Search Results - "Pannella, Micaela"
-
1
Impairment of human dopaminergic neurons at different developmental stages by perfluoro-octanoic acid (PFOA) and differential human brain areas accumulation of perfluoroalkyl chemicals
Published in Environment international (01-01-2022)“…[Display omitted] Perfluoroalkyl substances (PFASs) are synthetic chemicals widely used in industrial and consumer products. The environmental spreading of…”
Get full text
Journal Article -
2
A novel patient-derived immortalised cell line of myxofibrosarcoma: a tool for preclinical drugs testing and the generation of near-patient models
Published in BMC cancer (06-12-2023)“…Myxofibrosarcoma is a rare malignant soft tissue sarcoma characterised by multiple local recurrence and can become of higher grade with each recurrence…”
Get full text
Journal Article -
3
Thyroid Hormone Signaling in Embryonic Stem Cells: Crosstalk with the Retinoic Acid Pathway
Published in International journal of molecular sciences (25-11-2020)“…While the role of thyroid hormones (THs) during fetal and postnatal life is well-established, their role at preimplantation and during blastocyst development…”
Get full text
Journal Article -
4
17β-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells
Published in PloS one (13-08-2013)“…Estrogens play a protective role in coronary artery disease. The mechanisms of action are still poorly understood, although a role for estrogens in stimulation…”
Get full text
Journal Article -
5
Exposure to Perfluoro-Octanoic Acid Associated With Upstream Uncoupling of the Insulin Signaling in Human Hepatocyte Cell Line
Published in Frontiers in endocrinology (Lausanne) (03-09-2021)“…Perfluoro-alkyl substances (PFAS) are chemical pollutants with prevalent stability and environmental persistence. Exposure to PFAS, particularly…”
Get full text
Journal Article -
6
Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study
Published in Journal of translational medicine (04-05-2017)“…The lack of early diagnosis, progression markers and effective pharmacological treatment has dramatic unfavourable effects on clinical outcomes in patients…”
Get full text
Journal Article -
7
Experimental evidence of a limited impact of new-generation perfluoroalkyl substance C6O4 on differentiating human dopaminergic neurons from induced pluripotent stem cells
Published in Toxicology reports (01-01-2023)“…Perfluoroalkyl substances (PFASs) are persistent pollutants, raising concerns for human health. Legacy PFAS perfluoro-octanoic acid (PFOA) accumulate in brains…”
Get full text
Journal Article -
8
NEST3D printed bone-mimicking scaffolds: assessment of the effect of geometrical design on stiffness and angiogenic potential
Published in Frontiers in cell and developmental biology (07-03-2024)“…Tissue-engineered implants for bone regeneration require consideration regarding their mineralization and vascularization capacity. Different geometries, such…”
Get full text
Journal Article -
9
Xenografting Human Musculoskeletal Sarcomas in Mice, Chick Embryo, and Zebrafish: How to Boost Translational Research
Published in Biomedicines (01-08-2024)“…Musculoskeletal sarcomas pose major challenges to researchers and clinicians due to their rarity and heterogeneity. Xenografting human cells or tumor fragments…”
Get full text
Journal Article -
10
In Vitro Endothelial Cell Proliferation Assay Reveals Distinct Levels of Proangiogenic Cytokines Characterizing Sera of Healthy Subjects and of Patients with Heart Failure
Published in Mediators of Inflammation (01-01-2014)“…Although myocardial angiogenesis is thought to play an important role in heart failure (HF), the involvement of circulating proinflammatory and proangiogenic…”
Get full text
Journal Article -
11
A dynamic culture platform enhances the efficiency of the 3D HUVEC‐based tube formation assay
Published in Biotechnology and bioengineering (01-03-2020)“…Cell‐based in vitro biological models traditionally use monolayer cell cultures grown over plastic surfaces bathing in static media. Higher fidelity to a…”
Get full text
Journal Article -
12
Estrogen receptor β–dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis
Published in The Journal of biological chemistry (03-11-2017)“…Unlike age-matched men, premenopausal women benefit from cardiovascular protection. Estrogens protect against apoptosis of endothelial cells (ECs), one of the…”
Get full text
Journal Article -
13
Molecular mechanisms of skin wound healing in non-diabetic and diabetic mice in excision and pressure experimental wounds
Published in Cell and tissue research (01-06-2022)“…Experimental models for chronic skin lesions are excision and pressure ulcer, defined as “open” and “closed” lesions, respectively, only the latter…”
Get full text
Journal Article -
14
Extragonadal function of follicle-stimulating hormone: Evidence for a role in endothelial physiology and dysfunction
Published in Molecular and cellular endocrinology (01-12-2024)“…Follicle-stimulating hormone (FSH) plays a fundamental role in reproduction stimulating ovarian folliculogenesis, Sertoli cells function and spermatogenesis…”
Get full text
Journal Article -
15
Modeling Myxofibrosarcoma: Where Do We Stand and What Is Missing?
Published in Cancers (01-11-2023)“…Myxofibrosarcoma (MFS) is a malignant soft tissue sarcoma (STS) that originates in the body’s connective tissues. It is characterized by the presence of myxoid…”
Get full text
Journal Article -
16
Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels
Published in Science advances (01-09-2023)“…In myelinating Schwann cells, connection between myelin layers is mediated by gap junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels…”
Get full text
Journal Article -
17
Serum From Advanced Heart Failure Patients Promotes Angiogenic Sprouting and Affects the Notch Pathway in Human Endothelial Cells
Published in Journal of cellular physiology (01-12-2016)“…It is unknown whether components present in heart failure (HF) patients’ serum provide an angiogenic stimulus. We sought to determine whether serum from HF…”
Get full text
Journal Article -
18
Abstract 2419: A multimodel preclinical platform to evaluate photodynamic therapy as a strategy to reduce local recurrence in myxofibrosarcoma and osteosarcoma
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Sarcomas are heterogeneous and rare malignant tumors that develop from connective tissues. Myxofibrosarcoma (MFS) and Osteosarcoma (OS) are the main…”
Get full text
Journal Article -
19
17[beta]-Estradiol Enhances Signalling Mediated by VEGF-A-Delta-Like Ligand 4-Notch1 Axis in Human Endothelial Cells
Published in PloS one (13-08-2013)“…Estrogens play a protective role in coronary artery disease. The mechanisms of action are still poorly understood, although a role for estrogens in stimulation…”
Get full text
Journal Article -
20
The role of notch in the cardiovascular system: potential adverse effects of investigational notch inhibitors
Published in Frontiers in oncology (13-01-2015)“…Targeting the Notch pathway is a new promising therapeutic approach for cancer patients. Inhibition of Notch is effective in the oncology setting because it…”
Get full text
Journal Article