Search Results - "Pang, Xiaming"

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS by McMahon, Mary, Contreras, Adrian, Holm, Mikael, Uechi, Tamayo, Forester, Craig M, Pang, Xiaming, Jackson, Cody, Calvert, Meredith E, Chen, Bin, Quigley, David A, Luk, John M, Kelley, R Kate, Gordan, John D, Gill, Ryan M, Blanchard, Scott C, Ruggero, Davide

“…Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily…”
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Discovery of Lysine-Targeted eIF4E Inhibitors through Covalent Docking by Wan, Xiaobo, Yang, Tangpo, Cuesta, Adolfo, Pang, Xiaming, Balius, Trent E, Irwin, John J, Shoichet, Brian K, Taunton, Jack

“…Eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP cap structure at the 5′-end of mRNAs, stimulating the translation of proteins implicated in…”
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The Carboxyl-terminal Tail of Noxa Protein Regulates the Stability of Noxa and Mcl-1 by Pang, Xiaming, Zhang, Jingjing, Lopez, Hernando, Wang, Yushu, Li, Wenyang, O'Neill, Katelyn L., Evans, Jacquelynn J.D., George, Nicholas M., Long, Jianhong, Chen, Yi, Luo, Xu

“…The BH3-only protein Noxa is a critical mediator of apoptosis and functions primarily by sequestering/inactivating the antiapoptotic Bcl-2 family protein…”
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Perturbation of the Bcl-2 Network and an Induced Noxa/Bcl-xL Interaction Trigger Mitochondrial Dysfunction after DNA Damage by Lopez, Hernando, Zhang, Liqiang, George, Nicholas M., Liu, Xiaoqiong, Pang, Xiaming, Evans, Jacquelynn J.D., Targy, Natalie M., Luo, Xu

“…How most apoptotic stimuli trigger mitochondrial dysfunction remains to be resolved. We screened the entire Bcl-2 network for its involvement in DNA…”
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Differential Requirements for eIF4E Dose in Normal Development and Cancer by Truitt, Morgan L., Conn, Crystal S., Shi, Zhen, Pang, Xiaming, Tokuyasu, Taku, Coady, Alison M., Seo, Youngho, Barna, Maria, Ruggero, Davide

“…eIF4E, the major cap-binding protein, has long been considered limiting for translating the mammalian genome. However, the eIF4E dose requirement at an…”
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BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis by Huang, Kai, O’Neill, Katelyn L., Li, Jian, Zhou, Wei, Han, Na, Pang, Xiaming, Wu, Wei, Struble, Lucas, Borgstahl, Gloria, Liu, Zhaorui, Zhang, Liqiang, Luo, Xu

“…It has been widely accepted that mitochondria-dependent apoptosis initiates when select BH3-only proteins (BID, BIM, etc.) directly engage and allosterically…”
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The methyltransferase PRMT1 regulates γ-globin translation by Wang, Ying, Li, Xinyu, Ge, Jingru, Liu, Ming, Pang, Xiaming, Liu, Jianpeng, Luo, Cheng, Xu, Yichen, Zhao, Quan

“…Induction of fetal hemoglobin to overcome adult β-globin gene deficiency is an effective therapeutic strategy to ameliorate human β-hemoglobinopathies…”
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Regulation of eIF4E guides a unique translational program to control erythroid maturation by Forester, Craig M, Oses-Prieto, Juan A, Phillips, Nancy J, Miglani, Sohit, Pang, Xiaming, Byeon, Gun Woo, DeMarco, Rachel, Burlingame, Al, Barna, Maria, Ruggero, Davide

“…Translation control is essential in balancing hematopoietic precursors and differentiation; however, the mechanisms underlying this program are poorly…”
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Active Bax and Bak are functional holins by Pang, Xiaming, Moussa, Samir H, Targy, Natalie M, Bose, Jeffrey L, George, Nicholas M, Gries, Casey, Lopez, Hernando, Zhang, Liqiang, Bayles, Kenneth W, Young, Ry, Luo, Xu

“…The mechanism of Bax/Bak-dependent mitochondrial outer membrane permeabilization (MOMP), a central apoptotic event primarily controlled by the Bcl-2 family…”
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Mechanistic studies of mitochondrial outer membrane permeabilization (MOMP) by Pang, Xiaming

“…The mechanism of Bax/Bak-dependent mitochondrial outer membrane permeabilization (MOMP), a central apoptotic event primarily controlled by the Bcl-2 family…”
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