Search Results - "Pangalos, MN"

Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and GPRC5C) by Robbins, M.J., Michalovich, D., Hill, J., Calver, A.R., Medhurst, A.D., Gloger, I., Sims, M., Middlemiss, D.N., Pangalos, M.N.

“…Using homology searching of public databases with a metabotropic glutamate receptor sequence from Caenorhabditis elegans, two novel protein sequences (named…”
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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework by Cook, David, Brown, Dearg, Alexander, Robert, March, Ruth, Morgan, Paul, Satterthwaite, Gemma, Pangalos, Menelas N.

“…Pangalos and colleagues discuss the results of a comprehensive longitudinal review of AstraZeneca's small-molecule drug projects from 2005 to 2010. They…”
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Impact of a five-dimensional framework on R&D productivity at AstraZeneca by Morgan, Paul, Brown, Dean G., Lennard, Simon, Anderton, Mark J., Barrett, J. Carl, Eriksson, Ulf, Fidock, Mark, Hamrén, Bengt, Johnson, Anthony, March, Ruth E., Matcham, James, Mettetal, Jerome, Nicholls, David J., Platz, Stefan, Rees, Steve, Snowden, Michael A., Pangalos, Menelas N.

“…In 2011, AstraZeneca set out to improve its research and development (R&D) productivity by focusing decision-making using a framework with five technical…”
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Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting by Anttila, Vesa, Saraste, Antti, Knuuti, Juhani, Hedman, Marja, Jaakkola, Pekka, Laugwitz, Karl-Ludwig, Krane, Markus, Jeppsson, Anders, Sillanmäki, Saara, Rosenmeier, Jaya, Zingmark, Pernilla, Rudvik, Anna, Garkaviy, Pavlo, Watson, Christina, Pangalos, Menelas N., Chien, Kenneth R., Fritsche-Danielson, Regina, Collén, Anna, Gan, Li-Ming

“…Vascular endothelial growth factor A (VEGF-A) has therapeutic cardiovascular effects, but delivery challenges have impeded clinical development. We report the…”
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Rapamycin alleviates toxicity of different aggregate-prone proteins by Berger, Zdenek, Ravikumar, Brinda, Menzies, Fiona M., Oroz, Lourdes Garcia, Underwood, Benjamin R., Pangalos, Menelas N., Schmitt, Ina, Wullner, Ullrich, Evert, Bernd O., O'Kane, Cahir J., Rubinsztein, David C.

“…Many neurodegenerative diseases are caused by intracellular, aggregate-prone proteins, including polyglutamine-expanded huntingtin in Huntington's disease (HD)…”
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Early-Onset Behavioral and Synaptic Deficits in a Mouse Model of Alzheimer's Disease by Jacobsen, J. Steven, Wu, Chi-Cheng, Redwine, Jeffrey M., Comery, Thomas A., Arias, Robert, Bowlby, Mark, Martone, Robert, Morrison, John H., Pangalos, Menelas N., Reinhart, Peter H., Bloom, Floyd E.

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which numerous mouse models have been generated. In both AD patients and mouse models,…”
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Methamphetamine-Evoked Depression of GABAB Receptor Signaling in GABA Neurons of the VTA by Padgett, Claire L., Lalive, Arnaud L., Tan, Kelly R., Terunuma, Miho, Munoz, Michaelanne B., Pangalos, Menelas N., Martínez-Hernández, José, Watanabe, Masahiko, Moss, Stephen J., Luján, Rafael, Lüscher, Christian, Slesinger, Paul A.

“…Psychostimulants induce neuroadaptations in excitatory and fast inhibitory transmission in the ventral tegmental area (VTA). Mechanisms underlying drug-evoked…”
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Localisation of the GPRC5B receptor in the rat brain and spinal cord by Robbins, Melanie J, Charles, Kelly J, Harrison, David C, Pangalos, Menelas N

“…Recently a novel subfamily of closely related orphan G protein-coupled receptors (GPCRs) was identified, called GPRC5A, GPRC5B, GPRC5C and GPRC5D. Based on…”
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Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival by Jaillard, C, Harrison, S, Stankoff, B, Aigrot, M. S, Calver, A. R, Duddy, G, Walsh, F. S, Pangalos, M. N, Arimura, N, Kaibuchi, K, Zalc, B, Lubetzki, C

“…Endothelial differentiation gene (Edg) proteins are G-protein-coupled receptors activated by lysophospholipid mediators: sphingosine-1-phosphate (S1P) or…”
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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease by Comery, Thomas A, Martone, Robert L, Aschmies, Suzan, Atchison, Kevin P, Diamantidis, George, Gong, Xiaohai, Zhou, Hua, Kreft, Anthony F, Pangalos, Menelas N, Sonnenberg-Reines, June, Jacobsen, J Steven, Marquis, Karen L

“…Transgenic mice (Tg2576) overexpressing the Swedish mutation of the human amyloid precursor protein display biochemical, pathological, and behavioral markers…”
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Phospho-dependent binding of the clathrin AP2 adaptor complex to GABA A receptors regulates the efficacy of inhibitory synaptic transmission by Kittler, Josef T., Chen, Guojun, Honing, Stephan, Bogdanov, Yury, McAinsh, Kristina, Arancibia-Carcamo, I. Lorena, Jovanovic, Jasmina N., Pangalos, Menelas N., Haucke, Volker, Yan, Zhen, Moss, Stephen J.

“…The efficacy of synaptic inhibition depends on the number of γ-aminobutyric acid type A receptors (GABA A Rs) expressed on the cell surface of neurons. The…”
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GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer by Robbins, M J, Calver, A R, Filippov, A K, Hirst, W D, Russell, R B, Wood, M D, Nasir, S, Couve, A, Brown, D A, Moss, S J, Pangalos, M N

“…GABA(B) receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement for heterodimerization between two homologous subunits, GABA(B1)…”
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Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice by Prosser, H M, Gill, C H, Hirst, W D, Grau, E, Robbins, M, Calver, A, Soffin, E M, Farmer, C E, Lanneau, C, Gray, J, Schenck, E, Warmerdam, B S, Clapham, C, Reavill, C, Rogers, D C, Stean, T, Upton, N, Humphreys, K, Randall, A, Geppert, M, Davies, C H, Pangalos, M N

“…The recent cloning of two GABA(B) receptor subunits, GABA(B1) and GABA(B2), has raised the possibility that differences in GABA(B) receptor subunit composition…”
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The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models by Medhurst, Andrew D, Harrison, David C, Read, Simon J, Campbell, Colin A, Robbins, Melanie J, Pangalos, Menelas N

“…TaqMan reverse transcription polymerase chain reaction (RT-PCR) is a recently developed technique which allows the measurement of an accumulating PCR product…”
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Cyclic AMP-dependent protein kinase phosphorylation facilitates GABA(B) receptor-effector coupling by Couve, A, Thomas, P, Calver, A R, Hirst, W D, Pangalos, M N, Walsh, F S, Smart, T G, Moss, S J

“…GABA (gamma-aminobutyric acid)(B) receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system…”
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The C-terminal domains of the GABA(b) receptor subunits mediate intracellular trafficking but are not required for receptor signaling by Calver, A R, Robbins, M J, Cosio, C, Rice, S Q, Babbs, A J, Hirst, W D, Boyfield, I, Wood, M D, Russell, R B, Price, G W, Couve, A, Moss, S J, Pangalos, M N

“…GABA(B) receptors are G-protein-coupled receptors that mediate slow synaptic inhibition in the brain and spinal cord. These receptors are heterodimers…”
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Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide by Pangalos, M N, Jacobsen, S J, Reinhart, P H

“…AD (Alzheimer's disease) is characterized neuropathologically by the presence of amyloid plaques, neurofibrillary tangles and profound grey matter loss. The…”
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Comparative immunohistochemical localisation of GABA(B1a), GABA(B1b) and GABA(B2) subunits in rat brain, spinal cord and dorsal root ganglion by Charles, K J, Evans, M L, Robbins, M J, Calver, A R, Leslie, R A, Pangalos, M N

“…GABA(B) receptors are G-protein-coupled receptors mediating the slow onset and prolonged synaptic actions of GABA in the CNS. The recent cloning of two genes,…”
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GABA(B) receptors: from monogamy to promiscuity by Calver, A R, Davies, C H, Pangalos, M

“…The aim of this review is firstly to describe the current understanding of the diverse physiology and pharmacology of GABA(B) receptors in vivo. We will then…”
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Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca2+ Influx by Riccio, Antonio, Mattei, Cesar, Kelsell, Rosemary E., Medhurst, Andrew D., Calver, Andrew R., Randall, Andrew D., Davis, John B., Benham, Christopher D., Pangalos, Menelas N.

“…The regulation and control of plasma membrane Ca2+ fluxes is critical for the initiation and maintenance of a variety of signal transduction cascades…”
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