Search Results - "Paolo, Therese Di"

Metabotropic glutamate receptors as therapeutic targets in Parkinson's disease: An update from the last 5 years of research by Litim, Nadhir, Morissette, Marc, Di Paolo, Thérèse

“…Disturbance of glutamate neurotransmission in Parkinson's disease (PD) and l-DOPA induced dyskinesia (LID) is well documented. This review focuses on advances…”
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Raloxifene activates G protein-coupled estrogen receptor 1/Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice by Bourque, Mélanie, Morissette, Marc, Di Paolo, Thérèse

“…Abstract Raloxifene, used in the clinic, is reported to protect brain dopaminergic neurons in mice. Raloxifene was shown to mediate an effect through the G…”
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Neuroprotective actions of sex steroids in Parkinson’s disease by Bourque, Mélanie, Dluzen, Dean E, Di Paolo, Thérèse

“…Abstract The sex difference in Parkinson’s disease, with a higher susceptibility in men, suggests a modulatory effect of sex steroids in the brain. Numerous…”
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Gastrointestinal Dysfunctions in Parkinson's Disease: Symptoms and Treatments by Di Paolo, Thérèse, Morin, Nicolas, Côté, Mélissa, Aubé, Benoit, Poirier, Andrée-Anne, Soulet, Denis

“…A diagnosis of Parkinson’s disease is classically established after the manifestation of motor symptoms such as rigidity, bradykinesia, and tremor. However, a…”
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Neuroprotective and immunomodulatory effects of raloxifene in the myenteric Plexus of a mouse model of Parkinson’s disease by Poirier, Andrée-Anne, Côté, Mélissa, Bourque, Mélanie, Morissette, Marc, Di Paolo, Thérèse, Soulet, Denis

“…Abstract Motor symptoms in Parkinson’s disease (PD) are often preceded by non-motor symptoms related to dysfunctions of the autonomic nervous system such as…”
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Neuroprotection and immunomodulation of progesterone in the gut of a mouse model of Parkinson's disease by Jarras, Hend, Bourque, Mélanie, Poirier, Andrée‐Anne, Morissette, Marc, Coulombe, Katherine, Di Paolo, Thérèse, Soulet, Denis

“…Gastrointestinal symptoms appear in Parkinson's disease patients many years before motor symptoms, suggesting the implication of dopaminergic neurones of the…”
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Plasmalogen Augmentation Reverses Striatal Dopamine Loss in MPTP Mice by Miville-Godbout, Edith, Bourque, Mélanie, Morissette, Marc, Al-Sweidi, Sara, Smith, Tara, Mochizuki, Asuka, Senanayake, Vijitha, Jayasinghe, Dushmanthi, Wang, Li, Goodenowe, Dayan, Di Paolo, Thérèse

“…Plasmalogens are a class of glycerophospholipids shown to play critical roles in membrane structure and function. Decreased plasmalogens are reported in the…”
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The number of striatal cholinergic interneurons expressing calretinin is increased in parkinsonian monkeys by Petryszyn, Sarah, Di Paolo, Thérèse, Parent, André, Parent, Martin

“…Abstract The most abundant interneurons in the primate striatum are those expressing the calcium-binding protein calretinin (CR). The present…”
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Three-Dimensional Analysis of Sex- and Gonadal Status- Dependent Microglial Activation in a Mouse Model of Parkinson's Disease by Isenbrandt, Amandine, Coulombe, Katherine, Morissette, Marc, Bourque, Mélanie, Lamontagne-Proulx, Jérôme, Di Paolo, Thérèse, Soulet, Denis

“…Parkinson's disease (PD) is characterized by neurodegeneration and neuroinflammation. PD prevalence and incidence are higher in men than in women and…”
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Sex and Age Differences in a Progressive Synucleinopathy Mouse Model by Lamontagne-Proulx, Jérôme, Coulombe, Katherine, Morissette, Marc, Rieux, Marie, Calon, Frédéric, Di Paolo, Thérèse, Soulet, Denis

“…The mutation and overexpression of the alpha-synuclein protein (αSyn), described as synucleinopathy, is associated with Parkinson's disease (PD)-like…”
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GPER1-mediated immunomodulation and neuroprotection in the myenteric plexus of a mouse model of Parkinson's disease by Côté, Mélissa, Bourque, Mélanie, Poirier, Andrée-Anne, Aubé, Benoit, Morissette, Marc, Di Paolo, Thérèse, Soulet, Denis

“…Abstract Lewy pathology affects the gastrointestinal tract in Parkinson's disease (PD) and recent reports suggest a link between the disorder and gut…”
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Implication of GPER1 in neuroprotection in a mouse model of Parkinson's disease by Bourque, Mélanie, Morissette, Marc, Côté, Mélissa, Soulet, Denis, Di Paolo, Thérèse

“…Abstract This study investigated the contribution of the new G protein-coupled estrogen receptor 1 (GPER1) in neuroprotection by 17β-estradiol in the…”
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Evidence for Sprouting of Dopamine and Serotonin Axons in the Pallidum of Parkinsonian Monkeys by Gagnon, Dave, Eid, Lara, Coudé, Dymka, Whissel, Carl, Di Paolo, Thérèse, Parent, André, Parent, Martin

“…This light and electron microscopie immunohistochemical quantitative study aimed at determining the state of the dopamine (DA) and serotonin (5-HT)…”
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Steroids‐Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders by Sánchez, Maria Gabriela, Bourque, Mélanie, Morissette, Marc, Di Paolo, Thérèse

“…SUMMARY Introduction: Dopamine cell loss is well documented in Parkinson's disease and dopamine hypofunction is proposed in certain depressive states. At the…”
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Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice by Bourque, Mélanie, Morissette, Marc, Al Sweidi, Sara, Caruso, Donatella, Melcangi, Roberto C, Di Paolo, Thérèse

“…Numerous studies have reported on the neuroprotective activity of estradiol, whereas the effect of the other ovarian steroid, progesterone, is much less…”
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Long-term treatment with l-DOPA and an mGlu5 receptor antagonist prevents changes in brain basal ganglia dopamine receptors, their associated signaling proteins and neuropeptides in parkinsonian monkeys by Morin, Nicolas, Jourdain, Vincent A., Morissette, Marc, Grégoire, Laurent, Di Paolo, Thérèse

“…Brain glutamate overactivity is well documented in Parkinson's disease (PD) and antiglutamatergic drugs decrease L-3,4-dihydroxyphenylalanine (l-DOPA)-induced…”
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Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson's Disease Models by Poirier, Andrée-Anne, Côté, Mélissa, Jarras, Hend, Litim, Nadhir, Lamontagne-Proulx, Jérôme, Al-Sweidi, Sara, Morissette, Marc, Lachhab, Asmaa, Pelletier, Martin, Di Paolo, Thérèse, Soulet, Denis

“…Gastrointestinal disorders in Parkinson's disease (PD) have been associated with neuronal alteration in the plexus of the gut. We previously demonstrated the…”
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Metabotropic Glutamate Receptors for Parkinson's Disease Therapy by Gasparini, Fabrizio, Gomez-Mancilla, Baltazar, Di Paolo, Thérèse

“…Excessive glutamatergic signalling within the basal ganglia is implicated in the progression of Parkinson’s disease (PD) and inthe emergence of dyskinesia…”
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Prevention of L-Dopa-Induced Dyskinesias by MPEP Blockade of Metabotropic Glutamate Receptor 5 Is Associated with Reduced Inflammation in the Brain of Parkinsonian Monkeys by Morissette, Marc, Bourque, Mélanie, Tremblay, Marie-Ève, Di Paolo, Thérèse

“…Proinflammatory markers were found in brains of Parkinson's disease (PD) patients. After years of L-Dopa symptomatic treatment, most PD patients develop…”
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Sex differences in methamphetamine toxicity in mice: Effect on brain dopamine signaling pathways by Bourque, Mélanie, Liu, Bin, Dluzen, Dean E, Di Paolo, Thérèse

“…Summary Male mice were reported to display greater methamphetamine-induced neurotoxicity than females. The present study evaluated the involvement of…”
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