Search Results - "Papachristou, Evangelia K."

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response by Nagarajan, Sankari, Rao, Shalini V., Sutton, Joseph, Cheeseman, Danya, Dunn, Shanade, Papachristou, Evangelia K., Prada, Jose-Enrique Gonzalez, Couturier, Dominique-Laurent, Kumar, Sanjeev, Kishore, Kamal, Chilamakuri, Chandra Sekhar Reddy, Glont, Silvia-Elena, Archer Goode, Emily, Brodie, Cara, Guppy, Naomi, Natrajan, Rachael, Bruna, Alejandra, Caldas, Carlos, Russell, Alasdair, Siersbæk, Rasmus, Yusa, Kosuke, Chernukhin, Igor, Carroll, Jason S.

“…Using genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screens to understand endocrine drug resistance, we discovered ARID1A and…”
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A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes by Papachristou, Evangelia K., Kishore, Kamal, Holding, Andrew N., Harvey, Kate, Roumeliotis, Theodoros I., Chilamakuri, Chandra Sekhar Reddy, Omarjee, Soleilmane, Chia, Kee Ming, Swarbrick, Alex, Lim, Elgene, Markowetz, Florian, Eldridge, Matthew, Siersbaek, Rasmus, D’Santos, Clive S., Carroll, Jason S.

“…Understanding the dynamics of endogenous protein–protein interactions in complex networks is pivotal in deciphering disease mechanisms. To enable the in-depth…”
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CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death by Pavlou, Sofia, Foskolou, Stefanie, Patikas, Nikolaos, Field, Sarah F., Papachristou, Evangelia K., Santos, Clive D’, Edwards, Abigail R., Kishore, Kamal, Ansari, Rizwan, Rajan, Sandeep S., Fernandes, Hugo J. R., Metzakopian, Emmanouil

“…Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of…”
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TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions by Broome, Rebecca, Chernukhin, Igor, Jamieson, Stacey, Kishore, Kamal, Papachristou, Evangelia K., Mao, Shi-Qing, Tejedo, Carmen Gonzalez, Mahtey, Areeb, Theodorou, Vasiliki, Groen, Arnoud J., D’Santos, Clive, Balasubramanian, Shankar, Farcas, Anca Madalina, Siersbæk, Rasmus, Carroll, Jason S.

“…Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function,…”
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Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia by Simeoni, Fabrizio, Romero-Camarero, Isabel, Camera, Francesco, Amaral, Fabio M.R., Sinclair, Oliver J., Papachristou, Evangelia K., Spencer, Gary J., Lie-A-Ling, Michael, Lacaud, Georges, Wiseman, Daniel H., Carroll, Jason S., Somervaille, Tim C.P.

“…Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of…”
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Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer by Memon, Danish, Gill, Michael B., Papachristou, Evangelia K., Ochoa, David, D’Santos, Clive S., Miller, Martin L., Beltrao, Pedro

“…Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression, albeit with often uncharacterized roles in altering cell…”
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Identification of ChIP-seq and RIME grade antibodies for Estrogen Receptor alpha by Glont, Silvia-E, Papachristou, Evangelia K, Sawle, Ashley, Holmes, Kelly A, Carroll, Jason S, Siersbaek, Rasmus

“…Estrogen Receptor alpha (ERα) plays a major role in most breast cancers, and it is the target of endocrine therapies used in the clinic as standard of care for…”
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Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study by Zeidan, Bashar, Manousopoulou, Antigoni, Garay-Baquero, Diana J, White, Cory H, Larkin, Samantha E T, Potter, Kathleen N, Roumeliotis, Theodoros I, Papachristou, Evangelia K, Copson, Ellen, Cutress, Ramsey I, Beers, Stephen A, Eccles, Diana, Townsend, Paul A, Garbis, Spiros D

“…Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer…”
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ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia by Dickerson, Kirsten M, Qu, Chunxu, Gao, Qingsong, Iacobucci, Ilaria, Gu, Zhaohui, Yoshihara, Hiroki, Backhaus, Emily A, Chang, Yunchao, Janke, Laura J, Xu, Beisi, Wu, Gang, Papachristou, Evangelia K, D'Santos, Clive S, Roberts, Kathryn G, Mullighan, Charles G

“…ZNF384-rearranged fusion oncoproteins (FO) define a subset of lineage ambiguous leukemias, but their mechanistic role in leukemogenesis and lineage ambiguity…”
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Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects by Tyrakis, Petros A., Yurkovich, Marie E., Sciacovelli, Marco, Papachristou, Evangelia K., Bridges, Hannah R., Gaude, Edoardo, Schreiner, Alexander, D’Santos, Clive, Hirst, Judy, Hernandez-Fernaud, Juan, Springett, Roger, Griffiths, John R., Frezza, Christian

“…Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding…”
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IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis by Siersbæk, Rasmus, Scabia, Valentina, Nagarajan, Sankari, Chernukhin, Igor, Papachristou, Evangelia K., Broome, Rebecca, Johnston, Simon J., Joosten, Stacey E.P., Green, Andrew R., Kumar, Sanjeev, Jones, Julia, Omarjee, Soleilmane, Alvarez-Fernandez, Ruben, Glont, Silvia, Aitken, Sarah J., Kishore, Kamal, Cheeseman, Danya, Rakha, Emad A., D'Santos, Clive, Zwart, Wilbert, Russell, Alasdair, Brisken, Cathrin, Carroll, Jason S.

“…The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a key oncogenic pathway, which has been thought to be functionally connected to…”
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Asparagine bioavailability governs metastasis in a model of breast cancer by Knott, Simon R. V., Wagenblast, Elvin, Khan, Showkhin, Kim, Sun Y., Soto, Mar, Wagner, Michel, Turgeon, Marc-Olivier, Fish, Lisa, Erard, Nicolas, Gable, Annika L., Maceli, Ashley R., Dickopf, Steffen, Papachristou, Evangelia K., D’Santos, Clive S., Carey, Lisa A., Wilkinson, John E., Harrell, J. Chuck, Perou, Charles M., Goodarzi, Hani, Poulogiannis, George, Hannon, Gregory J.

“…In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that…”
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer by Shu, Shaokun, Wu, Hua-Jun, Ge, Jennifer Y., Zeid, Rhamy, Harris, Isaac S., Jovanović, Bojana, Murphy, Katherine, Wang, Binbin, Qiu, Xintao, Endress, Jennifer E., Reyes, Jaime, Lim, Klothilda, Font-Tello, Alba, Syamala, Sudeepa, Xiao, Tengfei, Reddy Chilamakuri, Chandra Sekhar, Papachristou, Evangelia K., D’Santos, Clive, Anand, Jayati, Hinohara, Kunihiko, Li, Wei, McDonald, Thomas O., Luoma, Adrienne, Modiste, Rebecca J., Nguyen, Quang-De, Michel, Brittany, Cejas, Paloma, Kadoch, Cigall, Jaffe, Jacob D., Wucherpfennig, Kai W., Qi, Jun, Liu, X. Shirley, Long, Henry, Brown, Myles, Carroll, Jason S., Brugge, Joan S., Bradner, James, Michor, Franziska, Polyak, Kornelia

“…BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer types, but inherent and acquired…”
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Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis by Demond, Hannah, Hanna, Courtney W, Castillo-Fernandez, Juan, Santos, Fátima, Papachristou, Evangelia K, Segonds-Pichon, Anne, Kishore, Kamal, Andrews, Simon, D'Santos, Clive S, Kelsey, Gavin

“…EHMT1 (also known as GLP) is a multifunctional protein, best known for its role as an H3K9me1 and H3K9me2 methyltransferase through its reportedly obligatory…”
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The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer by Patel, Saroor A., Hirosue, Shoko, Rodrigues, Paulo, Vojtasova, Erika, Richardson, Emma K., Ge, Jianfeng, Syafruddin, Saiful E., Speed, Alyson, Papachristou, Evangelia K., Baker, David, Clarke, David, Purvis, Stephenie, Wesolowski, Ludovic, Dyas, Anna, Castillon, Leticia, Caraffini, Veronica, Bihary, Dóra, Yong, Cissy, Harrison, David J., Stewart, Grant D., Machiela, Mitchell J., Purdue, Mark P., Chanock, Stephen J., Warren, Anne Y., Samarajiwa, Shamith A., Carroll, Jason S., Vanharanta, Sakari

“…Large-scale human genetic data 1 – 3 have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here,…”
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EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis by Peluffo, Guillermo, Subedee, Ashim, Harper, Nicholas W, Kingston, Natalie, Jovanović, Bojana, Flores, Felipe, Stevens, Laura E, Beca, Francisco, Trinh, Anne, Chilamakuri, Chandra Sekhar Reddy, Papachristou, Evangelia K, Murphy, Katherine, Su, Ying, Marusyk, Andriy, D'Santos, Clive S, Rueda, Oscar M, Beck, Andrew H, Caldas, Carlos, Carroll, Jason S, Polyak, Kornelia

“…To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in…”
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Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer by Goodman, Merit L, Trinca, Gloria M, Walter, Katherine R, Papachristou, Evangelia K, D'Santos, Clive S, Li, Tianbao, Liu, Qi, Lai, Zhao, Chalise, Prabhakar, Madan, Rashna, Fan, Fang, Markiewicz, Mary A, Jin, Victor X, Carroll, Jason S, Hagan, Christy R

“…Why some tumors remain indolent and others progress to clinical relevance remains a major unanswered question in cancer biology. IFN signaling in nascent…”
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Molecular Determinants of Sensitivity to Polatuzumab Vedotin in Diffuse Large B-Cell Lymphoma by Corcoran, Sean R, Phelan, James D, Choi, Jaewoo, Shevchenko, Galina, Fenner, Rachel E, Yu, Xin, Scheich, Sebastian, Hsiao, Tony, Morris, Vivian M, Papachristou, Evangelia K, Kishore, Kamal, D'Santos, Clive S, Ji, Yanlong, Pittaluga, Stefania, Wright, George W, Urlaub, Henning, Pan, Kuan-Ting, Oellerich, Thomas, Muppidi, Jagan, Hodson, Daniel J, Staudt, Louis M

“…Polatuzumab vedotin (Pola-V) is an antibody-drug conjugate directed to the CD79B subunit of the B-cell receptor (BCR). When combined with conventional…”
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Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response by Nagarajan, Sankari, Rao, Shalini V., Sutton, Joseph, Cheeseman, Danya, Dunn, Shanade, Papachristou, Evangelia K., Prada, Jose-Enrique Gonzalez, Couturier, Dominique-Laurent, Kumar, Sanjeev, Kishore, Kamal, Chilamakuri, Chandra Sekhar Reddy, Glont, Silvia-Elena, Goode, Emily Archer, Brodie, Cara, Guppy, Naomi, Natrajan, Rachael, Bruna, Alejandra, Caldas, Carlos, Russell, Alasdair, Siersbæk, Rasmus, Yusa, Kosuke, Chernukhin, Igor, Carroll, Jason S.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Erratum: Asparagine bioavailability governs metastasis in a model of breast cancer by Knott, Simon R. V., Wagenblast, Elvin, Khan, Showkhin, Kim, Sun Y., Soto, Mar, Wagner, Michel, Turgeon, Marc-Olivier, Fish, Lisa, Erard, Nicolas, Gable, Annika L., Maceli, Ashley R., Dickopf, Steffen, Papachristou, Evangelia K., D’Santos, Clive S., Carey, Lisa A., Wilkinson, John E., Harrell, J. Chuck, Perou, Charles M., Goodarzi, Hani, Poulogiannis, George, Hannon, Gregory J.

“…Nature 554, 378–381 (2018); doi:10.1038/nature25465 In this Letter, several errors were inadvertently introduced during the production process. In Fig. 3d, the…”
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