Search Results - "Panizzi, Peter"

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction by Heidt, Timo, Courties, Gabriel, Dutta, Partha, Sager, Hendrik B, Sebas, Matt, Iwamoto, Yoshiko, Sun, Yuan, Da Silva, Nicolas, Panizzi, Peter, van der Lahn, Anja M, Swirski, Filip K, Weissleder, Ralph, Nahrendorf, Matthias

“…RATIONALE:Macrophages populate the steady-state myocardium. Previously, all macrophages were thought to arise from monocytes; however, it emerged that, in…”
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Therapeutic siRNA silencing in inflammatory monocytes in mice by Weissleder, Ralph, Nahrendorf, Matthias, Leuschner, Florian, Dutta, Partha, Gorbatov, Rostic, Novobrantseva, Tatiana I, Donahoe, Jessica S, Courties, Gabriel, Lee, Kang Mi, Kim, James I, Markmann, James F, Marinelli, Brett, Panizzi, Peter, Lee, Won Woo, Iwamoto, Yoshiko, Milstein, Stuart, Epstein-Barash, Hila, Cantley, William, Wong, Jamie, Cortez-Retamozo, Virna, Newton, Andita, Love, Kevin, Libby, Peter, Pittet, Mikael J, Swirski, Filip K, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G

“…In vivo silencing in specific cell types remains the main obstacle for therapeutic applications of siRNAs. Leuschner et al . now show that an optimized lipid…”
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Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis by Leuschner, Florian, Rauch, Philipp J, Ueno, Takuya, Gorbatov, Rostic, Marinelli, Brett, Lee, Won Woo, Dutta, Partha, Wei, Ying, Robbins, Clinton, Iwamoto, Yoshiko, Sena, Brena, Chudnovskiy, Aleksey, Panizzi, Peter, Keliher, Edmund, Higgins, John M, Libby, Peter, Moskowitz, Michael A, Pittet, Mikael J, Swirski, Filip K, Weissleder, Ralph, Nahrendorf, Matthias

“…Monocytes (Mo) and macrophages (MΦ) are emerging therapeutic targets in malignant, cardiovascular, and autoimmune disorders. Targeting of Mo/MΦ and their…”
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Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis by NAHRENDORF, Matthias, HANWEN ZHANG, HEMBRADOR, Sheena, PANIZZI, Peter, SOSNOVIK, David E, AIKAWA, Elena, LIBBY, Peter, SWIRSKI, Filip K, WEISSLEDER, Ralph

“…Macrophages participate centrally in atherosclerosis, and macrophage markers (eg, CD68, MAC-3) correlate well with lesion severity and therapeutic modulation…”
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Gentamicin Eluting 3D-Printed Implants for Preventing Post-Surgical Infections in Bone Fractures by Poudel, Ishwor, Annaji, Manjusha, Zhang, Chu, Panizzi, Peter R., Arnold, Robert D., Kaddoumi, Amal, Amin, Rajesh H., Lee, Seungjong, Shamsaei, Nima, Babu, R. Jayachandra

“…A surgically implantable device is an inevitable treatment option for millions of people worldwide suffering from diseases arising from orthopedic injuries. A…”
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Impaired Infarct Healing in Atherosclerotic Mice With Ly-6Chi Monocytosis by Panizzi, Peter, PhD, Swirski, Filip K., PhD, Figueiredo, Jose-Luiz, MD, Waterman, Peter, BS, Sosnovik, David E., MD, Aikawa, Elena, MD, PhD, Libby, Peter, MD, Pittet, Mikael, PhD, Weissleder, Ralph, MD, PhD, Nahrendorf, Matthias, MD, PhD

“…Objectives The aim of this study was to test whether blood monocytosis in mice with atherosclerosis affects infarct healing. Background Monocytes are cellular…”
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Angiotensin II Drives the Production of Tumor-Promoting Macrophages by Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita, Ryan, Russell, Pucci, Ferdinando, Sio, Selena W., Kuswanto, Wilson, Rauch, Philipp J., Chudnovskiy, Aleksey, Iwamoto, Yoshiko, Kohler, Rainer, Marinelli, Brett, Gorbatov, Rostic, Wojtkiewicz, Gregory, Panizzi, Peter, Mino-Kenudson, Mari, Forghani, Reza, Figueiredo, Jose-Luiz, Chen, John W., Xavier, Ramnik, Swirski, Filip K., Nahrendorf, Matthias, Weissleder, Ralph, Pittet, Mikael J.

“…Macrophages frequently infiltrate tumors and can enhance cancer growth, yet the origins of the macrophage response are not well understood. Here we address…”
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Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation by Panizzi, Peter, Nahrendorf, Matthias, Wildgruber, Moritz, Waterman, Peter, Figueiredo, Jose-Luiz, Aikawa, Elena, McCarthy, Jason, Weissleder, Ralph, Hilderbrand, Scott A

“…The current lack of suitable probes has limited the in vivo imaging of reactive oxygen/nitrogen species (ROS/RNS). ROS/RNS are often generated by…”
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In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation by Panizzi, Peter, Nahrendorf, Matthias, Figueiredo, Jose-Luiz, Panizzi, Jennifer, Marinelli, Brett, Iwamoto, Yoshiko, Keliher, Edmund, Maddur, Ashoka A, Waterman, Peter, Kroh, Heather K, Leuschner, Florian, Aikawa, Elena, Swirski, Filip K, Pittet, Mikael J, Hackeng, Tilman M, Fuentes-Prior, Pablo, Schneewind, Olaf, Bock, Paul E, Weissleder, Ralph

“…Infection by coagulase-positive Staphylococcus aureus ( S. aureus ) is the most common cause of acute endocarditis, a destructive and progressive condition of…”
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Co-Delivery of Hispolon and Doxorubicin Liposomes Improves Efficacy Against Melanoma Cells by Al Saqr, Ahmed, Aldawsari, Mohammed F., Alrbyawi, Hamad, Poudel, Ishwor, Annaji, Manjusha, Mulabagal, Vanisree, Ramani, Modukuri V., Gottumukkala, Subbaraju, Tiwari, Amit K., Dhanasekaran, Muralikrishnan, Panizzi, Peter R., Arnold, Robert D., Babu, R. Jayachandra

“…Hispolon is a small molecular weight polyphenol that has antioxidant, anti-inflammatory, and anti-proliferative activities. Our recent study has demonstrated…”
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Sugar Shock: Probing Streptococcus pyogenes Metabolism Through Bioluminescence Imaging by Davis, 4th, Richard W, Muse, Charlotte G, Eggleston, Heather, Hill, Micaila, Panizzi, Peter

“…( ) can thrive in its host during an infection, and, as a result, it must be able to respond to external stimuli and available carbon sources. The preclinical…”
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Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin by Kroh, Heather K, Panizzi, Peter, Bock, Paul E

“…Von Willebrand factor-binding protein (VWbp), secreted by Staphylococcus aureus, displays secondary structural homology to the 3-helix bundle, D1 and D2…”
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Nanoparticle-based probes to enable noninvasive imaging of proteolytic activity for cancer diagnosis by Anani, Tareq, Panizzi, Peter, David, Allan E

“…Proteases play a key role in tumor biology, with high expression levels often correlating with poor prognosis for cancer patients - making them excellent…”
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The Cardioprotective Mechanism of Phenylaminoethyl Selenides (PAESe) Against Doxorubicin-Induced Cardiotoxicity Involves Frataxin by Fu, Xiaoyu, Eggert, Mathew, Yoo, Sieun, Patel, Nikhil, Zhong, Juming, Steinke, Ian, Govindarajulu, Manoj, Turumtay, Emine Akyuz, Mouli, Shravanthi, Panizzi, Peter, Beyers, Ronald, Denney, Thomas, Arnold, Robert, Amin, Rajesh H

“…Doxorubicin (DOX) is an anthracycline cancer chemotherapeutic that exhibits cumulative dose-limiting cardiotoxicity and limits its clinical utility. DOX…”
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Bacillus velezensis AP183 Inhibits Staphylococcus aureus Biofilm Formation and Proliferation in Murine and Bovine Disease Models by Afroj, Sayma, Brannen, Andrew D., Nasrin, Shamima, Al Mouslem, Abdulaziz, Hathcock, Terri, Maxwell, Herris, Rasmussen-Ivey, Cody R., Sandage, Mary J., Davis, Edward W., Panizzi, Peter, Wang, Chengming, Liles, Mark R.

“…The increasing frequency of S. aureus antimicrobial resistance has spurred interest in identifying alternative therapeutants. We investigated the S. aureus-…”
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Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice by Swirski, Filip K, Wildgruber, Moritz, Ueno, Takuya, Figueiredo, Jose-Luiz, Panizzi, Peter, Iwamoto, Yoshiko, Zhang, Elizabeth, Stone, James R, Rodriguez, Elisenda, Chen, John W, Pittet, Mikael J, Weissleder, Ralph, Nahrendorf, Matthias

“…Rates of graft rejection are high among recipients of heart transplants. The onset and progression of clinically significant heart transplant rejection are…”
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Molecular Imaging of Bacterial Infections in vivo: The Discrimination between Infection and Inflammation by Eggleston, Heather, Panizzi, Peter

“…Molecular imaging by definition is the visualization of molecular and cellular processes within a given system. The modalities and reagents described here…”
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Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation by Bode, Wolfram, Bock, Paul E, Friedrich, Rainer, Panizzi, Peter, Fuentes-Prior, Pablo, Richter, Klaus, Verhamme, Ingrid, Anderson, Patricia J, Kawabata, Shun-Ichiro, Huber, Robert

“…Many bacterial pathogens secrete proteins that activate host trypsinogen-like enzyme precursors, most notably the proenzymes of the blood coagulation and…”
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Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear by Berny, Michelle A, Munnix, Imke C A, Auger, Jocelyn M, Schols, Saskia E M, Cosemans, Judith M E M, Panizzi, Peter, Bock, Paul E, Watson, Steve P, McCarty, Owen J T, Heemskerk, Johan W M

“…The generation of thrombin is a critical process in the formation of venous thrombi. In isolated plasma under static conditions, phosphatidylserine…”
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Ratcheting of the Substrate from the Zymogen to Proteinase Conformations Directs the Sequential Cleavage of Prothrombin by Prothrombinase by Bianchini, Elsa P., Orcutt, Steven J., Panizzi, Peter, Bock, Paul E., Krishnaswamy, Sriram, Esmon, Charles T.

“…Prothrombinase catalyzes thrombin formation by the ordered cleavage of two peptide bonds in prothrombin. Although these bonds are likely ≈36 Å apart,…”
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