Search Results - "Paolello, Mitchell"

Kinetic Optimization of the Batch Crystallization of an Active Pharmaceutical Ingredient in the Presence of a Low-Solubility, Precipitating Impurity by Paolello, Mitchell, Bichari, Ilyes, Brouckaert, Davinia, Francis, Mirvatte, Yang, Dawn, Capellades, Gerard

“…The presence of impurities above regulatory thresholds has been responsible for recent recalls of pharmaceutical drugs. Crystallization is one of the most used…”
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Thermodynamic Stability Transitions and Coexistence of Two Polymorphs via Crystalline Solid Solutions: The T‑X Phase Diagram of Salicylic Acid and 2,3-Dihydroxybenzoic Acid by Mohajerani, Seyed Sepehr, Paolello, Mitchell, Linehan, Brian, Ricci, Francesco, Capellades, Gerard, Nordstrom, Fredrik L.

“…The thermodynamically stable phases of salicylic acid (SA) and 2,3-dihydroxybenzoic acid (23DHBA) have been determined experimentally in a T-X phase diagram…”
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Polymorphic Stability Shifts, Co-Crystals, and Crystalline Solid Solutions: The T‑X Phase Diagram of Salicylic Acid–Salicylamide by Paolello, Mitchell, Mohajerani, Seyed Sepehr, Linehan, Brian, Ricci, Francesco, Capellades, Gerard, Nordstrom, Fredrik L.

“…The thermodynamic phases of salicylic acid (SA) and salicylamide (SM) and their respective domains in a T-X diagram were determined experimentally from 25 °C…”
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Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations by Nordstrom, Fredrik L., Sirota, Eric, Hartmanshenn, Clara, Kwok, Thomas T., Paolello, Mitchell, Li, Huayu, Abeyta, Vincent, Bramante, Tommasina, Madrigal, Emma, Behre, Taylor, Capellades, Gerard

“…The rejection of process impurities from crystallizing products is an essential step for the purification of pharmaceutical drugs and for the isolation of…”
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Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization. Part 1: Theoretical Basis and Workflow for Efficient Impurity Rejection by Nordstrom, Fredrik L., Paolello, Mitchell, Yao, Na, Armiger, Travis, Jiang, Qi, Nicholson, James, Kratz, Joseph, Toresco, Michael, Lipp, Alexander, Witte, Swjatoslaw, Henry, Manuel, Shultz, C. Scott, Sirota, Eric, Capellades, Gerard

“…Crystallization is routinely employed in industrial chemical synthesis to remove undesired impurities and obtain the product as a crystalline solid. A common…”
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Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization – Part 2: Industrial Case Studies by Nordstrom, Fredrik L., Paolello, Mitchell, Yao, Na, Armiger, Travis, Jiang, Qi, Nicholson, James, Kratz, Joseph, Toresco, Michael, Lipp, Alexander, Witte, Swjatoslaw, Henry, Manuel, Shultz, C. Scott, Sirota, Eric, Capellades, Gerard

“…Three industrial case studies are presented from the pharmaceutical companies Boehringer-Ingelheim and Merck & Co., Inc. (Rahway, NJ) demonstrating how…”
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