Search Results - "Panieri, Emiliano"

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation by Saha, Sarmistha, Buttari, Brigitta, Panieri, Emiliano, Profumo, Elisabetta, Saso, Luciano

“…Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer's disease, and many others, and the current state of available…”
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Potential Applications of NRF2 Inhibitors in Cancer Therapy by Panieri, Emiliano, Saso, Luciano

“…The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms against exogenous or endogenous stressors. Indeed, by increasing the…”
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PFAS Molecules: A Major Concern for the Human Health and the Environment by Panieri, Emiliano, Baralic, Katarina, Djukic-Cosic, Danijela, Buha Djordjevic, Aleksandra, Saso, Luciano

“…Per- and polyfluoroalkyl substances (PFAS) are a group of over 4700 heterogeneous compounds with amphipathic properties and exceptional stability to chemical…”
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Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer by Telkoparan-Akillilar, Pelin, Panieri, Emiliano, Cevik, Dilek, Suzen, Sibel, Saso, Luciano

“…Cancer is one of the most fatal diseases with an increasing incidence and mortality all over the world. Thus, there is an urgent need for novel therapies…”
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The Interaction of Flavonols with Membrane Components: Potential Effect on Antioxidant Activity by Saha, Sarmistha, Panieri, Emiliano, Suzen, Sibel, Saso, Luciano

“…Flavonols are the most widely distributed class of dietary flavonoids with a wide range of pharmacological properties due to their potent lipid peroxidation…”
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Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury by Lillo-Moya, José, Rojas-Solé, Catalina, Muñoz-Salamanca, Diego, Panieri, Emiliano, Saso, Luciano, Rodrigo, Ramón

“…Ischemic heart disease is a leading cause of death worldwide. Primarily, ischemia causes decreased oxygen supply, resulting in damage of the cardiac tissue…”
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The NRF2/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives by Panieri, Emiliano, Telkoparan-Akillilar, Pelin, Suzen, Sibel, Saso, Luciano

“…The NRF2/KEAP1 pathway is a fundamental signaling cascade that controls multiple cytoprotective responses through the induction of a complex transcriptional…”
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Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process by Süntar, Ipek, Çetinkaya, Sümeyra, Panieri, Emiliano, Saha, Sarmistha, Buttari, Brigitta, Profumo, Elisabetta, Saso, Luciano

“…Wound healing involves a series of cellular events in damaged cells and tissues initiated with hemostasis and finally culminating with the formation of a…”
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Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin by Tascioglu Aliyev, Alev, Panieri, Emiliano, Stepanić, Višnja, Gurer-Orhan, Hande, Saso, Luciano

“…Oxidative stress is defined as a disturbance in the prooxidant/antioxidant balance in favor of the former and a loss of control over redox signaling processes,…”
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Potential Applications of NRF2 Modulators in Cancer Therapy by Panieri, Emiliano, Buha, Aleksandra, Telkoparan-Akillilar, Pelin, Cevik, Dilek, Kouretas, Demetrios, Veskoukis, Aristidis, Skaperda, Zoi, Tsatsakis, Aristidis, Wallace, David, Suzen, Sibel, Saso, Luciano

“…The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) regulatory pathway plays an essential role in protecting…”
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Joint Cardioprotective Effect of Vitamin C and Other Antioxidants against Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention by Rodrigo, Ramón, Prieto, Juan Carlos, Aguayo, Rubén, Ramos, Cristóbal, Puentes, Ángel, Gajardo, Abraham, Panieri, Emiliano, Rojas-Solé, Catalina, Lillo-Moya, José, Saso, Luciano

“…Percutaneous coronary intervention (PCI) has long remained the gold standard therapy to restore coronary blood flow after acute myocardial infarction (AMI)…”
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PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis by Mana, Giulia, Clapero, Fabiana, Panieri, Emiliano, Panero, Valentina, Böttcher, Ralph T., Tseng, Hui-Yuan, Saltarin, Federico, Astanina, Elena, Wolanska, Katarzyna I., Morgan, Mark R., Humphries, Martin J., Santoro, Massimo M., Serini, Guido, Valdembri, Donatella

“…Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell (EC) polarity and vascular remodelling. However, mechanisms…”
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The Role of Toxic Metals and Metalloids in Nrf2 Signaling by Buha, Aleksandra, Baralić, Katarina, Djukic-Cosic, Danijela, Bulat, Zorica, Tinkov, Alexey, Panieri, Emiliano, Saso, Luciano

“…Nuclear factor erythroid 2-related factor 2 (Nrf2), an emerging regulator of cellular resistance to oxidants, serves as one of the key defensive factors…”
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NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells by Panieri, Emiliano, Pinho, Sónia A., Afonso, Gonçalo J. M., Oliveira, Paulo J., Cunha-Oliveira, Teresa, Saso, Luciano

“…The NRF2–KEAP1 system is a fundamental component of the cellular response that controls a great variety of transcriptional targets that are mainly involved in…”
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Endocrine disruption by PFAS: A major concern associated with legacy and replacement substances by Panieri, Emiliano, Buha-Đorđevic, Aleksandra, Saso, Luciano

“…Perand poly-fluorinated alkyl substances (PFAS) have been used for decades in a great variety of processes and products by virtue of their exceptional…”
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Nitro-Oxidative Stress and Mitochondrial Dysfunction in Human Cell Lines Exposed to the Environmental Contaminants PFOA and BPA by Magnifico, Maria Chiara, Xhani, Marla, Sprovera, Benedetta, Buttari, Brigitta, Abballe, Giorgia, Desideri, Flaminia, Panieri, Emiliano, Saso, Luciano, Arese, Marzia

“…Bisphenol A (BPA) and perfluorooctanoic acid (PFOA) are synthetic compounds widely utilized in industrial activities devoted to the production of daily life…”
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Data on metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions by Panieri, Emiliano, Santoro, Massimo M.

“…In this article we used transgenic zebrafish lines that express compartment-specific isoforms of the roGFP2-Orp1 and Grx1-roGFP2 biosensors, described in…”
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Inhibition of the NRF2/KEAP1 Axis: A Promising Therapeutic Strategy to Alter Redox Balance of Cancer Cells by Panieri, Emiliano, Saso, Luciano

“…The nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (NRF2/KEAP1) pathway is a crucial and highly conserved defensive system…”
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Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage by Panieri, Emiliano, Toietta, Gabriele, Mele, Marina, Labate, Valentina, Ranieri, Sofia Chiatamone, Fusco, Salvatore, Tesori, Valentina, Antonini, Annalisa, Maulucci, Giuseppe, De Spirito, Marco, Galeotti, Tommaso, Pani, Giovambattista

“…Deregulated nutrient signaling plays pivotal roles in body ageing and in diabetic complications; biochemical cascades linking energy dysmetabolism to cell…”
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Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance by Ranieri, Sofia Chiatamone, Fusco, Salvatore, Panieri, Emiliano, Labate, Valentina, Mele, Marina, Tesori, Valentina, Ferrara, Anna Maria, Maulucci, Giuseppe, De Spirito, Marco, Martorana, Giuseppe Ettore, Galeotti, Tommaso, Pani, Giovambattista

“…Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes and accelerated…”
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