Search Results - "Pant, HC"

A novel CDK5‐dependent pathway for regulating GSK3 activity and kinesin‐driven motility in neurons by Morfini, Gerardo, Szebenyi, Györgyi, Brown, Hannah, Pant, Harish C, Pigino, Gustavo, DeBoer, Scott, Beffert, Uwe, Brady, Scott T

“…Neuronal transmission of information requires polarized distribution of membrane proteins within axonal compartments. Membrane proteins are synthesized and…”
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The Pathobiology of Amyotrophic Lateral Sclerosis: A Proteinopathy? by Strong, Michael J, Kesavapany, Sashi, Pant, Harish C

“…Amyotrophic lateral sclerosis (ALS) is increasingly considered to be a disorder of multiple etiologies that have in common progressive degeneration of both…”
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A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons by Zheng, Ya-Li, Kesavapany, Sashi, Gravell, Maneth, Hamilton, Rebecca S, Schubert, Manfred, Amin, Niranjana, Albers, Wayne, Grant, Philip, Pant, Harish C

“…The extracellular aggregation of amyloid β (Aβ) peptides and the intracellular hyperphosphorylation of tau at specific epitopes are pathological hallmarks of…”
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Cyclin-Dependent Kinase 5 Activity Regulates Pain Signaling by Pareek, Tej K., Keller, Jason, Kesavapany, Sashi, Pant, Harish C., Iadarola, Michael J., Brady, Roscoe O., Kulkarni, Ashok B.

“…Several molecules and cellular pathways have been implicated in nociceptive signaling, but their precise molecular mechanisms have not been clearly defined…”
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Regulation of NMDA Receptors by Cyclin-Dependent Kinase-5 by Li, Bing-Sheng, Sun, Miao-Kun, Zhang, Lei, Takahashi, Satoru, Ma, Wu, Vinade, Lucia, Kulkarni, Ashok B., Brady, Roscoe O., Pant, Harish C.

“…Members of the N-methyl-D-aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they…”
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Cyclin-dependent Kinase-5 Is Involved in Neuregulin-dependent Activation of Phosphatidylinositol 3-Kinase and Akt Activity Mediating Neuronal Survival by Li, Bing-Sheng, Ma, Wu, Jaffe, Howard, Zheng, Yali, Takahashi, Satoru, Zhang, Lei, Kulkarni, Ashok B., Pant, Harish C.

“…The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays an important role in mediating survival signals in wide variety of neurons and cells…”
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Peripheral and orofacial pain sensation is unaffected by the loss of p39 by Prochazkova, Michaela, Hall, Bradford, Hu, Minghan, Okine, Tracy, Reukauf, Jennifer, Binukumar, BK, Amin, Niranjana D, Roque, Eva, Pant, Harish C, Kulkarni, Ashok B

“…Cdk5 is a key neuronal kinase necessary for proper brain development, which has recently been implicated in modulating nociception. Conditional deletion of…”
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Calpain Mediates Calcium-Induced Activation of the Erk1,2 MAPK Pathway and Cytoskeletal Phosphorylation in Neurons: Relevance to Alzheimer's Disease by Veeranna, Kaji, Takahide, Boland, Barry, Odrljin, Tatjana, Mohan, Panaiyur, Basavarajappa, Balapal S, Peterhoff, Corrinne, Cataldo, Anne, Rudnicki, Anna, Amin, Niranjana, Li, Bing Sheng, Pant, Harish C, Hungund, Basalingappa L, Arancio, Ottavio, Nixon, Ralph A

“…Aberrant phosphorylation of the neuronal cytoskeleton is an early pathological event in Alzheimer's disease (AD), but the underlying mechanisms are unclear…”
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Cdk5 Regulates the Organization of Nestin and Its Association with p35 by Sahlgren, Cecilia M., Mikhailov, Andrey, Vaittinen, Samuli, Pallari, Hanna-Mari, Kalimo, Hannu, Pant, Harish C., Eriksson, John E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Targeted Disruption of the Cyclin-Dependent Kinase 5 Gene Results in Abnormal Corticogenesis, Neuronal Pathology and Perinatal Death by Ohshima, Toshio, Ward, Jerrold M., Huh, Chang-Goo, Longenecker, Glenn, Veeranna, Pant, Harish C., Brady, Roscoe O., Martin, Lee J., Kulkarni, Ashok B.

“…Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent kinases, its kinase activity is detected only in the postmitotic…”
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Differential expression of multiple transglutaminases in human brain. Increased expression and cross-linking by transglutaminases 1 and 2 in Alzheimer's disease by Kim, S Y, Grant, P, Lee, J H, Pant, H C, Steinert, P M

“…The transglutaminase (TGase) family of enzymes, of which seven different members are known in the human genome, participate in many biological processes…”
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Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3 by Li, Bing-Sheng, Zhang, Lei, Takahashi, Satoru, Ma, Wu, Jaffe, Howard, Kulkarni, Ashok B., Pant, Harish C.

“…Cyclin‐dependent kinase 5 (cdk5) is a serine/threonine kinase activated by associating with its neuron‐specific activators p35 and p39. Analysis of cdk5−/− and…”
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Does neurofilament phosphorylation regulate axonal transport? by Shea, Thomas B, Jung, Cheolwha, Pant, Harish C

“…Phosphorylation of neurofilaments has long been considered to regulate their axonal transport rate and, in doing so, to provide stability to mature axons…”
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Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway by Sharma, Pushkar, Veeranna, Sharma, Monica, Amin, Niranjana D., Sihag, Ram K., Grant, Philip, Ahn, Natalie, Kulkarni, Ashok B., Pant, Harish C.

“…Cyclin-dependent protein kinase 5 (cdk5), a member of the cdk family, is active mainly in postmitotic cells and plays important roles in neuronal development…”
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Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment by STRONG, M. J, YANG, W, STRONG, W. L, LEYSTRA-LANTZ, C, JAFFE, H, PANT, H. C

“…The authors have characterized frontal cortical tau protein in cognitively intact (4) and cognitively impaired (ALSci, 4) ALS patients and compared it with…”
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Control of cyclin‐dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability by Wei, Fan‐Yan, Tomizawa, Kazuhito, Ohshima, Toshio, Asada, Akiko, Saito, Taro, Nguyen, Chan, Bibb, James A., Ishiguro, Koichi, Kulkarni, Ashok B., Pant, Harish C., Mikoshiba, Katsuhiko, Matsui, Hideki, Hisanaga, Shin‐ichi

“…Although the roles of cyclin‐dependent kinase 5 (Cdk5) in neurodevelopment and neurodegeneration have been studied extensively, regulation of Cdk5 activity has…”
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Increased Activity of Cyclin-Dependent Kinase 5 Leads to Attenuation of Cocaine-Mediated Dopamine Signaling by Takahashi, Satoru, Ohshima, Toshio, Cho, Andrew, Sreenath, Taduru, Iadarola, Michael J., Pant, Harish C., Kim, Yong, Nairn, Angus C., Brady, Roscoe O., Greengard, Paul, Kulkarni, Ashok B.

“…Cocaine, a drug of abuse, increases synaptic dopamine levels in the striatum by blocking dopamine reuptake at axon terminals. Cyclin-dependent kinase 5 (Cdk5)…”
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Characterization of Serine and Threonine Phosphorylation Sites in β-Elimination/Ethanethiol Addition-Modified Proteins by Electrospray Tandem Mass Spectrometry and Database Searching by Jaffe, Howard, Veeranna, Pant, Harish C

“…A new method for the characterization of serine and threonine phosphorylation sites in proteins has been developed. After modification of a phosphoprotein by…”
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Myelin‐associated glycoprotein modulates expression and phosphorylation of neuronal cytoskeletal elements and their associated kinases by Dashiell, Suzanne M., Tanner, Sandra L., Pant, Harish C., Quarles, Richard H.

“…Decreased phosphorylation of neurofilaments in mice lacking myelin‐associated glycoprotein (MAG) was shown to be associated with decreased activities of…”
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Tau Phosphorylation by Cyclin-dependent Kinase 5/p39 during Brain Development Reduces Its Affinity for Microtubules by Takahashi, Satoru, Saito, Taro, Hisanaga, Shin-ichi, Pant, Harish C, Kulkarni, Ashok B

“…The microtubule-associated protein tau is a developmentally regulated neuronal phosphoprotein. The phosphorylation of tau reduces its ability to bind and…”
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