Search Results - "Pantesco, Veronique"
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Using intracellular SCGB1A1-sorted, formalin-fixed club cells for successful transcriptomic analysis
Published in Biochemical and biophysical research communications (14-05-2022)“…As opposed to surface marker staining, certain cell types can only be recognized by intracellular markers. Intracellular staining for use in cell sorting…”
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Platelets Purification Is a Crucial Step for Transcriptomic Analysis
Published in International journal of molecular sciences (13-03-2022)“…Platelets are small anucleate cells derived from the fragmentation of megakaryocytes and are involved in different biological processes especially hemostasis,…”
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Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients
Published in Biomedicines (14-07-2023)“…Senescent cells promote progressive tissue degeneration through the establishment of a combined inflammatory and trophic microenvironment. The cellular…”
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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
Published in Nature cell biology (01-11-2009)“…Topoisomerase I, together with the splicing factor ASF/SF2, prevents the collapse of replication forks by inhibiting the formation of RNA–DNA hybrids during…”
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dNTP pools determine fork progression and origin usage under replication stress
Published in The EMBO journal (15-02-2012)“…Intracellular deoxyribonucleoside triphosphate (dNTP) pools must be tightly regulated to preserve genome integrity. Indeed, alterations in dNTP pools are…”
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The Histone Deacetylases Sir2 and Rpd3 Act on Ribosomal DNA to Control the Replication Program in Budding Yeast
Published in Molecular cell (22-05-2014)“…In S. cerevisiae, replication timing is controlled by epigenetic mechanisms restricting the accessibility of origins to limiting initiation factors. About 30%…”
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Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response
Published in Nature structural & molecular biology (01-11-2010)“…A genome-wide analysis of replication profiles in different budding yeast mutants reveals that the alternative clamp loader component Ctf18 has a key role in…”
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AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2
Published in Neoplasia (New York, N.Y.) (01-06-2018)“…AICAR (Acadesine) is a pharmacological precursor of purine nucleotide biosynthesis with anti-tumoral properties. Although recognized as an AMP mimetic…”
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Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma
Published in Blood (01-06-2007)“…The heparan sulfate (HS) proteoglycan, syndecan-1, plays a major role in multiple myeloma (MM) by concentrating heparin-binding growth factors on the surface…”
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Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell
Published in Nucleic acids research (02-06-2017)“…MicroRNAs (miRNAs) are small noncoding RNAs that attenuate expression of their mRNA targets. Here, we developed a new method and an R package, to easily infer…”
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A gene expression signature shared by human mature oocytes and embryonic stem cells
Published in BMC genomics (08-01-2009)“…The first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate…”
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Temporal analysis of genome alterations induced by single-cell passaging in human embryonic stem cells
Published in Stem cells and development (01-03-2015)“…Simplified culture conditions are essential for large-scale drug screening and medical applications of human pluripotent stem cells (hPSCs). However, hPSCs…”
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13
Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch
Published in Nature (London) (08-04-1993)“…During neurogenesis in Drosophila, groups of equipotential, neurally competent cells choose between epidermal and neural fates. Notch, a phylogenetically…”
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The human cumulus–oocyte complex gene-expression profile
Published in Human reproduction (Oxford) (01-07-2006)“…BACKGROUND: The understanding of the mechanisms regulating human oocyte maturation is still rudimentary. We have identified transcripts differentially…”
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Cancer/Testis Genes in Multiple Myeloma: Expression Patterns and Prognosis Value Determined by Microarray Analysis
Published in Journal of Immunology (01-03-2007)“…Cancer-testis (CT) Ags are expressed in testis and malignant tumors but rarely in nongametogenic tissues. Due to this pattern, they represent attractive…”
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A Meta‐Analysis of Human Embryonic Stem Cells Transcriptome Integrated into a Web‐Based Expression Atlas
Published in Stem cells (Dayton, Ohio) (01-04-2007)“…Microarray technology provides a unique opportunity to examine gene expression patterns in human embryonic stem cells (hESCs). We performed a meta‐analysis of…”
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Correlating global gene regulation to angiogenesis in the developing chick extra-embryonic vascular system
Published in PloS one (17-11-2009)“…Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. Determining genes,…”
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Gene expression of anti‐ and pro‐apoptotic proteins in malignant and normal plasma cells
Published in British journal of haematology (01-04-2009)“…Summary The survival of malignant plasma cells is a key event in disease occurrence, progression and chemoresistance. Using DNA‐microarrays, we analysed the…”
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Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma
Published in Haematologica (Roma) (01-04-2012)“…Genetic abnormalities are common in patients with multiple myeloma, and may deregulate gene products involved in tumor survival, proliferation, metabolism and…”
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Forced KLF4 expression increases the generation of mature plasma cells and uncovers a network linked with plasma cell stage
Published in Cell cycle (Georgetown, Tex.) (17-07-2016)“…A role of the transcription factor Krüppel-like factor 4 (KLF4) in the generation of mature plasma cells (PC) is unknown. Indeed, KLF4 is critical in…”
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