Ramos, Carlos A, Ou, Ching-Nau, Finegold, Milton

“…Hereditary tyrosinaemia type I, a severe autosomal recessive metabolic disease, affects the liver and kidneys and is caused by deficiency of…”
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