Search Results - "Panman, Matthijs"
-
1
Guanidinium-Induced Denaturation by Breaking of Salt Bridges
Published in Angewandte Chemie International Edition (07-12-2015)“…Despite its wide use as a denaturant, the mechanism by which guanidinium (Gdm+) induces protein unfolding remains largely unclear. Herein, we show evidence…”
Get full text
Journal Article -
2
Accelerating the Shuttling in Hydrogen-Bonded Rotaxanes: Active Role of the Axle and the End Station
Published in Journal of the American Chemical Society (04-12-2019)“…The relation between the chemical structure and the mechanical behavior of molecular machines is of paramount importance for a rational design of superior…”
Get full text
Journal Article -
3
On the (un)coupling of the chromophore, tongue interactions, and overall conformation in a bacterial phytochrome
Published in The Journal of biological chemistry (25-05-2018)“…Phytochromes are photoreceptors in plants, fungi, and various microorganisms and cycle between metastable red light–absorbing (Pr) and far-red light–absorbing…”
Get full text
Journal Article -
4
The primary structural photoresponse of phytochrome proteins captured by a femtosecond X-ray laser
Published in eLife (31-03-2020)“…Phytochrome proteins control the growth, reproduction, and photosynthesis of plants, fungi, and bacteria. Light is detected by a bilin cofactor, but it remains…”
Get full text
Journal Article -
5
Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
Published in Nature communications (18-08-2017)“…Sensor histidine kinases are central to sensing in bacteria and in plants. They usually contain sensor, linker, and kinase modules and the structure of many of…”
Get full text
Journal Article -
6
Observing the Structural Evolution in the Photodissociation of Diiodomethane with Femtosecond Solution X-Ray Scattering
Published in Physical review letters (27-11-2020)“…Resolving the structural dynamics of the initial steps of chemical reactions is challenging. We report the femtosecond time-resolved wide-angle x-ray…”
Get full text
Journal Article -
7
Solvent-Dependent Structural Dynamics in the Ultrafast Photodissociation Reaction of Triiodide Observed with Time-Resolved X‑ray Solution Scattering
Published in Journal of the American Chemical Society (26-07-2023)“…Resolving the structural dynamics of bond breaking, bond formation, and solvation is required for a deeper understanding of solution-phase chemical reactions…”
Get full text
Journal Article -
8
Unraveling VEALYL Amyloid Formation Using Advanced Vibrational Spectroscopy and Microscopy
Published in Biophysical journal (07-07-2020)“…Intermediate species are hypothesized to play an important role in the toxicity of amyloid formation, a process associated with many diseases. This process can…”
Get full text
Journal Article -
9
Water lubricates hydrogen-bonded molecular machines
Published in Nature chemistry (01-11-2013)“…The mechanical behaviour of molecular machines differs greatly from that of their macroscopic counterparts. This applies particularly when considering concepts…”
Get full text
Journal Article -
10
Folding Dynamics of the Trp-Cage Miniprotein: Evidence for a Native-Like Intermediate from Combined Time-Resolved Vibrational Spectroscopy and Molecular Dynamics Simulations
Published in The journal of physical chemistry. B (03-10-2013)“…Trp-cage is a synthetic 20-residue miniprotein which folds rapidly and spontaneously to a well-defined globular structure more typical of larger proteins. Due…”
Get full text
Journal Article -
11
Time-Resolved X-Ray Solution Scattering Reveals the Structural Photoactivation of a Light-Oxygen-Voltage Photoreceptor
Published in Structure (London) (06-06-2017)“…Light-oxygen-voltage (LOV) receptors are sensory proteins controlling a wide range of organismal adaptations in multiple kingdoms of life. Because of their…”
Get full text
Journal Article -
12
Folding of a Zinc-Finger ββα-Motif Investigated Using Two-Dimensional and Time-Resolved Vibrational Spectroscopy
Published in The journal of physical chemistry. B (03-11-2016)“…Small proteins provide good model systems for studying the fundamental forces that control protein folding. Here, we investigate the folding dynamics of the…”
Get full text
Journal Article -
13
Structural photoactivation of a full-length bacterial phytochrome
Published in Science advances (01-08-2016)“…Phytochromes are light sensor proteins found in plants, bacteria, and fungi. They function by converting a photon absorption event into a conformational signal…”
Get full text
Journal Article -
14
Operation Mechanism of a Molecular Machine Revealed Using Time-Resolved Vibrational Spectroscopy
Published in Science (American Association for the Advancement of Science) (04-06-2010)“…Rotaxanes comprise macrocycles that can shuttle between docking stations along an axle. We explored the nanosecond shuttling mechanism by reversing the…”
Get full text
Journal Article -
15
Transient two-dimensional vibrational spectroscopy of an operating molecular machine
Published in Nature communications (20-12-2017)“…Synthetic molecular machines are promising building blocks for future nanoscopic devices. However, the details of their mechanical behaviour are in many cases…”
Get full text
Journal Article -
16
Light-induced structural changes in a monomeric bacteriophytochrome
Published in Structural dynamics (Melville, N.Y.) (01-09-2016)“…Phytochromes sense red light in plants and various microorganism. Light absorption causes structural changes within the protein, which alter its biochemical…”
Get full text
Journal Article -
17
The room temperature crystal structure of a bacterial phytochrome determined by serial femtosecond crystallography
Published in Scientific reports (19-10-2016)“…Phytochromes are a family of photoreceptors that control light responses of plants, fungi and bacteria. A sequence of structural changes, which is not yet…”
Get full text
Journal Article -
18
Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase
Published in Science advances (08-12-2023)“…Cytochrome oxidase (C O) is part of the respiratory chain and contributes to the electrochemical membrane gradient in mitochondria as well as in many bacteria,…”
Get full text
Journal Article -
19
Photoactivation of Drosophila melanogaster cryptochrome through sequential conformational transitions
Published in Science advances (17-07-2019)“…Cryptochromes are blue-light photoreceptor proteins, which provide input to circadian clocks. The cryptochrome from ( Cry) modulates the degradation of…”
Get full text
Journal Article -
20
Amplifying vibrational circular dichroism by manipulation of the electronic manifold
Published in Chemical communications (Cambridge, England) (01-01-2012)“…Vibrational circular dichroism is a powerful technique to study the stereochemistry of chiral molecules, but often suffers from small signal intensities…”
Get more information
Journal Article