Search Results - "Panek, James S."

Stereocontrolled Synthesis of Spirooxindoles through Lewis Acid-Promoted [5 + 2]-Annulation of Chiral Silyl Alcohols by Zhang, Yun, Panek, James S

“…The enantioselective synthesis of stereochemically and structurally diverse spirocyclic oxindoles by [5 + 2]-annulation of chiral crotylsilanes bearing a…”
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Vinylogous Aldol Products from Chiral Crotylsilanes Obtained by Enantioselective Rh(II) and Cu(I) Carbenoid Si−H Insertion by Wu, Jie, Chen, Yu, Panek, James S.

“…Enantioenriched homoallylic ethers containing a α,β-unsaturated ester (syn-vinylogous aldol products) were directly accessed by Lewis acid catalyzed…”
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Rhodium(II)-Catalyzed Alkyne Amination of Homopropargylic Sulfamate Esters: Stereoselective Synthesis of Functionalized Norcaradienes by Arene Cyclopropanation by Brawn, Ryan A, Zhu, Kaicheng, Panek, James S

“…A rhodium(II) catalyzed nitrene–alkyne cycloaddition of stereochemically well-defined homopropargylic ethers is followed by arene cyclopropanation to afford…”
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Total Synthesis of (−)-Virginiamycin M2 by Wu, Jie, Panek, James S.

“…Has a nice ring to it: A concise and modular total synthesis of the naturally occurring antibiotic virginiamycin M2 is described. A Barbier‐type cyclization…”
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Total Synthesis and Stereochemical Reassignment of (+)-Neopeltolide by Youngsaye, Willmen, Lowe, Jason T, Pohlki, Frauke, Ralifo, Paul, Panek, James S

“…Take a closer look! The first enantioselective total synthesis, stereochemical reassignment, and absolute configuration of the metabolite neopeltolide is…”
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Synthesis of Enantioenriched Homopropargylic Sulfonamides by a Three Component Reaction of Aldehydes, Sulfonamides, and Chiral Allenylsilanes by Brawn, Ryan A, Panek, James S

“…Enantioenriched allenylsilanes are used as carbon nucleophiles in three-component reactions with in situ generated N-sulfonylimines to selectively form…”
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Preparation and Use of Enantioenriched Allenylsilanes for the Stereoselective Synthesis of Homopropargylic Ethers by Brawn, Ryan A, Panek, James S

“…A convenient procedure for the synthesis of highly enantioenriched allenylsilanes by Johnson orthoester Claisen rearrangement of 1-silyl propargylic alcohols…”
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[4 + 2]-Annulations of Chiral Organosilanes:  Application to the Total Synthesis of Leucascandrolide A by Su, Qibin, Dakin, Les A, Panek, James S

“…Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 +…”
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Crotylsilane Reagents in the Synthesis of Complex Polyketide Natural Products:  Total Synthesis of (+)-Discodermolide by Arefolov, Alexander, Panek, James S

“…An efficient, highly convergent stereocontrolled synthesis of (+)-discodermolide has been achieved with 2.1% overall yield (27 steps longest linear sequence)…”
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Synthesis of a 35-Member Stereoisomer Library of Bistramide A: Evaluation of Effects on actin State, Cell Cycle and Tumor Cell Growth by Wrona, Iwona E, Lowe, Jason T, Turbyville, Thomas J, Johnson, Tanya R, Beignet, Julien, Beutler, John A, Panek, James S

“…Synthesis and preliminary biological evaluation of a 35-member library of bistramide A stereoisomers are reported. All eight stereoisomers of the C1−C13…”
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Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions by Wu, Jie, Becerril, Jorge, Lian, Yajing, Davies, Huw M. L., Porco Jr, John A., Panek, James S.

“…All in order: Bicyclic and tricyclic chemotypes were accessed through the title transformations. By subsequent pairing of installed functional groups using…”
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Organosilanes in Synthesis:  Application to an Enantioselective Synthesis of Methyl-l-callipeltose by Huang, Hongbing, Panek, James S

“…Methyl-l-callipeltose, the carbohydrate associated with callipeltoside A, has been synthesized in eight steps and 23% overall yield from enantioenriched…”
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Total Synthesis of (+)-Leucascandrolide A by Su, Qibin, Panek, James S.

“…A convergent and enantioselective total synthesis of (+)‐leucascandrolide (1) was accomplished in 17 steps. Central to this synthesis is the rapid and…”
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Titanium Alkoxide-Based Regioselective Alkyne–Alkyne Reductive Coupling Mediated by In Situ Generated Arylamidate by Cai, Bin, Panek, James S

“…Titanium alkoxide-based alkyne–alkyne reductive coupling mediated by in situ generated arylamidate is described. A high level of regioselectivity is achieved…”
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A Convergent Synthesis of the Macrocyclic Core of Cytotrienins:  Application of RCM for Macrocyclization by Evano, Gwilherm, Schaus, Jennifer V, Panek, James S

“…The asymmetric synthesis of the fully elaborated macrocyclic core of cytotrienins A−D, potent apoptosis-inducing agents, is described. Synthetic highlights…”
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Multicomponent Condensation Reactions via ortho-Quinone Methides by Allen, Emily E, Zhu, Calvin, Panek, James S, Schaus, Scott E

“…Iron­(III) salts promote the condensation of aldehydes or acetals with electron-rich phenols to generate ortho-quinone methides that undergo DielsAlder…”
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Convergent Synthesis of Novel Muramyl Dipeptide Analogues: Inhibition of Porphyromonas gingivalis-Induced Pro-inflammatory Effects by High Doses of Muramyl Dipeptide by Cai, Bin, Panek, James S, Amar, Salomon

“…Porphyromonas gingivalis (P.g.)-induced TNF-α can be affected by muramyl dipeptide (MDP) in a biphasic concentration-dependent manner. We found that in…”
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Total Synthesis of (+)-Isatisine A: Application of a Silicon-Directed Mukaiyama-Type [3 + 2]-Annulation by Lee, Jihoon, Panek, James S

“…Complete details of an asymmetric synthesis of (+)-isatisine A (1) are described. The synthesis highlights the use of a highly diastereoselective…”
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Kava analogues as agents for treatment of periodontal diseases: Synthesis and initial biological evaluation by Cai, Bin, Panek, James S., Amar, Salomon

“…[Display omitted] •New kava analogues as agents for treatment of periodontal diseases.•15 was found to significantly reduce P. gingivalis induced TNF-α…”
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Total Synthesis of (+)-Isatisine A by Lee, Jihoon, Panek, James S.

“…Total synthesis of (+)-isatisine A is described based on the application of a silyl-directed Mukaiyama-type [3 + 2]-annulation for the preparation of a fully…”
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