Search Results - "Paolillo, Joshua M."
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Anaerobic Hydroxylation of C(sp3)–H Bonds Enabled by the Synergistic Nature of Photoexcited Nitroarenes
Published in Journal of the American Chemical Society (08-02-2023)“…A photoexcited-nitroarene-mediated anaerobic C–H hydroxylation of aliphatic systems is reported. The success of this reaction is due to the bifunctional nature…”
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Photoinduced Oxygen Transfer Using Nitroarenes for the Anaerobic Cleavage of Alkenes
Published in Journal of the American Chemical Society (31-08-2022)“…Herein we report the anaerobic cleavage of alkenes into carbonyl compounds using nitroarenes as oxygen transfer reagents under visible light. This approach…”
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Oxidative Amidation of Amines in Tandem with Transamidation: A Route to Amides Using Visible-Light Energy
Published in Journal of organic chemistry (17-07-2020)“…A methodology is reported for preparing amides using amines as an acyl source. The protocol involves the visible-light-promoted oxidative amidation of amines…”
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Scalable copper‐catalyzed preparation of imidazopyridinones from iodopyridinyl ureas
Published in Journal of heterocyclic chemistry (01-02-2023)“…The efficient copper‐catalyzed construction of imidazopyridinones is described. Beginning from iodopyridinyl ureas, Ullmann coupling provides…”
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Development of a Scalable Synthesis toward a KRAS G12C Inhibitor Building Block Bearing an All-Carbon Quaternary Stereocenter, Part 2: Asymmetric Synthesis via Shi Epoxidation
Published in Organic process research & development (19-01-2024)“…The development of a scalable asymmetric synthesis of KRAS G12C inhibitor building block 1 is described. The all-carbon quaternary stereocenter was installed…”
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