Search Results - "Pandya, Manisha"
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1
Azithromycin Exhibits Activity Against Pseudomonas aeruginosa in Chronic Rat Lung Infection Model
Published in Frontiers in microbiology (23-04-2021)“…forms biofilms in the lungs of chronically infected cystic fibrosis patients, which are tolerant to both the treatment of antibiotics and the host immune…”
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In Vitro and In Vivo Activities of the Novel Ketolide RBx 14255 against Clostridium difficile
Published in Antimicrobial Agents and Chemotherapy (01-11-2012)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Synthesis and antimicrobial activity of novel thiazolidinones
Published in ARKIVOC (19-01-2005)Get full text
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4
Efficacy of linezolid against Staphylococcus aureus in different rodent skin and soft tissue infections models
Published in Microbiology research (06-07-2011)“…Linezolid is approved for complicated and uncomplicated skin and soft tissue infections. We have evaluated the efficacy of this drug in murine as well as in…”
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In Vitro and In Vivo Activities of DS86760016, a Novel Leucyl-tRNA Synthetase Inhibitor for Gram-Negative Pathogens
Published in Antimicrobial agents and chemotherapy (01-04-2018)“…The emergence of multidrug-resistant (MDR) Gram-negative bacilli is a major concern in the treatment of nosocomial infections. Antibacterial agents with novel…”
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6
Novel FtsZ inhibitor with potent activity against Staphylococcus aureus
Published in Journal of antimicrobial chemotherapy (11-10-2021)“…Abstract Objectives FtsZ is an essential bacterial protein and an unexplored target for the development of antibacterial drugs. The development of a novel…”
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DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa
Published in Antimicrobial agents and chemotherapy (01-04-2019)“…DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum…”
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8
Novel fluorobenzothiazole as a dual inhibitor of gyrase B and topoisomerase IV against Gram-positive pathogens
Published in Future microbiology (01-07-2023)“…The development of a novel inhibitor targeting gyrase B and topoisomerase IV offers an opportunity to combat multidrug resistance. We investigated the activity…”
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Potential of the fluoroketolide RBx 14255 against Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae in an experimental murine meningitis model
Published in Journal of antimicrobial chemotherapy (01-07-2019)“…Abstract Background RBx 14255 is a fluoroketolide in pre-clinical evaluation with potent activity against MDR Gram-positive pathogens. Objectives To…”
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10
In Vitro and In Vivo Activities of a Bi-Aryl Oxazolidinone, RBx 11760, against Gram-Positive Bacteria
Published in Antimicrobial agents and chemotherapy (01-12-2016)“…RBx 11760, a bi-aryl oxazolidinone, was investigated for antibacterial activity against Gram-positive bacteria. The MIC s of RBx 11760 and linezolid against…”
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Rapid diagnosis of typhoid fever by detection of Barber protein and Vi antigen of Salmonella serotype Typhi
Published in Journal of medical microbiology (01-09-1995)“…Department of Microbiology, Lady Hardinge Medical College, New Delhi 110001, India Received February 22, 1994 Accepted February 9, 1995 Co-agglutination…”
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Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens
Published in Bioorganic & medicinal chemistry letters (01-01-2012)“…A novel series of acylides 4 were designed to overcome antibacterial resistance and evaluated for in vitro and in vivo activity. This series of acylides was…”
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Synthesis and biological activity of novel oxazolidinones
Published in Bioorganic & medicinal chemistry letters (15-11-2009)“…A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized and their antibacterial activity reported. A number of…”
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Non invasive real-time monitoring of bacterial infection & therapeutic effect of anti-microbials in five mouse models
Published in Indian journal of medical research (New Delhi, India : 1994) (01-11-2011)“…In vivo imaging system has contributed significantly to the understanding of bacterial infection and efficacy of drugs in animal model. We report five rapid,…”
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Synthesis and SAR of novel oxazolidinones: Discovery of ranbezolid
Published in Bioorganic & medicinal chemistry letters (01-10-2005)“…Substitution of five-membered heterocycles on to the ‘piperazinyl–phenyl–oxazolidinone’ core structure led to the identification of ranbezolid as a clinical…”
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Novel biaryl oxazolidinones: in vitro and in vivo activities with pharmacokinetics in an animal model
Published in International journal of antimicrobial agents (01-03-2009)“…Abstract RBx 1000075 and RBx 1000276, the new investigational oxazolidinones, have an extended spectrum of in vitro activity against Gram-positive pathogens…”
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Activity of a novel series of acylides active against community-acquired respiratory pathogens
Published in International journal of antimicrobial agents (01-08-2010)“…Abstract Resistance to macrolides and β-lactams has increased sharply amongst key respiratory pathogens, leading to major concern. A novel series of acylides…”
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Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position
Published in Bioorganic & medicinal chemistry letters (01-09-2007)“…Novel oxazolidinone derivatives of the lead compound RBx 8700 containing methylene oxygen- and methylene sulfur-linked substituents at C5-position were…”
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In vitro activity of RBx 7644 (ranbezolid) on biofilm producing bacteria
Published in International journal of antimicrobial agents (01-10-2004)“…Biofilm associated infections are becoming more common. Treatment outcome of device related infections cannot be predicted by the results of a standard…”
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Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700
Published in Bioorganic & medicinal chemistry letters (15-12-2007)“…The potent broad spectrum oxazolidinone antibacterial agent RBx 8700 ( 6b) was obtained by systematic modification of the methylene linker of RBx 7644…”
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