Search Results - "Panetta, John C."

Methotrexate-Induced Neurotoxicity and Leukoencephalopathy in Childhood Acute Lymphoblastic Leukemia by BHOJWANI, Deepa, SABIN, Noah D, HOWARD, Scott C, RIBEIRO, Raul C, CHENG CHENG, REDDICK, Wilburn E, JEHA, Sima, SANDLUND, John T, EVANS, William E, PUI, Ching-Hon, RELLING, Mary V, DEQING PEI, YANG, Jun J, KHAN, Raja B, PANETTA, John C, KRULL, Kevin R, INABA, Hiroto, RUBNITZ, Jeffrey E, METZGER, Monika L

“…Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and…”
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Antibodies Predict Pegaspargase Allergic Reactions and Failure of Rechallenge by Liu, Yiwei, Smith, Colton A, Panetta, John C, Yang, Wenjian, Thompson, Lauren E, Counts, Jacob P, Molinelli, Alejandro R, Pei, Deqing, Kornegay, Nancy M, Crews, Kristine R, Swanson, Hope, Cheng, Cheng, Karol, Seth E, Evans, William E, Inaba, Hiroto, Pui, Ching-Hon, Jeha, Sima, Relling, Mary V

“…Pegaspargase (PEG-ASP) has largely replaced native asparaginase (L-ASP) in the treatment of acute lymphoblastic leukemia because of its longer half-life and…”
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Changes in body mass index, height, and weight in children during and after therapy for acute lymphoblastic leukemia by Browne, Emily K., Zhou, Yinmei, Chemaitilly, Wassim, Panetta, John C., Ness, Kirsten K., Kaste, Sue C., Cheng, Cheng, Relling, Mary V., Pui, Ching‐Hon, Inaba, Hiroto

“…Background Children with acute lymphoblastic leukemia (ALL) have an increased risk of obesity and short stature. To the authors’ knowledge, data regarding…”
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Genome-wide study of methotrexate clearance replicates SLCO1B1 by Ramsey, Laura B., Panetta, John C., Smith, Colton, Yang, Wenjian, Fan, Yiping, Winick, Naomi J., Martin, Paul L., Cheng, Cheng, Devidas, Meenakshi, Pui, Ching-Hon, Evans, William E., Hunger, Stephen P., Loh, Mignon, Relling, Mary V.

“…Methotrexate clearance can influence the cure of and toxicity in children with acute lymphoblastic leukemia (ALL). We estimated methotrexate plasma clearance…”
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Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects by Treviño, Lisa R, Shimasaki, Noriko, Yang, Wenjian, Panetta, John C, Cheng, Cheng, Pei, Deqing, Chan, Diana, Sparreboom, Alex, Giacomini, Kathleen M, Pui, Ching-Hon, Evans, William E, Relling, Mary V

“…Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate…”
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Hepatocellular Shuttling and Recirculation of Sorafenib-Glucuronide Is Dependent on Abcc2, Abcc3, and Oatp1a/1b by Vasilyeva, Aksana, Durmus, Selvi, Li, Lie, Wagenaar, Els, Hu, Shuiying, Gibson, Alice A, Panetta, John C, Mani, Sridhar, Sparreboom, Alex, Baker, Sharyn D, Schinkel, Alfred H

“…Recently, an efficient liver detoxification process dubbed "hepatocyte hopping" was proposed on the basis of findings with the endogenous compound, bilirubin…”
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Genetic predictors of interindividual variability in hepatic CYP3A4 expression by Lamba, Vishal, Panetta, John C, Strom, Stephen, Schuetz, Erin G

“…Variability in hepatic CYP3A4 cannot be explained by common CYP3A4 coding variants. We previously identified polymorphisms in pregnane X receptor (PXR) and…”
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MicroRNAs Form Triplexes with Double Stranded DNA at Sequence-Specific Binding Sites; a Eukaryotic Mechanism via which microRNAs Could Directly Alter Gene Expression by Paugh, Steven W, Coss, David R, Bao, Ju, Laudermilk, Lucas T, Grace, Christy R, Ferreira, Antonio M, Waddell, M Brett, Ridout, Granger, Naeve, Deanna, Leuze, Michael, LoCascio, Philip F, Panetta, John C, Wilkinson, Mark R, Pui, Ching-Hon, Naeve, Clayton W, Uberbacher, Edward C, Bonten, Erik J, Evans, William E

“…MicroRNAs are important regulators of gene expression, acting primarily by binding to sequence-specific locations on already transcribed messenger RNAs (mRNA)…”
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Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy by Karol, Seth E, Pei, Deqing, Smith, Colton A, Liu, Yiwei, Yang, Wenjian, Kornegay, Nancy M, Panetta, John C, Crews, Kristine R, Cheng, Cheng, Finch, Emily R, Inaba, Hiroto, Metzger, Monika L, Rubnitz, Jeffrey E, Ribeiro, Raul C, Gruber, Tanja A, Yang, Jun J, Evans, William E, Jeha, Sima, Pui, Ching-Hon, Relling, Mary V

“…Chemotherapy dosages are often compromised, but most reports lack data on dosages that are actually delivered. In two consecutive acute lymphoblastic leukemia…”
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The Combination of Predictive Factors of Pharmacokinetic Origin Associates with Enhanced Disease Control during Treatment of Pediatric Crohn's Disease with Infliximab by Dubinsky, Marla C, Rabizadeh, Shervin, Panetta, John C, Spencer, Elizabeth A, Everts-van der Wind, Annelie, Dervieux, Thierry

“…Infliximab (IFX) concentrations are a predictive factor (PF) of pharmacokinetic (PK) origin in the treatment of Crohn's disease (CD). We evaluated Clearance,…”
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Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia by Kawedia, Jitesh D., Liu, Chengcheng, Pei, Deqing, Cheng, Cheng, Fernandez, Christian A., Howard, Scott C., Campana, Dario, Panetta, John C., Bowman, W. Paul, Evans, William E., Pui, Ching-Hon, Relling, Mary V.

“…We have previously hypothesized that higher systemic exposure to asparaginase may cause increased exposure to dexamethasone, both critical chemotherapeutic…”
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Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models by Karol, Seth E, Janke, Laura J, Panetta, John C, Ramsey, Laura B, Cai, Xiangjun, Payton, Monique A, Jenkins, David A, Evans, William E, Relling, Mary V

“…Combination therapy for acute lymphoblastic leukemia (ALL) is highly effective but results in significant toxicity including osteonecrosis. Asparaginase is…”
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Asparaginase May Influence Dexamethasone Pharmacokinetics in Acute Lymphoblastic Leukemia by LEI YANG, PANETTA, John C, XIANGJUN CAI, WENJIAN YANG, DEQING PEI, CHENG CHENG, KORNEGAY, Nancy, PUI, Ching-Hon, RELLING, Mary V

“…Dexamethasone is used widely in oncology, but pharmacokinetic studies are lacking. We evaluated dexamethasone pharmacokinetics in children with acute…”
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Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study by Panetta, John C., Campagne, Olivia, Gartrell, Jessica, Furman, Wayne, Stewart, Clinton F.

“…Sorafenib improves outcomes in adult hepatocellular carcinoma; however, hand foot skin reaction (HFSR) is a dose limiting toxicity of sorafenib that limits its…”
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Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy by Leggas, Markos, Adachi, Masashi, Scheffer, George L., Sun, Daxi, Wielinga, Peter, Du, Guoqing, Mercer, Kelly E., Zhuang, Yanli, Panetta, John C., Johnston, Brad, Scheper, Rik J., Stewart, Clinton F., Schuetz, John D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo by LEGGAS, Markos, PANETTA, John C, YANLI ZHUANG, SCHUETZ, John D, JOHNSTON, Brad, FENG BAI, SORRENTINO, Brian, SHENG ZHOU, HOUGHTON, Peter J, STEWART, Clinton F

“…The 4-anilinoquinazoline (4-AQ) derivative gefitinib (Iressa) is an oral epidermal growth factor receptor tyrosine kinase inhibitor. Oral administration of…”
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Population pharmacokinetic studies in pediatrics: issues in design and analysis by Meibohm, Bernd, Läer, Stephanie, Panetta, John C, Barrett, Jeffrey S

“…The current review addresses the following 3 frequently encountered challenges in the design and analysis of population pharmacokinetic studies in pediatrics:…”
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Genetics of pleiotropic effects of dexamethasone by Ramsey, Laura B, Pounds, Stan, Cheng, Cheng, Cao, Xueyuan, Yang, Wenjian, Smith, Colton, Karol, Seth E, Liu, Chengcheng, Panetta, John C, Inaba, Hiroto, Rubnitz, Jeffrey E, Metzger, Monika L, Ribeiro, Raul C, Sandlund, John T, Jeha, Sima, Pui, Ching-Hon, Evans, William E, Relling, Mary V

“…OBJECTIVESGlucocorticoids such as dexamethasone have pleiotropic effects, including desired antileukemic, anti-inflammatory, or immunosuppressive effects, and…”
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Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development by Gaur, Aditya H., Panetta, John C., Smith, Amber M., Dallas, Ronald H., Freeman, Burgess B., Stewart, Tracy B., Tang, Li, John, Elizabeth, Branum, Kristen C., Patel, Nehali D., Ost, Shelley, Heine, Ryan N., Richardson, Julie L., Hammill, Jared T., Bebrevska, Lidiya, Gusovsky, Fabian, Maki, Noritsugu, Yanagi, Toshiharu, Flynn, Patricia M., McCarthy, James S., Chalon, Stephan, Guy, R. Kiplin

“…SJ733, a newly developed inhibitor of P. falciparum ATP4, has a favorable safety profile and rapid antiparasitic effect but insufficient duration to deliver a…”
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Population PK/PD model of homocysteine concentrations after high-dose methotrexate treatment in patients with acute lymphoblastic leukemia by Rühs, Hauke, Becker, Achim, Drescher, Anne, Panetta, John C, Pui, Ching-Hon, Relling, Mary V, Jaehde, Ulrich

“…Elevated homocysteine concentrations have been associated with methotrexate-induced neurotoxicity. Based on methotrexate and homocysteine plasma concentrations…”
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