Search Results - "Paolucci, Mauro"

Establish an automated flow injection ESI-MS method for the screening of fragment based libraries: Application to Hsp90 by Riccardi Sirtori, Federico, Caronni, Dannica, Colombo, Maristella, Dalvit, Claudio, Paolucci, Mauro, Regazzoni, Luca, Visco, Carlo, Fogliatto, Gianpaolo

“…[Display omitted] ESI-MS is a well established technique for the study of biopolymers (nucleic acids, proteins) and their non covalent adducts, due to its…”
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NMS-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity against Multiple Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases by FOGLIATTO, Gianpaolo, GIANELLINI, Laura, PAOLUCCI, Mauro, POLUCCI, Paolo, RUSSO, Micaela, SOLA, Francesco, VALSASINA, Barbara, VISCO, Carlo, ZUCCOTTO, Fabio, DONATI, Daniele, FELDER, Eduard, PESENTI, Enrico, BRASCA, Maria G, GALVANI, Arturo, MANTEGANI, Sergio, ISACCHI, Antonella, CASALE, Elena, BALLINARI, Dario, CIOMEI, Marina, DEGRASSI, Anna, DE PONTI, Anna, GERMANI, Massimiliano, GUANCI, Marco

“…Recent developments of second generation Hsp90 inhibitors suggested a potential for development of this class of molecules also in tumors that have become…”
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Insights into PARP Inhibitors' Selectivity Using Fluorescence Polarization and Surface Plasmon Resonance Binding Assays by Papeo, Gianluca, Avanzi, Nilla, Bettoni, Serena, Leone, Antonella, Paolucci, Mauro, Perego, Rita, Quartieri, Francesca, Riccardi-Sirtori, Federico, Thieffine, Sandrine, Montagnoli, Alessia, Lupi, Rosita

“…PARP inhibitors are an exciting new class of antineoplastic drugs that have been proven to be efficacious as single agents in cancer settings with inherent DNA…”
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Abstract 691: In vitro and in vivo characterization of selective orally available Parp-1 inhibitors with demonstrated antitumor efficacy in BRCA negative cancer models by Papeo, Gianluca, Rainoldi, Sonia, Gianellini, Laura, Ciavolella, Antonella, Leone, Antonella, Lupi, Rosita, Sola, Francesco, Caprera, Francesco, Paolucci, Mauro, Thieffine, Sandrine, Perego, Rita, Albanese, Clara, Casale, Elena, Forte, Barbara, Guanci, Marco, Orsini, Paolo, Posteri, Helena, Scolaro, Alessandra, Riccardi-Sirtori, Federico, Zuccotto, Fabio, Donati, Daniele, Moll, Jurgen, Montagnoli, Alessia

“…Abstract Poly (ADP-ribose) polymerase 1 and 2 (Parp-1 and Parp-2) are nuclear enzymes responsible for signaling the presence of DNA damages by catalyzing the…”
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Abstract A213: Potent anticancer activity in vitro and in vivo by NMS-E973, a novel synthetic inhibitor of HSP90 by Fogliatto, Gianpaolo, Mantegani, Sergio, Amboldi, Nadia, Ballinari, Dario, Brasca, Maria Gabriella, Caprera, Francesco, Cappella, Paolo, Casale, Elena, De Ponti, Anna, Guanci, Marco, Paolucci, Mauro, Sola, Francesco, Valsasina, Barbara, Visco, Carlo, Zuccotto, Fabio, Colotta, Francesco, Felder, Eduard, Donati, Daniele, Moll, Juergen, Galvani, Arturo, Pesenti, Enrico, Isacchi, Antonella

“…Abstract The molecular chaperone heat shock protein 90 (HSP90) is essential for the conformational maturation and stability of a variety of proteins, including…”
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