Search Results - "Panigrahi, Gagan B."

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches by Pinto, Ricardo Mouro, Dragileva, Ella, Kirby, Andrew, Lloret, Alejandro, Lopez, Edith, St Claire, Jason, Panigrahi, Gagan B, Hou, Caixia, Holloway, Kim, Gillis, Tammy, Guide, Jolene R, Cohen, Paula E, Li, Guo-Min, Pearson, Christopher E, Daly, Mark J, Wheeler, Vanessa C

“…The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may…”
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Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability by Reddy, Kaalak, Schmidt, Monika H M, Geist, Jaimie M, Thakkar, Neha P, Panigrahi, Gagan B, Wang, Yuh-Hwa, Pearson, Christopher E

“…R-loops, transcriptionally-induced RNA:DNA hybrids, occurring at repeat tracts (CTG)n, (CAG)n, (CGG)n, (CCG)n and (GAA)n, are associated with diseases…”
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FAN1, a DNA Repair Nuclease, as a Modifier of Repeat Expansion Disorders by Deshmukh, Amit L, Porro, Antonio, Mohiuddin, Mohiuddin, Lanni, Stella, Panigrahi, Gagan B, Caron, Marie-Christine, Masson, Jean-Yves, Sartori, Alessandro A, Pearson, Christopher E

“…FAN1 encodes a DNA repair nuclease. Genetic deficiencies, copy number variants, and single nucleotide variants of FAN1 have been linked to karyomegalic…”
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Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSβ, but clustered slip-outs are poorly repaired by Panigrahi, Gagan B, Slean, Meghan M, Simard, Jodie P, Gileadi, Opher, Pearson, Christopher E

“…Expansions of CTG/CAG trinucleotide repeats, thought to involve slipped DNAs at the repeats, cause numerous diseases including myotonic dystrophy and…”
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Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus by Foiry, Laurent, Pearson, Christopher E, Chitayat, David, Tomé, Stéphanie, Gourdon, Geneviève, Cleary, John D, Hagerman, Katharine A, Sroka, Hana, Panigrahi, Gagan B, López Castel, Arturo

“…Trinucleotide repeat expansions are linked to many diseases, and why there are differences in expansion rates according to tissue type or patient age is…”
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A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo by Nakamori, Masayuki, Panigrahi, Gagan B., Lanni, Stella, Gall-Duncan, Terence, Hayakawa, Hideki, Tanaka, Hana, Luo, Jennifer, Otabe, Takahiro, Li, Jinxing, Sakata, Akihiro, Caron, Marie-Christine, Joshi, Niraj, Prasolava, Tanya, Chiang, Karen, Masson, Jean-Yves, Wold, Marc S., Wang, Xiaoxiao, Lee, Marietta Y. W. T., Huddleston, John, Munson, Katherine M., Davidson, Scott, Layeghifard, Mehdi, Edward, Lisa-Monique, Gallon, Richard, Santibanez-Koref, Mauro, Murata, Asako, Takahashi, Masanori P., Eichler, Evan E., Shlien, Adam, Nakatani, Kazuhiko, Mochizuki, Hideki, Pearson, Christopher E.

“…In many repeat diseases, such as Huntington’s disease (HD), ongoing repeat expansions in affected tissues contribute to disease onset, progression and…”
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Mutagenic roles of DNA “repair” proteins in antibody diversity and disease-associated trinucleotide repeat instability by Slean, Meghan M., Panigrahi, Gagan B., Ranum, Laura P., Pearson, Christopher E.

“…While DNA repair proteins are generally thought to maintain the integrity of the whole genome by correctly repairing mutagenic DNA intermediates, there are…”
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In Vitro (CTG)·(CAG) Expansions and Deletions by Human Cell Extracts by Panigrahi, Gagan B., Cleary, John D., Pearson, Christopher E.

“…The mechanism of disease-associated (CTG)·(CAG) expansion may involve DNA replication slippage, replication direction, Okazaki fragment processing,…”
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Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability by Gall-Duncan, Terence, Luo, Jennifer, Jurkovic, Carla-Marie, Fischer, Laura A., Fujita, Kyota, Deshmukh, Amit L., Harding, Rachel J., Tran, Stephanie, Mehkary, Mustafa, Li, Vanessa, Leib, David E., Chen, Ran, Tanaka, Hikari, Mason, Amanda G., Lévesque, Dominique, Khan, Mahreen, Razzaghi, Mortezaali, Prasolava, Tanya, Lanni, Stella, Sato, Nozomu, Caron, Marie-Christine, Panigrahi, Gagan B., Wang, Peixiang, Lau, Rachel, Castel, Arturo López, Masson, Jean-Yves, Tippett, Lynette, Turner, Clinton, Spies, Maria, La Spada, Albert R., Campos, Eric I., Curtis, Maurice A., Boisvert, François-Michel, Faull, Richard L.M., Davidson, Beverly L., Nakamori, Masayuki, Okazawa, Hitoshi, Wold, Marc S., Pearson, Christopher E.

“…Expansions of repeat DNA tracts cause >70 diseases, and ongoing expansions in brains exacerbate disease. During expansion mutations, single-stranded DNAs…”
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FAN1 exo- not endo-nuclease pausing on disease-associated slipped-DNA repeats: A mechanism of repeat instability by Deshmukh, Amit Laxmikant, Caron, Marie-Christine, Mohiuddin, Mohiuddin, Lanni, Stella, Panigrahi, Gagan B., Khan, Mahreen, Engchuan, Worrawat, Shum, Natalie, Faruqui, Aisha, Wang, Peixiang, Yuen, Ryan K.C., Nakamori, Masayuki, Nakatani, Kazuhiko, Masson, Jean-Yves, Pearson, Christopher E.

“…Ongoing inchworm-like CAG and CGG repeat expansions in brains, arising by aberrant processing of slipped DNAs, may drive Huntington’s disease, fragile X…”
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Functional Repair Assay for the Diagnosis of Constitutional Mismatch Repair Deficiency From Non-Neoplastic Tissue by Shuen, Andrew Y, Lanni, Stella, Panigrahi, Gagan B, Edwards, Melissa, Yu, Lisa, Campbell, Brittany B, Mandel, Ariane, Zhang, Cindy, Zhukova, Nataliya, Alharbi, Musa, Bernstein, Mark, Bowers, Daniel C, Carroll, Sara, Cole, Kristina A, Constantini, Shlomi, Crooks, Bruce, Dvir, Rina, Farah, Roula, Hijiya, Nobuko, George, Ben, Laetsch, Theodore W, Larouche, Valerie, Lindhorst, Scott, Luiten, Rebecca C, Magimairajan, Vanan, Mason, Gary, Mason, Warren, Mordechai, Oz, Mushtaq, Naureen, Nicholas, Garth, Oren, Michael, Palma, Laura, Pedroza, Luis Alberto, Ramdas, Jagadeesh, Samuel, David, Wolfe Schneider, Kami, Seeley, Andrea, Semotiuk, Kara, Shamvil, Ashraf, Sumerauer, David, Toledano, Helen, Tomboc, Patrick, Wierman, Margaret, Van Damme, An, Lee, Yi-Yen, Zapotocky, Michal, Bouffet, Eric, Durno, Carol, Aronson, Melyssa, Gallinger, Steve, Foulkes, William D, Malkin, David, Tabori, Uri, Pearson, Christopher E

“…Constitutional mismatch repair deficiency (CMMRD) is a highly penetrant cancer predisposition syndrome caused by biallelic mutations in mismatch repair (MMR)…”
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Human Mismatch Repair Protein hMutLα Is Required to Repair Short Slipped-DNAs of Trinucleotide Repeats by Panigrahi, Gagan B., Slean, Meghan M., Simard, Jodie P., Pearson, Christopher E.

“…Mismatch repair (MMR) is required for proper maintenance of the genome by protecting against mutations. The mismatch repair system has also been implicated as…”
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Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks by Slean, Meghan M., Panigrahi, Gagan B., Castel, Arturo López, Pearson, August B., Tomkinson, Alan E., Pearson, Christopher E.

“…•Slipped DNAs persist following replication of a contraction biased template in the absence of mismatch repair.•Repair of contraction intermediate slipped DNAs…”
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Slipped (CTG)(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair by Pearson, Christopher E, Panigrahi, Gagan B, Lau, Rachel, Montgomery, S Erin, Leonard, Michelle R

“…Expansion of (CTG)*(CAG) repeats, the cause of 14 or more diseases, is presumed to arise through escaped repair of slipped DNAs. We report the fidelity of…”
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Maternal germline-specific effect of DNA ligase I on CTG/CAG instability by TOME, Stéphanie, PANIGRAHI, Gagan B, LOPEZ CASTEL, Arturo, FOIRY, Laurent, MELTON, David W, GOURDON, Geneviève, PEARSON, Christopher E

“…The instability of (CTG)•(CAG) repeats can cause >15 diseases including myotonic dystrophy, DM1. Instability can arise during DNA replication, repair or…”
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An infant with MLH3 variants, FOXG1-duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study by Kansal, Rina, Li, Xinmin, Shen, Joseph, Samuel, David, Laningham, Fred, Lee, Hane, Panigrahi, Gagan B., Shuen, Andrew, Kantarci, Sibel, Dorrani, Naghmeh, Reiss, Jean, Shintaku, Peter, Deignan, Joshua L., Strom, Samuel P., Pearson, Christopher E., Vilain, Eric, Grody, Wayne W.

“…A 4‐month‐old male infant presented with severe developmental delay, cerebellar, brainstem, and cutaneous hemangiomas, bilateral tumors (vestibular,…”
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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers by Shlien, Adam, Campbell, Brittany B, de Borja, Richard, Alexandrov, Ludmil B, Merico, Daniele, Wedge, David, Van Loo, Peter, Tarpey, Patrick S, Coupland, Paul, Behjati, Sam, Pollett, Aaron, Lipman, Tatiana, Heidari, Abolfazl, Deshmukh, Shriya, Avitzur, Na'ama, Meier, Bettina, Gerstung, Moritz, Hong, Ye, Merino, Diana M, Ramakrishna, Manasa, Remke, Marc, Arnold, Roland, Panigrahi, Gagan B, Thakkar, Neha P, Hodel, Karl P, Henninger, Erin E, Göksenin, A Yasemin, Bakry, Doua, Charames, George S, Druker, Harriet, Lerner-Ellis, Jordan, Mistry, Matthew, Dvir, Rina, Grant, Ronald, Elhasid, Ronit, Farah, Roula, Taylor, Glenn P, Nathan, Paul C, Alexander, Sarah, Ben-Shachar, Shay, Ling, Simon C, Gallinger, Steven, Constantini, Shlomi, Dirks, Peter, Huang, Annie, Scherer, Stephen W, Grundy, Richard G, Durno, Carol, Aronson, Melyssa, Gartner, Anton, Meyn, M Stephen, Taylor, Michael D, Pursell, Zachary F, Pearson, Christopher E, Malkin, David, Futreal, P Andrew, Stratton, Michael R, Bouffet, Eric, Hawkins, Cynthia, Campbell, Peter J, Tabori, Uri

“…Adam Shlien, Peter Campbell, Uri Tabori and colleagues report genome and exome sequencing of biallelic mismatch repair deficiency cancer samples from 12…”
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Absence of MutSbeta leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks by Slean, Meghan M., Panigrahi, Gagan B., Castel, Arturo López, Pearson, August B., Tomkinson, Alan E., Pearson, Christopher E.

“…Typically disease-causing CAG/CTG repeats expand, but rare affected families can display high levels of contraction of the expanded repeat amongst offspring…”
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Syntheses of oligonucleotide-amino acid conjugates: Using TentaGel and CPG matrices for the synthesis of 3′-phosphoryltyrosine-terminated oligonucleotides by Zhao, Bao Ping, Panigrahi, Gagan B, Sadowski, Paul D, Krepinsky, Jiri J

“…3′-Phosphoryl-O-tyrosine terminated oligonucleotides were synthesized using controlled-pore glass (CPG) and TentaGel solid matrices. For the synthesis on CPG,…”
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An infant with MLH 3 variants, FOXG 1 ‐duplication and multiple, benign cranial and spinal tumors: A clinical exome sequencing study by Kansal, Rina, Li, Xinmin, Shen, Joseph, Samuel, David, Laningham, Fred, Lee, Hane, Panigrahi, Gagan B., Shuen, Andrew, Kantarci, Sibel, Dorrani, Naghmeh, Reiss, Jean, Shintaku, Peter, Deignan, Joshua L., Strom, Samuel P., Pearson, Christopher E., Vilain, Eric, Grody, Wayne W.

“…A 4‐month‐old male infant presented with severe developmental delay, cerebellar, brainstem, and cutaneous hemangiomas, bilateral tumors (vestibular,…”
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