Search Results - "Pandya, Vrajesh"

Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor‑γ (RORγ or RORc) Inhibitors: Hits and Misses by Pandya, Vrajesh B, Kumar, Sanjay, Sachchidanand, Sharma, Rajiv, Desai, Ranjit C

“…The nuclear receptor retinoic acid receptor-related orphan receptor gamma (RORγ or RORc) is a key transcription factor for the production of pro-inflammatory…”
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Prolyl Hydroxylase Inhibitors: A Breakthrough in the Therapy of Anemia Associated with Chronic Diseases by Joharapurkar, Amit A., Pandya, Vrajesh B., Patel, Vishal J., Desai, Ranjit C., Jain, Mukul R.

“…Chronic kidney disease, cancer, chronic inflammatory disorders, nutritional, and genetic deficiency can cause anemia. Hypoxia causes induction of…”
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BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models by Githaka, John Maringa, Tripathi, Namita, Kirschenman, Raven, Patel, Namrata, Pandya, Vrajesh, Kramer, David A., Montpetit, Rachel, Zhu, Lin Fu, Sonenberg, Nahum, Fahlman, Richard P., Danial, Nika N., Underhill, D. Alan, Goping, Ing Swie

“…Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in…”
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BIK drives an aggressive breast cancer phenotype through sublethal apoptosis and predicts poor prognosis of ER-positive breast cancer by Pandya, Vrajesh, Githaka, John Maringa, Patel, Namrata, Veldhoen, Richard, Hugh, Judith, Damaraju, Sambasivarao, McMullen, Todd, Mackey, John, Goping, Ing Swie

“…Apoptosis is fundamental to normal animal development and is the target for many anticancer therapies. Recent studies have explored the consequences of “failed…”
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Desidustat: a novel PHD inhibitor for the treatment of CKD-induced anemia by Joharapurkar, Amit, Pandya, Vrajesh, Patel, Harilal, Jain, Mukul, Desai, Ranjit

“…Desidustat is a small molecule inhibitor of hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) discovered and developed by Zydus Lifesciences for the…”
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Resveratrol and Resveratrol-Aspirin Hybrid Compounds as Potent Intestinal Anti-Inflammatory and Anti-Tumor Drugs by Salla, Mohamed, Pandya, Vrajesh, Bhullar, Khushwant S, Kerek, Evan, Wong, Yoke Fuan, Losch, Robyn, Ou, Joe, Aldawsari, Fahad S, Velazquez-Martinez, Carlos, Thiesen, Aducio, Dyck, Jason R B, Hubbard, Basil P, Baksh, Shairaz

“…Resveratrol (3,4,5-Trihydroxy-trans-stilbene) is a naturally occurring polyphenol that exhibits beneficial pleiotropic health effects. It is one of the most…”
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Detection of a High-Dose Hook Effect and Evaluation of Dilutions of Urine Myoglobin Specimens Using a Serum Myoglobin Assay by Hunsaker, Joshua Joon Hyung, La'ulu, Sonia Leilani, Zupan, Emily, Patel, Dhwani, Pandya, Vrajesh, Rudolf, Joseph William

“…KCI Citation Count: 0…”
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Commentary on Unexpected Fentanyl Detection during a Liver Transplant Evaluation by Pandya, Vrajesh

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Synthesis and structure–activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: Application of weakly basic sulfoximine group as novel S4 binding element by Pandya, Vrajesh, Jain, Mukul, Chakrabarti, Ganes, Soni, Hitesh, Parmar, Bhavesh, Chaugule, Balaji, Patel, Jigar, Jarag, Tushar, Joshi, Jignesh, Joshi, Nirav, Rath, Akshyaya, Unadkat, Vishal, Sharma, Bhavesh, Ajani, Haresh, Kumar, Jeevan, Sairam, Kalapatapu V.V.M., Patel, Harilal, Patel, Pankaj

“…A novel series of potent and efficacious factor Xa inhibitors which possesses sulfoximine moiety as novel S4 binding element in anthranilamide chemotype has…”
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Efficient Synthesis of Unsymmetrical Dibenzothiophenes by Acid-Mediated Intramolecular Cyclization of Biaryl Methyl Sulfoxides by Pandya, Vrajesh B., Jain, Mukul R., Chaugule, Balaji V., Patel, Jigar S., Parmar, Bhavesh M., Joshi, Jignesh K., Patel, Pankaj R.

“…A convenient and high-yielding synthesis of unsymmetrical dibenzothiophenes has been achieved by an acid-mediated ring closure of the biphenyl ring having a…”
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A sensitive assay for ZYAN1 in human whole blood and urine utilizing positive LC-MS/MS electrospray ionization by Patel, Harilal, Soni, Krunal, Trivedi, Rucha, Heading, Heather, Geue, Jason, Kansagra, Kevinkumar, Gupta, Rahul J, Pandya, Vrajesh B, Srinivas, Nuggehally R, Patel, Pankaj R, Desai, Ranjit C

“…: A sensitive LC-MS/MS method was developed and validated for estimation of ZYAN1 in human blood/urine. : An analog internal standard IOX2 along with ZYAN1 was…”
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Deceptively simple: Can urine samples from NexScreen cup be re-used for confirmatory testing? by Pandya, Vrajesh, McMillin, Gwendolyn, Young, Brittany

“…Abstract Background The NexScreen urine drug screen cup (SKU: HCDOAV-8145EF1KT, NexScreen LLC, CO, USA) is a Clinical Laboratory Improvement Act (CLIA)-waived…”
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Connected by the cord—comparison of drug positivity rates and concentrations in a large cohort of paired umbilical cord and meconium specimens by Pandya, Vrajesh, Wilker, Chase, McMillin, Gwendolyn

“…Abstract Substance abuse during pregnancy has significant short- and long-term health, social, and legal implications. Hence, prompt determination of a…”
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Can Umbilical Cord and Meconium Results Be Directly Compared? Analytical Approach Matters by Pandya, Vrajesh, Wilker, Chase, McMillin, Gwendolyn A

“…Maternal drug use during pregnancy is a significant concern. Drug-exposed newborns are often born premature and may suffer from birth defects, neonatal…”
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Longitudinal trends in meconium drug detection in 46 US states between the years 2015 and 2020 by Pandya, Vrajesh, Wilker, Chase, Johnson-Davis, Kamisha L

“…Abstract Maternal drug use during pregnancy has significant health and socio-legal implications. The Substance Abuse and Mental Health Services Administration…”
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Nonclinical Pharmacokinetic Evaluation of Desidustat: a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia by Patel, Harilal, Modi, Nirav, Chaudhari, Jaimin, Patel, Prakash, Giri, Poonam, Patel, Hiren, Pandya, Vrajesh, Desai, Ranjit, Jain, Mukul

“…Background and Objectives Desidustat is a novel prolyl hydroxylase domain (PHD) inhibitor for the treatment of anemia. The objective of this study was to…”
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Spirited away: Can ethanol testing in add-on orders provide meaningful results? by Pandya, Vrajesh, Nguyen Sorenson, Anh H.T., Jones, Erin, Young, Brittany A., Pearson, Lauren N.

“…Ethanol is a volatile substance, and specimens need to be tightly capped prior to analysis to prevent evaporative loss. However, add-on requests in previously…”
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Hyperuricemia in a patient with Waldenström’s Macroglobulinemia: An innocent bystander? by Smith, Zachary, Goyal, Pankaj, Pandya, Vrajesh, Thakar, Charuhas V, Gudsoorkar, Prakash S

“…Background: Paraproteins often cause factitious biochemical measurements by forming opaque precipitates with the test reagents and interfering with various…”
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Deceptively Simple: Can Urine Samples from CLIA-Waived Urine Drug Screen Devices Be Reused for Confirmatory Testing? by Pandya, Vrajesh, McMillin, Gwendolyn A, Young, Brittany A

“…Abstract Background Many low-complexity urine drug screen (UDS) devices are approved by the Food and Drug Administration as waived under Clinical Laboratory…”
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The pro-apoptotic paradox: the BH3-only protein Bcl-2 interacting killer (Bik) is prognostic for unfavorable outcomes in breast cancer by Pandya, Vrajesh, Glubrecht, Darryl, Vos, Larissa, Hanson, John, Damaraju, Sambasivarao, Mackey, John, Hugh, Judith, Goping, Ing Swie

“…Breast cancer is the leading cause of cancer-associated deaths in women worldwide. Clinical biomarkers give information on disease progression and identify…”
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