Perinatal exposure to low doses of glyphosate-based herbicide combined with a high-fat diet in adulthood causes changes in the jejunums of mice

Exposure to pesticides and consumption of high-fat diets are widespread in society. Reports have shown that exposure to glyphosate and a high-fat diet can cause gastrointestinal disorders and increase susceptibility to obesity. Thus, this study evaluated the impacts of perinatal exposure to glyphosa...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 275; p. 119350
Main Authors:	Panza, S.B., Vargas, R., Balbo, S.L., Bonfleur, M.L., Granzotto, D.C.T., Sant'Ana, D.M.G., Nogueira-Melo, G.A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 15-06-2021 Elsevier BV
Subjects:	Animals Collagen Consumption Crypts Diet Diet, High-Fat - adverse effects Enteric nervous system Exposure Female Fibers Gastrointestinal diseases Glycine - adverse effects Glycine - analogs & derivatives Glyphosate Glyphosate. High-fat diet. Small intestine. Enteric nervous system Goblet cells Goblet Cells - drug effects Goblet Cells - pathology Herbicides Herbicides - adverse effects High fat diet Histology Intestine Jejunum Jejunum - drug effects Jejunum - pathology Lactation Lymphocytes Male Mice Mice, Inbred C57BL Morphometry Nervous system Neurons Offspring Perinatal exposure Pesticides Pregnancy Prenatal Exposure Delayed Effects - chemically induced Small intestine Glyphosate. High-fat diet. Small intestine. Enteric nervous system
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Summary:	Exposure to pesticides and consumption of high-fat diets are widespread in society. Reports have shown that exposure to glyphosate and a high-fat diet can cause gastrointestinal disorders and increase susceptibility to obesity. Thus, this study evaluated the impacts of perinatal exposure to glyphosate followed by consumption of a high-fat diet in adulthood on the histology and morphometry of jejunums and enteric nervous system of C57BL/6 mice. After mating, 20 C57BL/6 female mice were separated into a control group (CG) and a glyphosate group (GLY) that received water with 0.5% glyphosate. After the lactation period, some male offspring were randomly separated into CG-SD and GLY-SD (standard diet) groups or CG-HD and GLY-HD (high-fat diet) groups. After 12 weeks, jejunum samples were collected and submitted to histological analysis. Indirect exposure to glyphosate changed the morphometry of the intestinal wall, increased the proportion of intraepithelial lymphocytes (IELs) and goblet cells, and altered the area occupied by collagen fibers. The hyperlipidemic diet hypertrophied the jejunal total wall, total muscular and submucosal layers, decreased IELs, and increased the proportion of goblet cells. GLY-HD mice had shallower crypts, shorter villi, and less goblet cells and IELs than mice from GLY-SD group. GLY-HD also showed an increased number of neurons in myenteric and submucosal plexuses. Groups exposed to glyphosate and/or fed a high-fat diet had atrophied submucosal neurons. This study suggests that perinatal glyphosate exposure combined with a high-fat diet in adulthood increases the risk of jejunum inflammation and dysfunction. •Perinatal exposure to glyphosate changed the morphometry, goblet cells and collagen fibers in the jejunum of mice.•Hyperlipidic diet hypertrophied the muscular and submucosa layers, and changed the proportion of cells.•Perinatal glyphosate exposure combined with a high-fat diet in adulthood (GLY-HD) altered myenteric and submucosal neurons.•GLY-HD mice had shallower crypts, shorter villi, and less goblet cells and intraepithelial lymphocytes.•Perinatal glyphosate exposure combined with a high-fat diet in adulthood might increase the risk of jejunum inflammation.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2021.119350