The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review

The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review

Ovarian cancer is a frequent malignancy that affects a large percentage of women. Endometriosis is a chronic condition, where there is a production of benign lesions were observed in the uterine environment. PCOS is a metabolic disorder characterized by the presence of numerous cysts in the ovaries....

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Bibliographic Details
Published in:Critical reviews in oncology/hematology Vol. 180; p. 103852
Main Authors: Throwba, Harinee, Unnikrishnan, Lakshmi, Pangath, Meghna, Vasudevan, Karthick, Jayaraman, Selvaraj, Li, Min, Iyaswamy, Ashok, Palaniyandi, Kanagaraj, Gnanasampanthapandian, Dhanavathy
Format: Journal Article
Language:English
Published: Elsevier B.V 01-12-2022
Subjects:
Endometriosis
Epigenetics
Metastasis
Ovarian cancer
PCOS
Epigenetics
Endometriosis
PCOS
Metastasis
Ovarian cancer
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Summary:Ovarian cancer is a frequent malignancy that affects a large percentage of women. Endometriosis is a chronic condition, where there is a production of benign lesions were observed in the uterine environment. PCOS is a metabolic disorder characterized by the presence of numerous cysts in the ovaries. The relation between ovarian malignancies and PCOS, by an increased ratio of ovarian stromal tissues in PCOS patients. The direct correlation is not yet confirmed among the three disorders, but it is often noted that they share risk factors, such as obesity, hormonal imbalances. Epigenetic factors have shown to be an important reason for cancer progression. Our findings at the epigenetic level includes a comparative analysis, point mutations in genes, overactivation of signaling pathways. This review paper, highlight the possible correlation between the three disorders in terms of genetic and epigenetic factors and how it could together trigger the cancer progression and metastasis. [Display omitted] •Epigenetic regulation of ovarian cancer, endometriosis and PCOS.•Biomarkers in ovarian and endometrial cancer.•Genetic mutations that cause ovarian cancer and endometrial cancer.•Potential risk factors for PCOS, endometrial cancer and ovarian cancer.•Role of non-coding RNA in PCOS, endometrial cancer and ovarian cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2022.103852