Search Results - "Panetta, J C"

Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia by Liu, C, Kawedia, J D, Cheng, C, Pei, D, Fernandez, C A, Cai, X, Crews, K R, Kaste, S C, Panetta, J C, Bowman, W P, Jeha, S, Sandlund, J T, Evans, W E, Pui, C-H, Relling, M V

“…Hypersensitivity to asparaginase is common, but the differential diagnosis can be challenging and the diagnostic utility of antibody tests is unclear. We…”
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Comparison of Native E. coli and PEG Asparaginase Pharmacokinetics and Pharmacodynamics in Pediatric Acute Lymphoblastic Leukemia by Panetta, J C, Gajjar, A, Hijiya, N, Hak, L J, Cheng, C, Liu, W, Pui, C H, Relling, M V

“…Asparaginase (ASP) is used routinely in frontline clinical trials for the treatment of childhood acute lymphoblastic leukemia (ALL). The goals of this study…”
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The effects of pazopanib on doxorubicin pharmacokinetics in children and adults with non-rhabdomyosarcoma soft tissue sarcoma: a report from Children’s Oncology Group and NRG Oncology study ARST1321 by Gartrell, J., Panetta, J. C., Baker, S. D., Chen, Y. L., Hawkins, D. S., Ostrenga, A., Scharschmidt, T. J., Spunt, S. L., Wang, D., Weiss, A. R.

“…Purpose The use of tyrosine kinase inhibitors for the treatment for soft tissue sarcomas is increasing given promising signals of activity in a variety of…”
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Genome‐Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy by Liu, Y, Fernandez, CA, Smith, C, Yang, W, Cheng, C, Panetta, JC, Kornegay, N, Liu, C, Ramsey, LB, Karol, SE, Janke, LJ, Larsen, EC, Winick, N, Carroll, WL, Loh, ML, Raetz, EA, Hunger, SP, Devidas, M, Yang, JJ, Mullighan, CG, Zhang, J, Evans, WE, Jeha, S, Pui, C‐H, Relling, MV

“…Remission induction therapy for acute lymphoblastic leukemia (ALL) includes medications that may cause hepatotoxicity, including asparaginase. We used a…”
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Correction: Population pharmacokinetics of fludarabine in patients with aplastic anemia and Fanconi anemia undergoing allogeneic hematopoietic stem cell transplantation by Mohanan, E., Panetta, J. C., Lakshmi, K. M., Edison, E. S., Korula, A., Fouzia, N. A., Abraham, A., Viswabandya, A., Mathews, V., George, B., Srivastava, A., Balasubramanian, P.

“…This article was originally published under a CC BY-NC-ND 4.0 license, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of…”
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Pharmacogenetic Pathway Analysis of Irinotecan by Rosner, GL, Panetta, JC, Innocenti, F, Ratain, MJ

“…Irinotecan, a chemotherapeutic agent against various solid tumors, is a prodrug requiring activation to SN‐38. Irinotecan's complex pharmacokinetics…”
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Successful challenges using native E. coli asparaginase after hypersensitivity reactions to PEGylated E. coli asparaginase by Fernandez, C. A., Stewart, E., Panetta, J. C., Wilkinson, M. R., Morrison, A. R., Finkelman, F. D., Sandlund, J. T., Pui, C. H., Jeha, S., Relling, M. V., Campbell, P. K.

“…Purpose Asparaginase is an essential component of pediatric acute lymphoblastic leukemia (ALL) therapy. However, asparaginase-induced hypersensitivity…”
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Population pharmacokinetics of cyclophosphamide in patients with thalassemia major undergoing HSCT by Balasubramanian, P, Desire, S, Panetta, J C, Lakshmi, K M, Mathews, V, George, B, Viswabandya, A, Chandy, M, Krishnamoorthy, R, Srivastava, A

“…CY in combination with BU is a widely used conditioning regimen for haematopoietic SCT (HSCT). The aim of this study was to evaluate the pharmacokinetics (PK)…”
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Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells by PANETTA, J. C, EVANS, W. E, CHEOK, M. H

“…The antimetabolite mercaptopurine (MP) is widely used to treat childhood acute lymphoblastic leukaemia (ALL). To study the dynamics of MP on the cell cycle, we…”
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Population pharmacokinetics of fludarabine in patients with aplastic anemia and Fanconi anemia undergoing allogeneic hematopoietic stem cell transplantation by Mohanan, E, Panetta, J C, Lakshmi, K M, Edison, E S, Korula, A, Fouzia, N A, Abraham, A, Viswabandya, A, Mathews, V, George, B, Srivastava, A, Balasubramanian, P

“…Although hematopoietic stem cell transplantation (HSCT) with a conditioning regimen consisting of fludarabine (F-araA) and cyclophosphamide (Cy) is associated…”
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A mathematical model of drug resistance: Heterogeneous tumors by Panetta, John Carl

“…A mathematical model is developed to describe the growth and control of a heterogeneous tumor. The main aspect of the model is that it takes into account…”
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A mathematical model of breast and ovarian cancer treated with paclitaxel by Panetta, John Carl

“…A mathematical model that describes the effects of cell-cycle-specific drugs on cancer and normal tissue is developed. The model takes into account the…”
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A mathematical model of cycle-specific chemotherapy by Panetta, J.C., Adam, J.

“…A mathematical model is used to discuss the effects of cycle-specific chemotherapy. The model includes a constraint equation which describes the effects of the…”
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The effect of body mass index at diagnosis on clinical outcome in children with newly diagnosed acute lymphoblastic leukemia by Eissa, H M, Zhou, Y, Panetta, J C, Browne, E K, Jeha, S, Cheng, C, Relling, M V, Campana, D, Pui, C-H, Inaba, H

“…The impact of body mass index (BMI) at diagnosis on treatment outcome in children with acute lymphoblastic leukemia (ALL) is controversial. We studied 373…”
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Controlling the doping of single-walled carbon nanotube networks by proton irradiation by Walker, D., Mann, C. J., Panetta, C. J., Alaan, D. R., Hopkins, A. R., Liu, S. H.

“…We demonstrate the controlled desorption of adventitious dopants on networks of single-walled carbon nanotubes (SWNTs) with 100 keV proton irradiation…”
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Modeling immunotherapy of the tumor-immune interaction by Kirschner, D, Panetta, J C

“…A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2) may boost the immune system to fight tumors. CD4+ T cells, the…”
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Plasmin proteolysis of endothelial cell and vessel wall associated tissue factor pathway inhibitor by Stalboerger, P G, Panetta, C J, Simari, R D, Caplice, N M

“…Plasmin is an important protease that mediates clot fibrinolysis and vessel wall extracellular matrix proteolysis. Recently, in vitro studies have suggested…”
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High‐dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma by Crews, Kristine R., Liu, Tiebin, Rodriguez‐Galindo, Carlos, Tan, Ming, Meyer, William H., Panetta, J. Carl, Link, Michael P., Daw, Najat C.

“…BACKGROUND High‐dose methotrexate (HDMTX) is used frequently in combination regimens that include nephrotoxic chemotherapy. The authors evaluated the impact of…”
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A simple mathematical model and alternative paradigm for certain chemotherapeutic regimens by Adam, J., Panetta, J.C.

“…A simplified two-compartment model for cell-specific chemotherapy is analysed by reformulating the governing system of differential equations as a Schrödinger…”
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A mathematical model of periodically pulsed chemotherapy: tumor recurrence and metastasis in a competitive environment by Panetta, J C

“…A competition model describing tumor-normal cell interaction with the added effects of periodically pulsed chemotherapy is discussed. The model describes…”
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