Search Results - "Pankratz, Matthew T"
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Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure
Published in Science (American Association for the Advancement of Science) (18-12-2015)“…Dysfunction of microRNA (miRNA) metabolism is thought to underlie diseases affecting motoneurons. One miRNA, miR-218, is abundantly and selectively expressed…”
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Directed Neural Differentiation of Human Embryonic Stem Cells via an Obligated Primitive Anterior Stage
Published in Stem cells (Dayton, Ohio) (01-06-2007)“…Understanding neuroectoderm formation and subsequent diversification to functional neural subtypes remains elusive. We show here that human embryonic stem…”
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Speed and segmentation control mechanisms characterized in rhythmically-active circuits created from spinal neurons produced from genetically-tagged embryonic stem cells
Published in eLife (14-02-2017)“…Flexible neural networks, such as the interconnected spinal neurons that control distinct motor actions, can switch their activity to produce different…”
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Central Nervous System Metabolism in Autism, Epilepsy and Developmental Delays: A Cerebrospinal Fluid Analysis
Published in Metabolites (20-04-2022)“…Neurodevelopmental disorders are associated with metabolic pathway imbalances; however, most metabolic measurements are made peripherally, leaving central…”
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Increases in the phosphorylation of cyclic AMP response element binding protein (CREB) and decreases in the content of calcineurin accompany thermal hyperalgesia following chronic constriction injury in rats
Published in Pain (Amsterdam) (01-10-2002)“…Plasticity in the spinal dorsal horn may underlie the development of chronic pain following peripheral nerve injury or inflammation. In this study, we examined…”
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Human embryonic stem cells for brain repair?
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (12-01-2008)“…in vivo…”
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Pax6 Is a Human Neuroectoderm Cell Fate Determinant
Published in Cell stem cell (02-07-2010)“…The transcriptional regulation of neuroectoderm (NE) specification is unknown. Here we show that Pax6 is uniformly expressed in early NE cells of human fetuses…”
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Regulation of Neural Specification from Human Embryonic Stem Cells by BMP and FGF
Published in Stem cells (Dayton, Ohio) (01-08-2009)“…Inhibition of bone morphogenetic protein (BMP) signaling is required for vertebrate neural induction, and fibroblast growth factors (FGFs) may affect neural…”
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Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1
Published in Pain (Amsterdam) (01-09-2003)“…The inhibitory activity of gamma-aminobutyric acid (GABA) is considered critical in setting the conditions for synaptic plasticity, and many studies support an…”
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Chapter 241 - Signaling Pathways that Regulate Cell Fate in the Embryonic Spinal Cord
Published in Handbook of Cell Signaling (2009)“…This chapter provides an understanding on the developmental process of dorsal and ventral spinal cord. The embryonic dorsal spinal cord is made up of…”
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