Search Results - "Panelli, Monica C."

JTM advances in uncharted territories: diseases and disorders of unknown etiology by Panelli, Monica C

“…We are delighted to announce a new section in the Journal of Translational Medicine, 'Illnesses of Unknown Etiology'. This section aims to provide a…”
Get full text

Serum Vascular Endothelial Growth Factor and Fibronectin Predict Clinical Response to High-Dose Interleukin-2 Therapy by SABATINO, Marianna, KIM-SCHULZE, Seunghee, KAUFMAN, Howard L, PANELLI, Monica C, STRONCEK, David, WANG, Ena, TABACK, Bret, DAE WON KIM, DERAFFELE, Gail, POS, Zoltan, MARINCOLA, Francesco M

“…High-dose interleukin-2 (IL-2) induces durable therapeutic responses in a small subset of patients with metastatic melanoma and renal cell carcinoma, but…”
Get full text

Next Generation of Immunotherapy for Melanoma by KIRKWOOD, John M, TARHINI, Ahmad A, PANELLI, Monica C, MOSCHOS, Stergios J, ZAROUR, Hassane M, BUTTERFIELD, Lisa H, GOGAS, Helen J

“…Immunotherapy has a long history with striking but limited success in patients with melanoma. To date, interleukin-2 and interferon-alfa2b are the only…”
Get full text

Gene expression profiling of cutaneous wound healing by Deonarine, Kavita, Panelli, Monica C, Stashower, Mitchell E, Jin, Ping, Smith, Kina, Slade, Herbert B, Norwood, Christopher, Wang, Ena, Marincola, Francesco M, Stroncek, David F

“…Although the sequence of events leading to wound repair has been described at the cellular and, to a limited extent, at the protein level this process has yet…”
Get full text

Microrna profiling analysis of differences between the melanoma of young adults and older adults by Jukic, Drazen M, Rao, Uma N M, Kelly, Lori, Skaf, Jihad S, Drogowski, Laura M, Kirkwood, John M, Panelli, Monica C

“…This study represents the first attempt to perform a profiling analysis of the intergenerational differences in the microRNAs (miRNAs) of primary cutaneous…”
Get full text

A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon by Wang, Ena, Zhao, Yingdong, Monaco, Alessandro, Uccellini, Lorenzo, Kirkwood, John M, Spyropoulou-Vlachou, Maria, Panelli, Monica C, Marincola, Francesco M, Gogas, Helen

“…IFNa was the first cytokine to demonstrate anti-tumor activity in advanced melanoma. Despite the ability of high-dose IFNa reducing relapse and mortality by up…”
Get full text

Common cancer biomarkers by BASIL, Christopher F, YINGDONG ZHAO, TAYLOR, Phil R, NAN HU, ZANOVELLO, Paola, MARINCOLA, Francesco M, WANG, Ena, ZAVAGLIA, Katia, PING JIN, PANELLI, Monica C, VOICULESCU, Sonia, MANDRUZZATO, Susanna, LEE, Hueling M, SELIGER, Barbara, FREEDMAN, Ralph S

“…There is an increasing interest in complementing conventional histopathologic evaluation with molecular tools that could increase the sensitivity and…”
Get full text

Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration by Panelli, Monica C, Wang, Ena, Phan, Giao, Puhlmann, Markus, Miller, Lance, Ohnmacht, Galen A, Klein, Harvey G, Marincola, Francesco M

“…Interleukin-2 (IL-2) has direct pluripotent effects on cells with immune and inflammatory function. Which of these effects has a critical role in mediating…”
Get full text

Comparison of proteomic profiles of serum, plasma, and modified media supplements used for cell culture and expansion by Ayache, Saleh, Panelli, Monica C, Byrne, Karen M, Slezak, Stefanie, Leitman, Susan F, Marincola, Francesco M, Stroncek, David F

“…The culture and expansion of human cells for clinical use requires the presence of human serum or plasma in culture media. Although these supplements have been…”
Get full text

Peritoneal and Subperitoneal Stroma May Facilitate Regional Spread of Ovarian Cancer by ENA WANG, NGALAME, Yvonne, MARINCOLA, Francesco M, PANELLI, Monica C, NGUYEN-JACKSON, Hoainam, DEAVERS, Michael, MUELLER, Peter, WEI HU, SAVARY, Cherylyn A, KOBAYASHI, Ryuji, FREEDMAN, Ralph S

“…Purpose: Epithelial ovarian cancer (EOC) is characterized by early peritoneal involvement ultimately contributing to morbidity and mortality. To study the role…”
Get full text

Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments by Aricò, Eleonora, Castiello, Luciano, Urbani, Francesca, Rizza, Paola, Panelli, Monica C, Wang, Ena, Marincola, Francesco M, Belardelli, Filippo

“…Interferons alpha (IFNα) are the cytokines most widely used in clinical medicine for the treatment of cancer and viral infections. Among the immunomodulatory…”
Get full text

Inflammatory protein profile during systemic high dose interleukin-2 administration by Rossi, Leonardo, Martin, Brian M., Hortin, Glen L., White, Richard L., Foster, Mareva, Moharram, Ramy, Stroncek, David, Wang, Ena, Marincola, Francesco M., Panelli, Monica C.

“…Systemic interleukin‐2 (IL‐2) administration induces an assortment of downstream effects whose biological and therapeutic significance remains unexplored…”
Get full text

Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets by Jin, Ping, Wang, Ena, Provenzano, Maurizio, Deola, Sara, Selleri, Silvia, Ren, Jiaqiang, Voiculescu, Sonia, Stroncek, David, Panelli, Monica C, Marincola, Francesco M

“…Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and…”
Get full text

Selection and validation of endogenous reference genes using a high throughput approach by Jin, Ping, Zhao, Yingdong, Ngalame, Yvonne, Panelli, Monica C, Nagorsen, Dirk, Monsurró, Vladia, Smith, Kina, Hu, Nan, Su, Hua, Taylor, Phil R, Marincola, Francesco M, Wang, Ena

“…Endogenous reference genes are commonly used to normalize expression levels of other genes with the assumption that the expression of the former is constant in…”
Get full text

Active-specific immunization against melanoma: Is the problem at the receiving end? by Monsurrò, Vladia, Wang, Ena, Panelli, Monica C, Nagorsen, Dirk, Jin, Ping, Katia, Zavaglia, Smith, Kina, Ngalame, Yvonne, Even, Jos, Marincola, Francesco M

“…The recent progress in tumor immunology is a striking example of the successful application of modern biotechnology to understand the complex phenomenon of…”
Get full text

The dual role of IL-10 by Mocellin, Simone, Panelli, Monica C, Wang, Ena, Nagorsen, Dirk, Marincola, Francesco M

“…Classification of cytokines as pro- versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that…”
Get full text

The pathway to biomarker discovery : Carbonic anhydrase IX and the prediction of immune responsiveness by PANELLI, Monica C, ENA WANG, MARINCOLA, Francesco M

Get full text

Melanoma-restricted genes by Wang, Ena, Panelli, Monica C, Zavaglia, Katia, Mandruzzato, Susanna, Hu, Nan, Taylor, Phil R, Seliger, Barbara, Zanovello, Paola, Freedman, Ralph S, Marincola, Francesco M

“…Human metastatic cutaneous melanoma has gained a well deserved reputation for its immune responsiveness. The reason(s) remain(s) unknown. We attempted…”
Get full text

GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells by Selleri, Silvia, Deola, Sara, Pos, Zoltan, Jin, Ping, Worschech, Andrea, Slezak, Stefanie L, Rumio, Cristiano, Panelli, Monica C, Maric, Dragan, Stroncek, David F, Wang, Ena, Marincola, Francesco M

“…Upon Ag-activation cytotoxic T cells (CTLs) produce IFN-gamma GM-CSF and TNF-alpha, which deliver simultaneously pro-apoptotic and pro-inflammatory signals to…”
Get full text

A global approach to tumor immunology by Wang, Ena, Panelli, Monica C, Monsurró, Vladia, Marincola, Francesco M

“…Biological and clinical advances in the understanding of tumor immunology suggest that immune responsiveness of human tumors is a complex biological phenomenon…”
Get full text