Search Results - "Paolella, Brenton R."

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action by McFarland, James M., Paolella, Brenton R., Warren, Allison, Geiger-Schuller, Kathryn, Shibue, Tsukasa, Rothberg, Michael, Kuksenko, Olena, Colgan, William N., Jones, Andrew, Chambers, Emily, Dionne, Danielle, Bender, Samantha, Wolpin, Brian M., Ghandi, Mahmoud, Tirosh, Itay, Rozenblatt-Rosen, Orit, Roth, Jennifer A., Golub, Todd R., Regev, Aviv, Aguirre, Andrew J., Vazquez, Francisca, Tsherniak, Aviad

“…Assays to study cancer cell responses to pharmacologic or genetic perturbations are typically restricted to using simple phenotypic readouts such as…”
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Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities by Nichols, Caitlin A., Gibson, William J., Brown, Meredith S., Kosmicki, Jack A., Busanovich, John P., Wei, Hope, Urbanski, Laura M., Curimjee, Naomi, Berger, Ashton C., Gao, Galen F., Cherniack, Andrew D., Dhe-Paganon, Sirano, Paolella, Brenton R., Beroukhim, Rameen

“…Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss…”
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Systematic profiling of conditional degron tag technologies for target validation studies by Bondeson, Daniel P., Mullin-Bernstein, Zachary, Oliver, Sydney, Skipper, Thomas A., Atack, Thomas C., Bick, Nolan, Ching, Meilani, Guirguis, Andrew A., Kwon, Jason, Langan, Carly, Millson, Dylan, Paolella, Brenton R., Tran, Kevin, Wie, Sarah J., Vazquez, Francisca, Tothova, Zuzana, Golub, Todd R., Sellers, William R., Ianari, Alessandra

“…Conditional degron tags (CDTs) are a powerful tool for target validation that combines the kinetics and reversible action of pharmacological agents with the…”
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Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal by Krill-Burger, J. Michael, Dempster, Joshua M., Borah, Ashir A., Paolella, Brenton R., Root, David E., Golub, Todd R., Boehm, Jesse S., Hahn, William C., McFarland, James M., Vazquez, Francisca, Tsherniak, Aviad

“…Abstract Background Hundreds of functional genomic screens have been performed across a diverse set of cancer contexts, as part of efforts such as the Cancer…”
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Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells by Sullivan, Jaclyn M., Havrda, Matthew C., Kettenbach, Arminja N., Paolella, Brenton R., Zhang, Zhonghua, Gerber, Scott A., Israel, Mark A.

“…Inhibitor of DNA binding proteins (Id1‐Id4) function to inhibit differentiation and promote proliferation of many different cell types. Among the Id family…”
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Id2 Is Required for Specification of Dopaminergic Neurons during Adult Olfactory Neurogenesis by Havrda, Matthew C, Harris, Brent T, Mantani, Akio, Ward, Nora M, Paolella, Brenton R, Cuzon, Verginia C, Yeh, Hermes H, Israel, Mark A

“…Understanding the biology of adult neural stem cells has important implications for nervous system development and may contribute to our understanding of…”
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Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice by Havrda, Matthew C, Paolella, Brenton R, Ward, Nora M, Holroyd, Kathryn B

“…Characterizing dopaminergic neuronal development and function in novel genetic animal models might uncover strategies for researchers to develop…”
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Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers by Ito, Takahiro, Young, Michael J., Li, Ruitong, Jain, Sidharth, Wernitznig, Andreas, Krill-Burger, John M., Lemke, Christopher T., Monducci, Davide, Rodriguez, Diego J., Chang, Liang, Dutta, Sanjukta, Pal, Debjani, Paolella, Brenton R., Rothberg, Michael V., Root, David E., Johannessen, Cory M., Parida, Laxmi, Getz, Gad, Vazquez, Francisca, Doench, John G., Zamanighomi, Mahdi, Sellers, William R.

“…Although single-gene perturbation screens have revealed a number of new targets, vulnerabilities specific to frequently altered drivers have not been…”
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A first-generation pediatric cancer dependency map by Dharia, Neekesh V., Kugener, Guillaume, Guenther, Lillian M., Malone, Clare F., Durbin, Adam D., Hong, Andrew L., Howard, Thomas P., Bandopadhayay, Pratiti, Wechsler, Caroline S., Fung, Iris, Warren, Allison C., Dempster, Joshua M., Krill-Burger, John M., Paolella, Brenton R., Moh, Phoebe, Jha, Nishant, Tang, Andrew, Montgomery, Philip, Boehm, Jesse S., Hahn, William C., Roberts, Charles W. M., McFarland, James M., Tsherniak, Aviad, Golub, Todd R., Vazquez, Francisca, Stegmaier, Kimberly

“…Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional…”
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BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma by BANDOPADHAYAY, Pratiti, BERGTHOLD, Guillaume, FURONG YU, NUJSAUBNUSI VUE, GIBSON, William J, PAOLELLA, Brenton R, MITRA, Siddhartha S, CHESHIER, Samuel H, JUN QI, LIU, Kun-Wei, WECHSLER-REYA, Robert, WEISS, William A, NGUYEN, Brian, SWARTLING, Fredrik J, KIERAN, Mark W, BRADNER, James E, BEROUKHIM, Rameen, CHO, Yoon-Jae, SCHUBERT, Simone, GHOLAMIN, Sharareh, YUJIE TANG, BOLIN, Sara, SCHUMACHER, Steven E, ZEID, Rhamy, MASOUD, Sabran

“…MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and extraterminal (BET) bromodomain inhibition has recently been shown to suppress…”
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Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells by Reitman, Zachary J., Paolella, Brenton R., Bergthold, Guillaume, Pelton, Kristine, Becker, Sarah, Jones, Robert, Sinai, Claire E., Malkin, Hayley, Huang, Ying, Grimmet, Leslie, Herbert, Zachary T., Sun, Yu, Weatherbee, Jessica L., Alberta, John A., Daley, John F., Rozenblatt-Rosen, Orit, Condurat, Alexandra L., Qian, Kenin, Khadka, Prasidda, Segal, Rosalind A., Haas-Kogan, Daphne, Filbin, Mariella G., Suva, Mario L., Regev, Aviv, Stiles, Charles D., Kieran, Mark W., Goumnerova, Liliana, Ligon, Keith L., Shalek, Alex K., Bandopadhayay, Pratiti, Beroukhim, Rameen

“…Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in…”
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Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer by Malone, Clare F, Dharia, Neekesh V, Kugener, Guillaume, Forman, Alexandra B, Rothberg, Michael V, Abdusamad, Mai, Gonzalez, Alfredo, Kuljanin, Miljan, Robichaud, Amanda L, Conway, Amy Saur, Dempster, Joshua M, Paolella, Brenton R, Dumont, Nancy, Hovestadt, Volker, Mancias, Joseph D, Younger, Scott T, Root, David E, Golub, Todd R, Vazquez, Francisca, Stegmaier, Kimberly

“…Cancer dependency maps, which use CRISPR/Cas9 depletion screens to profile the landscape of genetic dependencies in hundreds of cancer cell lines, have…”
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Gliomas “Dope Up” for Growth by Paolella, Brenton R., Stiles, Charles D.

“…An emerging body of data highlights trophic functions of neurotransmitters on proliferation and differentiation of normal neural progenitors. In this issue of…”
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Targeting Cancer Gene Dependencies with Anthrax-Mediated Delivery of Peptide Nucleic Acids by Lu, Zeyu, Paolella, Brenton R, Truex, Nicholas L, Loftis, Alexander R, Liao, Xiaoli, Rabideau, Amy E, Brown, Meredith S, Busanovich, John, Beroukhim, Rameen, Pentelute, Bradley L

“…Antisense oligonucleotide therapies are important cancer treatments, which can suppress genes in cancer cells that are critical for cell survival. has recently…”
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Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q by Neggers, Jasper E., Paolella, Brenton R., Asfaw, Adhana, Rothberg, Michael V., Skipper, Thomas A., Yang, Annan, Kalekar, Radha L., Krill-Burger, John M., Dharia, Neekesh V., Kugener, Guillaume, Kalfon, Jérémie, Yuan, Chen, Dumont, Nancy, Gonzalez, Alfredo, Abdusamad, Mai, Li, Yvonne Y., Spurr, Liam F., Wu, Westley W., Durbin, Adam D., Wolpin, Brian M., Piccioni, Federica, Root, David E., Boehm, Jesse S., Cherniack, Andrew D., Tsherniak, Aviad, Hong, Andrew L., Hahn, William C., Stegmaier, Kimberly, Golub, Todd R., Vazquez, Francisca, Aguirre, Andrew J.

“…Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new…”
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Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability by Paolella, Brenton R, Gibson, William J, Urbanski, Laura M, Alberta, John A, Zack, Travis I, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara A, Root, David E, Cowley, Glenn S, Buhrlage, Sara J, Stiles, Charles D, Ebert, Benjamin L, Hahn, William C, Reed, Robin, Beroukhim, Rameen

“…Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in…”
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Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer by Bondeson, Daniel P, Paolella, Brenton R, Asfaw, Adhana, Rothberg, Michael V, Skipper, Thomas A, Langan, Carly, Mesa, Gabriel, Gonzalez, Alfredo, Surface, Lauren E, Ito, Kentaro, Kazachkova, Mariya, Colgan, William N, Warren, Allison, Dempster, Joshua M, Krill-Burger, John M, Ericsson, Maria, Tang, Andrew A, Fung, Iris, Chambers, Emily S, Abdusamad, Mai, Dumont, Nancy, Doench, John G, Piccioni, Federica, Root, David E, Boehm, Jesse, Hahn, William C, Mannstadt, Michael, McFarland, James M, Vazquez, Francisca, Golub, Todd R

“…Despite advances in precision medicine, the clinical prospects for patients with ovarian and uterine cancers have not substantially improved. Here, we analyzed…”
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Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype by Bergthold, Guillaume, Bandopadhayay, Pratiti, Hoshida, Yujin, Ramkissoon, Shakti, Ramkissoon, Lori, Rich, Benjamin, Maire, Cecile L, Paolella, Brenton R, Schumacher, Steven E, Tabak, Barbara, Ferrer-Luna, Ruben, Ozek, Memet, Sav, Aydin, Santagata, Sandro, Wen, Patrick Yung, Goumnerova, Liliana C, Ligon, Azra H, Stiles, Charles, Segal, Rosalind, Golub, Todd, Grill, Jacques, Ligon, Keith L, Chan, Jennifer A, Kieran, Mark W, Beroukhim, Rameen

“…Pediatric low-grade gliomas (PLGGs), the most frequent pediatric brain tumor, comprise a heterogeneous group of diseases. Recent genomic analyses suggest that…”
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Id2 Mediates Oligodendrocyte Precursor Cell Maturation Arrest and Is Tumorigenic in a PDGF-Rich Microenvironment by HAVRDA, Matthew C, PAOLELLA, Brenton R, CONG RAN, JERING, Karola S, WRAY, Christina M, SULLIVAN, Jaclyn M, NAILOR, Audrey, HITOSHI, Yasuyuki, ISRAEL, Mark A

“…Maturation defects occurring in adult tissue progenitor cells have the potential to contribute to tumor development; however, there is little experimental…”
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p53 Directly Represses Id2 to Inhibit the Proliferation of Neural Progenitor Cells by Paolella, Brenton R., Havrda, Matthew C., Mantani, Akio, Wray, Christina M., Zhang, Zhonghua, Israel, Mark A.

“…Neural progenitor cells (NPCs) have the capacity to proliferate and give rise to all major central nervous system cell types and represent a possible cell of…”
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