Search Results - "Panicker, Sumith R"

Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells by Giri, Hemant, Panicker, Sumith R., Cai, Xiaofeng, Biswas, Indranil, Weiler, Hartmut, Rezaie, Alireza R.

“…Thrombomodulin (TM) is a thrombin receptor on endothelial cells that is involved in promoting activation of the anticoagulant protein C pathway during blood…”
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Inorganic Polyphosphate Amplifies High Mobility Group Box 1–Mediated Von Willebrand Factor Release and Platelet String Formation on Endothelial Cells by Biswas, Indranil, Panicker, Sumith R, Cai, Xiaofeng, Mehta-D’souza, Padmaja, Rezaie, Alireza R

“…OBJECTIVE—Inorganic polyphosphate (polyP) is known to modulate coagulation, inflammation, and metabolic pathways. It also amplifies inflammatory responses of…”
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Activated protein C inhibits lipopolysaccharide‐mediated acetylation and secretion of high‐mobility group box 1 in endothelial cells by Cai, Xiaofeng, Biswas, Indranil, Panicker, Sumith R., Giri, Hemant, Rezaie, Alireza R.

“…Essentials APC elicits cytoprotective responses in endothelial cells via EPCR‐dependent cleavage of PAR1. APC inhibits LPS‐mediated translocation and…”
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Extracellular Histones Bind Vascular Glycosaminoglycans and Inhibit the Anti-Inflammatory Function of Antithrombin by Biswas, Indranil, Panicker, Sumith R, Cai, Xiaofeng S, Giri, Hemant, Rezaie, Alireza R

“…Binding of histones to molecular pattern recognition receptors on endothelial cells and leukocytes provokes proinflammatory responses and promotes activation…”
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L-selectin mechanochemistry restricts neutrophil priming in vivo by Liu, Zhenghui, Yago, Tadayuki, Zhang, Nan, Panicker, Sumith R., Wang, Ying, Yao, Longbiao, Mehta-D’souza, Padmaja, Xia, Lijun, Zhu, Cheng, McEver, Rodger P.

“…Circulating neutrophils must avoid premature activation to prevent tissue injury. The leukocyte adhesion receptor L-selectin forms bonds with P-selectin…”
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Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force by Mehta-D'souza, Padmaja, Klopocki, Arkadiusz G., Oganesyan, Vaheh, Terzyan, Simon, Mather, Timothy, Li, Zhenhai, Panicker, Sumith R., Zhu, Cheng, McEver, Rodger P.

“…Selectin interactions with fucosylated glycan ligands mediate leukocyte rolling in the vasculature under shear forces. Crystal structures of P- and E-selectin…”
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Thrombomodulin Regulation of Mitogen-Activated Protein Kinases by Giri, Hemant, Cai, Xiaofeng, Panicker, Sumith R, Biswas, Indranil, Rezaie, Alireza R

“…The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection,…”
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Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength by Panicker, Sumith R., Yago, Tadayuki, Shao, Bojing, McEver, Rodger P.

“…Ezrin/radixin/moesin (ERM) proteins are adaptors that link the actin cytoskeleton to the cytoplasmic domains of membrane proteins. Leukocytes express mostly…”
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Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin by Biswas, Indranil, Giri, Hemant, Panicker, Sumith R, Rezaie, Alireza R

“…Cleavage of the extracellular domain of PAR1 (protease-activated receptor 1) by thrombin at Arg41 and by APC (activated protein C) at Arg46 initiates…”
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Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice by Panicker, Sumith R., Mehta-D'souza, Padmaja, Zhang, Nan, Klopocki, Arkadiusz G., Shao, Bojing, McEver, Rodger P.

“…Leukocyte adhesion to P-selectin on activated platelets and endothelial cells induces shedding of the P-selectin ectodomain into the circulation. Plasma…”
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Protective Role of Activated Protein C against Viral Mimetic Poly(I:C)-Induced Inflammation by Cai, Xiaofeng, Panicker, Sumith R, Biswas, Indranil, Giri, Hemant, Rezaie, Alireza R

“…Activated protein C (APC) is an anticoagulant plasma serine protease which exhibits potent cytoprotective and anti-inflammatory activities. Here, we studied…”
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PKC (Protein Kinase C)-δ Modulates AT (Antithrombin) Signaling in Vascular Endothelial Cells by Panicker, Sumith R., Biswas, Indranil, Giri, Hemant, Cai, Xiaofeng, Rezaie, Alireza R.

“…OBJECTIVE:Native and latent conformers of AT (antithrombin) induce anti-inflammatory and proapoptotic signaling activities, respectively, in vascular…”
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Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice by Shi, Huiping, Song, Jianhua, Gao, Liang, Shan, Xindi, Panicker, Sumith R, Yao, Longbiao, McDaniel, Michael, Zhou, Meixiang, McGee, Samuel, Zhong, Hui, Griffin, Courtney T, Xia, Lijun, Shao, Bojing

“…Integrin-regulated monocyte recruitment and cellular responses of monocyte-derived macrophages are critical for the pathogenesis of atherosclerosis. In the…”
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Th1 Cells Rolling on Selectins Trigger DAP12-Dependent Signals That Activate Integrin αLβ2 by Shao, Bojing, Yago, Tadayuki, Panicker, Sumith R, Zhang, Nan, Liu, Zhenghui, McEver, Rodger P

“…During inflammation, both neutrophils and effector T cells use selectins to roll and integrins to arrest in postcapillary venules. In both cell types,…”
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Venous and arterial thrombosis in patients with VEXAS syndrome by Kusne, Yael, Ghorbanzadeh, Atefeh, Dulau-Florea, Alina, Shalhoub, Ruba, Alcedo, Pedro E., Nghiem, Khanh, Ferrada, Marcela A., Hines, Alexander, Quinn, Kaitlin A., Panicker, Sumith R., Ombrello, Amanda K., Reichard, Kaaren, Darden, Ivana, Goodspeed, Wendy, Durrani, Jibran, Wilson, Lorena, Olteanu, Horatiu, Lasho, Terra, Kastner, Daniel L., Warrington, Kenneth J., Mangaonkar, Abhishek, Go, Ronald S., Braylan, Raul C., Beck, David B., Patnaik, Mrinal M., Young, Neal S., Calvo, Katherine R., Casanegra, Ana I., Grayson, Peter C., Koster, Matthew J., Wu, Colin O., Kanthi, Yogendra, Patel, Bhavisha A., Houghton, Damon E., Groarke, Emma M.

“…•VTE is common in VEXAS syndrome, occurring in over 40% of patients with frequent recurrences; however, it is not associated with increased mortality.•Given…”
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Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice by Liu, Zhenghui, Zhang, Nan, Shao, Bojing, Panicker, Sumith R., Fu, Jianxin, McEver, Rodger P.

“…In humans and mice, megakaryocytes/platelets and endothelial cells constitutively synthesize P-selectin and mobilize it to the plasma membrane to mediate…”
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Antithrombin protects against Plasmodium falciparum histidine-rich protein II-mediated inflammation and coagulation by Biswas, Indranil, Panicker, Sumith R., Giri, Hemant, Cai, Xiaofeng S., Rezaie, Alireza R.

“…Plasmodium falciparum-derived histidine-rich protein II (HRPII) has been shown to inhibit heparin-dependent anticoagulant activity of antithrombin (AT) and…”
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Association of monocyte chemoattractant protein-1 -2518 polymorphism with metabolic syndrome in a South Indian cohort by Kaur, Savneet, Panicker, Sumith R, James, T, Sarma, P Sankara, Thankappan, K R, Kartha, Chandrasekharan C

“…Previous reports have indicated an association of monocyte chemoattractant protein-1 (MCP-1) with risk factors for atherosclerosis and coronary artery disease…”
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Protein kinase C-δ modulates antithrombin signaling in vascular endothelial cells by Panicker, Sumith R., Biswas, Indranil, Giri, Hemant, Cai, Xiaofeng, Rezaie, Alireza R.

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Activated protein C inhibits LPS-mediated acetylation and secretion of HMGB1 in endothelial cells by Cai, Xiaofeng, Biswas, Indranil, Panicker, Sumith R., Giri, Hemant, Rezaie, Alireza R.

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