Search Results - "Panzenbeck, Mark"

Deep learning for discovering pathological continuum of crypts and evaluating therapeutic effects: An implication for in vivo preclinical study by Shan, Dechao, Zheng, Jie, Klimowicz, Alexander, Panzenbeck, Mark, Liu, Zheng, Feng, Di

“…Applying deep learning to the field of preclinical in vivo studies is a new and exciting prospect with the potential to unlock decades worth of underutilized…”
Get full text

An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients by Bassolas-Molina, Helena, Raymond, Ernest, Labadia, Mark, Wahle, Joseph, Ferrer-Picón, Elena, Panzenbeck, Mark, Zheng, Jie, Harcken, Christian, Hughes, Robert, Turner, Michael, Smith, Dustin, Calderón-Gómez, Elisabeth, Esteller, Míriam, Carrasco, Anna, Esteve, Maria, Dotti, Isabella, Corraliza, Ana Maria, Masamunt, Maria Carme, Arajol, Clàudia, Guardiola, Jordi, Ricart, Elena, Nabozny, Gerald, Salas, Azucena

“…Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study…”
Get full text

Nonsteroidal Dissociated Glucocorticoid Agonists Containing Azaindoles as Steroid A-Ring Mimetics by Riether, Doris, Harcken, Christian, Razavi, Hossein, Kuzmich, Daniel, Gilmore, Thomas, Bentzien, Jörg, Pack, Edward J, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra, Tazmeen N, Zuvela-Jelaska, Ljiljana, Pelletier, Josephine, Dinallo, Roger, Panzenbeck, Mark, Torcellini, Carol, Nabozny, Gerald H, Thomson, David S

“…Syntheses and structure−activity relationships (SAR) of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain azaindole…”
Get full text

CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells by Lewis, Nuruddeen D, Muthukumarana, Akalushi, Fogal, Steven E, Corradini, Laura, Stefanopoulos, Dimitria E, Adusumalli, Prathima, Pelletier, Josephine, Panzenbeck, Mark, Berg, Karen, Canfield, Melissa, Cook, Brian N, Razavi, Hossein, Kuzmich, Daniel, Anderson, Shawn, Allard, Devan, Harrison, Paul, Grimaldi, Christine, Souza, Donald, Harcken, Christian, Fryer, Ryan M, Modis, Louise K, Brown, Maryanne L

“…Inflammation is associated with immune cells infiltrating into the inflammatory site and pain. CC chemokine receptor 1 (CCR1) mediates trafficking of…”
Get full text

Indole Inhibitors of MMP-13 for Arthritic Disorders by Taylor, Steven J, Abeywardane, Asitha, Liang, Shuang, Xiong, Zhaoming, Proudfoot, John R, Farmer, Bennett Sandy, Gao, Donghong A, Heim-Riether, Alexander, Smith-Keenan, Lana Louise, Muegge, Ingo, Yu, Yang, Zhang, Qiang, Souza, Donald, Panzenbeck, Mark, Goldberg, Daniel, Hill-Drzewi, Melissa, Margarit, Mariana, Collins, Brandon, Li, John Xiang, Zuvela-Jelaska, Ljiljana, Li, Jun, Farrow, Neil A

“…Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of…”
Get full text

Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores by Betageri, Raj, Gilmore, Thomas, Kuzmich, Daniel, Kirrane, Thomas M., Bentzien, Jörg, Wiedenmayer, Dieter, Bekkali, Younes, Regan, John, Berry, Angela, Latli, Bachir, Kukulka, Alison J., Fadra, Tazmeen N., Nelson, Richard M., Goldrick, Susan, Zuvela-Jelaska, Ljiljana, Souza, Don, Pelletier, Josephine, Dinallo, Roger, Panzenbeck, Mark, Torcellini, Carol, Lee, Heewon, Pack, Edward, Harcken, Christian, Nabozny, Gerald, Thomson, David S.

“…We report a SAR of non-steroidal glucocorticoid mimetics that utilize indoles as A-ring mimetics. A detailed SAR is discussed with a focus on improving PR and…”
Get full text

The potent and selective RIPK2 inhibitor BI 706039 improves intestinal inflammation in the TRUC mouse model of inflammatory bowel disease by Ermann, Joerg, Matmusaev, Mederbek, Haley, Emma K, Braun, Clemens, Jost, Felix, Mayer-Wrangowski, Svenja, Hsiao, Peng, Ting, Naitee, Li, Li, Terenzio, Donna, Chime, Jane, Lukas, Susan, Patnaude, Lori, Panzenbeck, Mark, Csordas, David, Zheng, Jie, Mierz, Diane, Simpson, Tom, King, F James, Klimowicz, Alex P, Mbow, M Lamine, Fine, Jay S, Miller, Craig A, Fogal, Steve E, Byrne, Fergus R

“…Mouse and human data implicate the NOD1 and NOD2 sensors of the intestinal microbiome and the associated signal transduction via the receptor interacting…”
Get more information

BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis by Chalmers, Samantha A., Glynn, Elizabeth, Garcia, Sayra J., Panzenbeck, Mark, Pelletier, Josephine, Dimock, Janice, Seccareccia, Elise, Bosanac, Todd, Khalil, Sara, Harcken, Christian, Webb, Deborah, Nabozny, Gerald, Fine, Jay S., Souza, Donald, Klein, Elliott, Herlitz, Leal, Ramanujam, Meera, Putterman, Chaim

“…Lupus nephritis is a common disease manifestation of SLE, in which immune complex deposition and macrophage activation are important contributors to disease…”
Get full text

Fr482 BI 706039 IS A POTENT AND SELECTIVE INHIBITOR OF RIPK2 AND IMPROVES INTESTINAL INFLAMMATION IN THE TRUC MOUSE MODEL OF INFLAMMATORY BOWEL DISEASE by Ermann, Joerg, Matmusaev, Mederbek, Haley, Emma, Braun, Clemens, Jost, Felix, Mayer-Wrangowski, Svenja, Ting, Naitee, Li, Frank, Terenzio, Donna, Chime, Jane, Lukas, Susan, Panzenbeck, Mark, Csordas, David, Zheng, Jie, Mierz, Diane, King, Frank J., Klimowicz, Alexander C., Fine, Jay S., Miller, Craig, Fogal, Steve, Byrne, Fergus

Get full text

Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357 by Harcken, Christian, Csengery, Johanna, Turner, Michael, Wu, Lifen, Liang, Shuang, Sibley, Robert, Brunette, Steven, Labadia, Mark, Hoyt, Kathleen, Wayne, Anita, Wieckowski, Thomas, Davis, Gregg, Panzenbeck, Mark, Souza, Donald, Kugler, Stanley, Terenzio, Donna, Collin, Delphine, Smith, Dustin, Fryer, Ryan M, Tseng, Yin-Chao, Hehn, Jörg P, Fletcher, Kim, Hughes, Robert O

“…The interleukin (IL)-23/T helper (Th)17 axis plays a critical role in autoimmune diseases, and there is an increasing number of biologic therapies that target…”
Get full text

Fecal MicroRNAs Show Promise as Noninvasive Crohn's Disease Biomarkers by Wohnhaas, Christian T, Schmid, Ramona, Rolser, Marcel, Kaaru, Eric, Langgartner, Dominik, Rieber, Kathrin, Strobel, Benjamin, Eisele, Claudia, Wiech, Franziska, Jakob, Ines, Gantner, Florian, Herichova, Ivona, Vinisko, Richard, Böcher, Wulf O, Visvanathan, Sudha, Shen, Fei, Panzenbeck, Mark, Raymond, Ernest, Reber, Stefan O, Delić, Denis, Baum, Patrick

“…Short non-coding microRNAs (miRNAs) are involved in various cellular processes during disease progression of Crohn's disease (CD) and remarkably stable in…”
Get full text

Identification and characterization of an antagonistic anti-mouse CD40 antibody by Ralph, Kerry L. M., Panzenbeck, Mark, Xiao, Haiguang, Frego, Lee, Bigwarfe, Tammy, Waltz, Erica, Grimaldi, Christine, Last-Barney, Kathy, Souza, Don, Brodeur, Scott, Nabozny, Gerald, Fine, Jay S., Distler, Jorg H. W., Ramanujam, Meera

“…Abstract Targeting CD40-CD40L interactions has been an interesting drug concept for the treatment of autoimmune diseases given this pathway’s role in the…”
Get full text

BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells by Lamb, David J, Wollin, Stefan Lutz, Schnapp, Andreas, Bischoff, Daniel, Erb, Klaus J, Bouyssou, Thierry, Guilliard, Bernd, Strasser, Christine, Wex, Eva, Blum, Sylvia, Thaler, Eva, Nickel, Helga, Radmacher, Oliver, Haas, Hannah, Swantek, Jennifer L, Souza, Don, Canfield, Melissa, White, Della, Panzenbeck, Mark, Kashem, Mohammed A, Sanville-Ross, Mary, Kono, Takeshi, Sewald, Katherina, Braun, Armin, Obernolte, Helena, Danov, Olga, Schaenzle, Gerhard, Rast, Georg, Maier, Gerd-Michael, Hoffmann, Matthias

“…BI 1002494 [(R)-4-{(R)-1-[7-(3,4,5-trimethoxy-phenyl)-[1,6]napthyridin-5-yloxy]-ethyl}pyrrolidin-2-one] is a novel, potent, and selective spleen tyrosine…”
Get more information

An RORγt oral inhibitor modulates IL-17 responses in peripheral blood and intestinal mucosa of Crohn's disease patients by Bassolas Molina, Helena, Raymond, Ernest, Labadia, Mark, Wahle, Joseph, Ferrer Picón, Elena, Panzenbeck, Mark, Zheng, Jie, Harcken, Christian, Hughes, Robert, Turner, Michael, Smith, Dustin, Calderón-Gómez, Elisabeth, Esteller, Míriam, Carrasco García, Anna, Esteve i Comas, Maria, Dotti, Isabella, Corraliza, Ana Maria, Masamunt, Maria Carme, Arajol, Claudia, Guardiola, Jordi, Ricart, Elena, Nabozny, Gerald, Salas Martínez, Azucena

“…Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants…”
Get full text

An RORγt oral inhibitor modulates IL-17 responses in peripheral blood and intestinal mucosa of Crohn's disease patients by Bassolas Molina, Helena, Raymond, Ernest, Labadia, Mark, Wahle, Joseph, Ferrer Picón, Elena, Panzenbeck, Mark, Zheng, Jie, Harcken, Christian, Hughes, Robert, Turner, Michael, Smith, Dustin, Calderón-Gómez, Elisabeth, Esteller, Míriam, Carrasco García, Anna, Esteve i Comas, Maria, Dotti, Isabella, Corraliza, Ana Maria, Masamunt, Maria Carme, Arajol, Claudia, Guardiola, Jordi, Ricart, Elena, Nabozny, Gerald, Salas Martínez, Azucena

“…Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants…”
Get full text

Discovery of a potent and dissociated non-steroidal glucocorticoid receptor agonist containing an alkyl carbinol pharmacophore by Razavi, Hossein, Riether, Doris, Harcken, Christian, Bentzien, Jörg, Dinallo, Roger M, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra-Khan, Tazmeen N, Pack, Jr, Edward J, Zuvela-Jelaska, Ljiljana, Pelletier, Josephine, Panzenbeck, Mark, Torcellini, Carol A, Proudfoot, John R, Nabozny, Gerald H, Thomson, David S

“…Synthesis and structure-activity relationship (SAR) of a series of alkyl and cycloalkyl containing non-steroidal dissociated glucocorticoid receptor (GR)…”
Get full text

The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function by Noonan, Thomas, Lukas, Susan, Peet, Gregory W, Pelletier, Josephine, Panzenbeck, Mark, Hanidu, Adedayo, Mazurek, Suzanne, Wasti, Ruby, Rybina, Irina, Roma, Teresa, Kronkaitis, Anthony, Shoultz, Alycia, Souza, Donald, Jiang, Huiping, Nabozny, Gerald, Modis, Louise Kelly

“…Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and is suggested to play a role in immune cell…”
Get full text