Search Results - "Paoloni, Melissa"

Translation of new cancer treatments from pet dogs to humans by Khanna, Chand, Paoloni, Melissa

“…Naturally occurring cancers in pet dogs are similar to those in humans, and there is a growing interest in using studies in dogs to complement research in…”
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The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway by Gordon, Ira, Paoloni, Melissa, Mazcko, Christina, Khanna, Chand

“…Chand Khanna and colleagues describe the work of the Comparative Oncology Trials Consortium (COTC), which provides infrastructure and resources to integrate…”
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Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression by Paoloni, Melissa, Davis, Sean, Lana, Susan, Withrow, Stephen, Sangiorgi, Luca, Picci, Piero, Hewitt, Stephen, Triche, Timothy, Meltzer, Paul, Khanna, Chand

“…Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has…”
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Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs by Paoloni, Melissa C, Mazcko, Christina, Fox, Elizabeth, Fan, Timothy, Lana, Susan, Kisseberth, William, Vail, David M, Nuckolls, Kaylee, Osborne, Tanasa, Yalkowsy, Samuel, Gustafson, Daniel, Yu, Yunkai, Cao, Liang, Khanna, Chand

“…Signaling through the mTOR pathway contributes to growth, progression and chemoresistance of several cancers. Accordingly, inhibitors have been developed as…”
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Launching a Novel Preclinical Infrastructure: Comparative Oncology Trials Consortium Directed Therapeutic Targeting of TNFα to Cancer Vasculature by Paoloni, Melissa C., Tandle, Anita, Mazcko, Christina, Hanna, Engy, Kachala, Stefan, LeBlanc, Amy, Newman, Shelley, Vail, David, Henry, Carolyn, Thamm, Douglas, Sorenmo, Karin, Hajitou, Amin, Pasqualini, Renata, Arap, Wadih, Khanna, Chand, Libutti, Steven K.

“…Background Under the direction and sponsorship of the National Cancer Institute, we report on the first pre-clinical trial of the Comparative Oncology Trials…”
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Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer by Dhawan, Deepika, Paoloni, Melissa, Shukradas, Shweta, Choudhury, Dipanwita Roy, Craig, Bruce A, Ramos-Vara, José A, Hahn, Noah, Bonney, Patty L, Khanna, Chand, Knapp, Deborah W

“…More than 160,000 people are expected to die from invasive urothelial carcinoma (iUC) this year worldwide. Research in relevant animal models is essential to…”
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NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma by Burton, Jenna H, Mazcko, Christina, LeBlanc, Amy, Covey, Joseph M, Ji, Jiuping, Kinders, Robert J, Parchment, Ralph E, Khanna, Chand, Paoloni, Melissa, Lana, Sue, Weishaar, Kristen, London, Cheryl, Kisseberth, William, Krick, Erika, Vail, David, Childress, Michael, Bryan, Jeffrey N, Barber, Lisa, Ehrhart, E J, Kent, Michael, Fan, Timothy, Kow, Kelvin, Northup, Nicole, Wilson-Robles, Heather, Tomaszewski, Joseph, Holleran, Julianne L, Muzzio, Miguel, Eiseman, Julie, Beumer, Jan H, Doroshow, James H, Pommier, Yves

“…Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because of their…”
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Comparative oncology today by Paoloni, Melissa C, Khanna, Chand

“…The value of comparative oncology has been increasingly recognized in the field of cancer research, including the identification of cancer-associated genes;…”
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Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma by Paoloni, Melissa, Mazcko, Christina, Selting, Kimberly, Lana, Susan, Barber, Lisa, Phillips, Jeffrey, Skorupski, Katherine, Vail, David, Wilson, Heather, Biller, Barbara, Avery, Anne, Kiupel, Matti, LeBlanc, Amy, Bernhardt, Anna, Brunkhorst, Beatrice, Tighe, Robert, Khanna, Chand

“…Interleukin (IL)-12 is a pro-inflammatory cytokine that mediates T-helper type 1 responses and cytotoxic T-cell activation, contributing to its utility as…”
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A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model by Saba, Corey, Paoloni, Melissa, Mazcko, Christina, Kisseberth, William, Burton, Jenna H, Smith, Annette, Wilson-Robles, Heather, Allstadt, Sara, Vail, David, Henry, Carolyn, Lana, Susan, Ehrhart, E J, Charles, Brad, Kent, Michael, Lawrence, Jessica, Burgess, Kristine, Borgatti, Antonella, Suter, Steve, Woods, Paul, Gordon, Ira, Vrignaud, Patricia, Khanna, Chand, LeBlanc, Amy K

“…Development of iniparib as an anti-cancer agent was hindered in part by lingering questions regarding its mechanism of action, the activity of its metabolites,…”
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Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials by Paoloni, Melissa, Webb, Craig, Mazcko, Christina, Cherba, David, Hendricks, William, Lana, Susan, Ehrhart, E J, Charles, Brad, Fehling, Heather, Kumar, Leena, Vail, David, Henson, Michael, Childress, Michael, Kitchell, Barbara, Kingsley, Christopher, Kim, Seungchan, Neff, Mark, Davis, Barbara, Khanna, Chand, Trent, Jeffrey

“…Molecularly-guided trials (i.e. PMed) now seek to aid clinical decision-making by matching cancer targets with therapeutic options. Progress has been hampered…”
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A compendium of canine normal tissue gene expression by Briggs, Joseph, Paoloni, Melissa, Chen, Qing-Rong, Wen, Xinyu, Khan, Javed, Khanna, Chand

“…Our understanding of disease is increasingly informed by changes in gene expression between normal and abnormal tissues. The release of the canine genome…”
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COMPUTED TOMOGRAPHY CHARACTERISTICS OF CANINE TRACHEOBRONCHIAL LYMPH NODE METASTASIS by BALLEGEER, ELIZABETH A, ADAMS, WILLIAM M, DUBIELZIG, RICHARD R, PAOLONI, MELISSA C, KLAUER, JULIA M, KEULER, NICHOLAS S

“…Tracheobronchial lymph node evaluation is critical for accurate staging of canine thoracic neoplasia and is more accurately achieved with computed tomography…”
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Science and society: Translation of new cancer treatments from pet dogs to humans by Paoloni, Melissa, Khanna, Chand, S

“…Naturally occurring cancers in pet dogs and humans share many features, including histological appearance, tumour genetics, molecular targets, biological…”
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Comparison of results of computed tomography and radiography with histopathologic findings in tracheobronchial lymph nodes in dogs with primary lung tumors: 14 cases (1999-2002). [Erratum: 2006 Sept. 1, v. 229, no. 5, p. 710.] by Paoloni, M.C, Adams, W.M, Dubielzig, R.R, Kurzman, I, Vail, D.M, Hardie, R.J

“…Objective-To compare results of computed tomography (CT) and radiography with histopathologic findings in tracheobronchial lymph nodes (TBLNs) in dogs with…”
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ULTRASONOGRAPHIC AND CLINICOPATHOLOGIC FINDINGS IN 21 DOGS WITH INTESTINAL ADENOCARCINOMA by Paoloni, Melissa C., Penninck, Dominique G., Moore, Antony S.

“…In a retrospective study of 21 dogs with intestinal adenocarcinoma, the signalment, clinical presentation, laboratory findings, ultrasonographic features,…”
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Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients by Yau, Christina, van der Noordaa, Marieke, Shad, Sonal, de Croze, Diane, Hamy, Anne-Sophie, Laé, Marick, Reyal, Fabien, Sonke, Gabe S, Steenbruggen, Tessa G, van Seijen, Maartje, Wesseling, Jelle, del Monte-Millán, Maria, López-Tarruella, Sara, Albain, Kathy S., Asare, Smita M., Balassanian, Ron, Beckwith, Heather, Berry, Scott M., Berry, Donald A., Boughey, Judy C., Buxton, Meredith B., Chen, Yunn-Yi, Chen, Beiyun, Clark, Amy S., Clennell, Julia L., DeMichele, Angela M., Duan, Xiuzhen, Edmiston, Kirsten K., Ellis, Erin D., Esserman, Laura L., Euhus, David M., Fan, Fang, Feldman, Michael D, Han, Hyo S., Haugen, Patricia, Helsten, Teresa, Hylton, Nola M., Isaacs, Claudine, Kemmer, Kathleen, Khazai, Laila, Klein, Molly E., Krings, Gregor, Leyland-Jones, Brian, Liu, Minetta C., Lo, Shelly, Lu, Janice, Magliocco, Anthony, Melisko, Michelle E., Mhawech-Fauceglia, Paulette, Moulder, Stacy L., Murthy, Rashmi K., Nanda, Rita, Ocal, Idris T., Olopade, Olufunmilayo, Pambuccian, Stefan, Paoloni, Melissa, Park, John W., Perlmutter, Jane, Peterson, Garry, Rendi, Mara, Rugo, Hope S., Sams, Sharon, Sattar, Husain, Schwab, Richard B., Singhrao, Ruby, Steeg, Katherine, Stringer-Reasor, Erica, Symmans, W. Fraser, Tripathy, Debasish, Troxell, Megan L., van't Veer, Laura J., Venters, Sara J., Vinh, Tuyethoa, Viscusi, Rebecca K., Wallace, Anne M., Wei, Shi, Wilson, Amy, Yau, Christina, Zeck, Jay C., Boughey, Judy C, Goetz, Matthew P, Hoskin, Tanya, Gould, Rebekah, Edge, Stephen B, Abraham, Jean E, Bartlett, John M S, Caldas, Carlos, Dunn, Janet, Hayward, Larry, Provenzano, Elena, Mackintosh, Lorna, Fan, Fang, Schwensen, Kelsey, Sharma, Priyanka, DeMichele, Angela M, Cole, Kimberly, Pusztai, Lajos, Kim, Mi-Ok, van 't Veer, Laura J, Symmans, W Fraser

“…Previous studies have independently validated the prognostic relevance of residual cancer burden (RCB) after neoadjuvant chemotherapy. We used results from…”
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Adaptive platform trials: definition, design, conduct and reporting considerations by Angus, Derek C, Alexander, Brian M, Berry, Scott, Buxton, Meredith, Lewis, Roger, Paoloni, Melissa, Webb, Steven A. R, Arnold, Steven, Barker, Anna, Berry, Donald A, Bonten, Marc J. M, Brophy, Mary, Butler, Christopher, Cloughesy, Timothy F, Derde, Lennie P. G, Esserman, Laura J, Ferguson, Ryan, Fiore, Louis, Gaffey, Sarah C, Gaziano, J. Michael, Giusti, Kathy, Goossens, Herman, Heritier, Stephane, Hyman, Bradley, Krams, Michael, Larholt, Kay, LaVange, Lisa M, Lavori, Philip, Lo, Andrew W, London, Alex John, Manax, Victoria, McArthur, Colin, O'Neill, Genevieve, Parmigiani, Giovanni, Perlmutter, Jane, Petzold, Elizabeth A, Ritchie, Craig, Rowan, Kathryn M, Seymour, Christopher W, Shapiro, Nathan I, Simeone, Diane M, Smith, Bradley, Spellberg, Bradley, Stern, Ariel Dora, Trippa, Lorenzo, Trusheim, Mark, Viele, Kert, Wen, Patrick Y, Woodcock, Janet

“…Researchers, clinicians, policymakers and patients are increasingly interested in questions about therapeutic interventions that are difficult or costly to…”
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Adaptive Randomization of Veliparib–Carboplatin Treatment in Breast Cancer by Rugo, Hope S, Olopade, Olufunmilayo I, DeMichele, Angela, Yau, Christina, van ’t Veer, Laura J, Buxton, Meredith B, Hogarth, Michael, Hylton, Nola M, Paoloni, Melissa, Perlmutter, Jane, Symmans, W. Fraser, Yee, Douglas, Chien, A. Jo, Wallace, Anne M, Kaplan, Henry G, Boughey, Judy C, Haddad, Tufia C, Albain, Kathy S, Liu, Minetta C, Isaacs, Claudine, Khan, Qamar J, Lang, Julie E, Viscusi, Rebecca K, Pusztai, Lajos, Moulder, Stacy L, Chui, Stephen Y, Kemmer, Kathleen A, Elias, Anthony D, Edmiston, Kirsten K, Euhus, David M, Haley, Barbara B, Nanda, Rita, Northfelt, Donald W, Tripathy, Debasish, Wood, William C, Ewing, Cheryl, Schwab, Richard, Lyandres, Julia, Davis, Sarah E, Hirst, Gillian L, Sanil, Ashish, Berry, Donald A, Esserman, Laura J

“…Using an adaptive trial design to minimize the exposure of patients to inactive agents and to detect more active regimens sooner, investigators found that…”
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Adaptive Randomization of Neratinib in Early Breast Cancer by Park, John W, Liu, Minetta C, Yee, Douglas, Yau, Christina, van ’t Veer, Laura J, Symmans, W. Fraser, Paoloni, Melissa, Perlmutter, Jane, Hylton, Nola M, Hogarth, Michael, DeMichele, Angela, Buxton, Meredith B, Chien, A. Jo, Wallace, Anne M, Boughey, Judy C, Haddad, Tufia C, Chui, Stephen Y, Kemmer, Kathleen A, Kaplan, Henry G, Isaacs, Claudine, Nanda, Rita, Tripathy, Debasish, Albain, Kathy S, Edmiston, Kirsten K, Elias, Anthony D, Northfelt, Donald W, Pusztai, Lajos, Moulder, Stacy L, Lang, Julie E, Viscusi, Rebecca K, Euhus, David M, Haley, Barbara B, Khan, Qamar J, Wood, William C, Melisko, Michelle, Schwab, Richard, Helsten, Teresa, Lyandres, Julia, Davis, Sarah E, Hirst, Gillian L, Sanil, Ashish, Esserman, Laura J, Berry, Donald A

“…Among patients with HER2-positive, hormone-receptor–negative locally advanced breast cancer, the addition of neratinib to standard therapy resulted in higher…”
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