Search Results - "Pankiewicz, K"

COVID-19-related premature ovarian insufficiency: case report and literature review by Pankiewicz, K, Chotkowska, E, Nowakowska, B, Gos, M, Issat, T

“…The aim of this study is to present the case report of a 36-year-old woman developing premature ovarian insufficiency (POI) after COVID-19 and review the…”
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Nicotinamide adenine dinucleotide based therapeutics by Chen, L, Petrelli, R, Felczak, K, Gao, G, Bonnac, L, Yu, J S, Bennett, E M, Pankiewicz, K W

“…Nicotinamide adenine dinucleotide (NAD), generally considered a key component involved in redox reactions, has been found to participate in an increasingly…”
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Rehab of NAD(P)-dependent enzymes with NAD(P)-based inhibitors by Felczak, K, Pankiewicz, K W

“…A large number of enzymes that use nicotinamide adenine dinucleotide NAD or its phosphorylated form NADP as a cofactor or substrate were found to play an…”
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Nicotinamide Adenine Dinucleotide Based Therapeutics, Update by Pankiewicz, K W, Petrelli, R, Singh, R, Felczak, K

“…About 500 NAD (P)-dependent enzymes in the cell use NAD (P) as a cofactor or a substrate. This family of broadly diversified enzymes is crucial for maintaining…”
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Crosstalk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication by Wang, Y, Wang, W, Xu, L, Zhou, X, Felczak, K, Van Der Laan, L, Pankiewicz, K, Sprengers, D, Metselaar, H, Peppelenbosch, M, Pan, Q

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Fluorinated nucleosides by Pankiewicz, Krzysztof W.

“…The synthesis and biological activity of deoxyfluoro nucleosides are reviewed…”
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Using Markers and Field Evaluation to Identify the Source of Eyespot Resistance Gene Pch1 in the Collection of Wheat Breeding Lines by Kwiatek, M., Wiśniewska, H., Kaczmarek, Z., Korbas, M., Gawłowska, M., Majka, M., Pankiewicz, K., Danielewicz, J., Belter, J.

“…Pch1 gene translocated from Aegilops ventricosa provides effective resistance to eyespot in wheat. To track the Pch1 gene introgression, we investigated 372…”
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Abstract No. 29: Early apoptosis and tumor response in N1-S1 rodent hepatomas to arterial versus intravenous benzamide riboside with monitoring by water apparent diffusion coefficient and 23Na MRI by Faramarzalian, A, McLennan, G, Bennett, S.L, Babsky, A, Bansal, N, Lieber, M, Bonnac, L, Pankiewicz, K, Jayaram, H.N

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Raman Spectroscopy of Uracil DNA Glycosylase−DNA Complexes:  Insights into DNA Damage Recognition and Catalysis by Dong, Jian, Drohat, Alexander C, Stivers, James T, Pankiewicz, Kryzsztof W, Carey, Paul R

“…Using off-resonance Raman spectroscopy, we have examined each complex along the catalytic pathway of the DNA repair enzyme uracil DNA glycosylase (UDG). The…”
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Kinetic Mechanism of Damage Site Recognition and Uracil Flipping by Escherichia coli Uracil DNA Glycosylase by Stivers, James T, Pankiewicz, Krzysztof W, Watanabe, Kyoichi A

“…The DNA repair enzyme uracil DNA glycosylase (UDG) catalyzes hydrolytic cleavage of the N-glycosidic bond of premutagenic uracil residues in DNA by flipping…”
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Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites by Stuyver, Lieven J, McBrayer, Tamara R, Tharnish, Phillip M, Hassan, Abdalla E A, Chu, Chung K, Pankiewicz, Krzysztof W, Watanabe, Kyochi A, Schinazi, Raymond F, Otto, Michael J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Crystallographic studies of two alcohol dehydrogenase-bound analogs of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin by Li, H, Hallows, W. A, Punzi, J. S, Marquez, V. E, Carrell, H. L, Pankiewicz, K. W, Watanabe, K. A, Goldstein, B. M

“…Thiazole-4-carboxamide adenine dinucleotide (TAD) is the active anabolite of the antitumor drug tiazofurin. Beta-methylene TAD (beta-TAD) is a…”
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Synthesis of Nonhydrolyzable Analogues of Thiazole-4-carboxamide and Benzamide Adenine Dinucleotide Containing Fluorine Atom at the C2‘ of Adenine Nucleoside: Induction of K562 Differentiation and Inosine Monophosphate Dehydrogenase Inhibitory Activity by Lesiak, Krystyna, Watanabe, Kyoichi A, Majumdar, Alokes, Seidman, Michael, Vanderveen, Kristen, Goldstein, Barry M, Pankiewicz, Krzysztof W

“…Thiazole-4-carboxamide adenine dinucleotide (TAD) analogue 7 containing a fluorine atom at the C2‘ arabino configuration of the adenine nucleoside moiety was…”
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The Practical Synthesis of a Methylenebisphosphonate Analogue of Benzamide Adenine Dinucleotide:  Inhibition of Human Inosine Monophosphate Dehydrogenase (Type I and II) by Pankiewicz, Krzysztof W, Lesiak, Krystyna, Zatorski, Andrzej, Goldstein, Barry M, Carr, Stephen F, Sochacki, Marek, Majumdar, Alokes, Seidman, Michael, Watanabe, Kyoichi A

“…β-Methylene-BAD (8), a nonhydrolyzable analogue of benzamide adenine dinucleotide (BAD), was synthesized as potential inhibitor of human inosine monophosphate…”
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Determination of the Tautomeric Equlibrium of Ψ-Uridine in the Basic Solution by Luyten, I, Pankiewicz, K. W, Watanabe, K. A, Chattopadhyaya, J

“…The pD-dependent 13C shift and 3 J CH of Ψ-uridine have shown that the pK a of its N1 and N3 are 9.6 and 9.3, respectively. For the monoanionic Ψ-uridine, the…”
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Synthesis of a Methylenebis(phosphonate) Analogue of Mycophenolic Adenine Dinucleotide:  A Glucuronidation-Resistant MAD Analogue of NAD by Lesiak, Krystyna, Watanabe, Kyoichi A, Majumdar, Alokes, Powell, James, Seidman, Michael, Vanderveen, Kristen, Goldstein, Barry M, Pankiewicz, Krzysztof W

“…Mycophenolic alcohol (MPAlc), obtained by reduction of the carboxylic group of mycophenolic acid (MPA), was coupled with 2‘,3‘-O-isopropylideneadenosine…”
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Novel mycophenolic adenine bis(phosphonate)s as potential immunosuppressants by Pankiewicz, K W, Lesiak-Watanabe, K, Watanabe, K A, Malinowski, K

“…Mycophenolic acid (MPA) is the most potent and specific inhibitor of inosine monophosphate dehydrogenase (IMPDH). This compound was reported to bind the NAD…”
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Chemical Synthesis of Benzamide Adenine Dinucleotide:  Inhibition of Inosine Monophosphate Dehydrogenase (Types I and II) by Zatorski, Andrzej, Watanabe, Kyoichi A, Carr, Stephen F, Goldstein, Barry M, Pankiewicz, Krzysztof W

“…Treatment of 3-(2,3-O-isopropylidene-β-d-ribofuranosyl)benzamide (6) with POCl3 in (EtO)3PO afforded only little phosphorylation product (8, 5%), but the major…”
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Heteronuclear NMR and Crystallographic Studies of Wild-Type and H187Q Escherichia coli Uracil DNA Glycosylase:  Electrophilic Catalysis of Uracil Expulsion by a Neutral Histidine 187 by Drohat, Alexander C, Xiao, Gaoyi, Tordova, Maria, Jagadeesh, Jaya, Pankiewicz, Krzysztof W, Watanabe, Kyoichi A, Gilliland, Gary L, Stivers, James T

“…The nature of the putative general acid His187 in the reaction catalyzed by Escherichia coli uracil DNA glycosylase (UDG) was investigated using X-ray…”
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Novel nicotinamide adenine dinucleotide analogues as potential anticancer agents: Quest for specific inhibition of inosine monophosphate dehydrogenase by Pankiewicz, Krzysztof W.

“…Synthetic nicotinamide adenine dinucleotide (NAD) analogues containing 5-β- d-ribofuranosylnicotinamide (C-NAD), 6-β- d-ribofuranosylpicolinamide (C-PAD), 3-β-…”
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