Search Results - "Pandol, SJ"

Acute Pancreatitis: Bench to the Bedside by Pandol, Stephen J, Saluja, Ashok K, Imrie, Clement W, Banks, Peter A

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The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis by Sandoval, D, Gukovskaya, A, Reavey, P, Gukovsky, S, Sisk, A, Braquet, P, Pandol, SJ, Poucell-Hatton, S

“…BACKGROUND & AIMS: Pancreatitis is characterized by inflammation and death of acinar cells. Death can occur by either necrosis or apoptosis. The initial injury…”
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Cell death in pancreatitis: caspases protect from necrotizing pancreatitis by Mareninova, Olga A, Sung, Kai-Feng, Hong, Peggy, Lugea, Aurelia, Pandol, Stephen J, Gukovsky, Ilya, Gukovskaya, Anna S

“…Mechanisms of cell death in pancreatitis remain unknown. Parenchymal necrosis is a major complication of pancreatitis; also, the severity of experimental…”
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Reactive Oxygen Species Produced by NAD(P)H Oxidase Inhibit Apoptosis in Pancreatic Cancer Cells by Vaquero, Eva C, Edderkaoui, Mouad, Pandol, Stephen J, Gukovsky, Ilya, Gukovskaya, Anna S

“…One reason why pancreatic cancer is so aggressive and unresponsive to treatments is its resistance to apoptosis. We report here that reactive oxygen species…”
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Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat by Gukovskaya, AS, Perkins, P, Zaninovic, V, Sandoval, D, Rutherford, R, Fitzsimmons, T, Pandol, SJ, Poucell-Hatton, S

“…BACKGROUND & AIMS: Mechanisms of cell death in human and experimental pancreatitis remain poorly understood. The aim of this study was to determine the…”
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Cathepsin H–Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells by Yang, Zemin, Liu, Yu, Qin, Lan, Wu, Pengfei, Xia, Zanxian, Luo, Mei, Zeng, Yilan, Tsukamoto, Hidekazu, Ju, Zongyun, Su, Danmei, Kang, Han, Xiao, Zhixiong, Zheng, Sujun, Duan, Zhongping, Hu, Richard, Wang, Qiang, Pandol, Stephen J, Han, Yuan-Ping

“…In three-dimensional extracellular matrix, mesenchymal cells including hepatic stellate cells (HSCs) gain the ability to express matrix metalloproteinases…”
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Food‐derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis by Mouria, Michelle, Gukovskaya, Anna S., Jung, Yoon, Buechler, Peter, Hines, Oscar J., Reber, Howard A., Pandol, Stephen J.

“…There is increasing evidence that food‐derived polyphenols have a beneficial effect for cancers. Our purpose was to determine the effect and mechanism of…”
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Cell death pathways in pancreatitis and pancreatic cancer by Gukovskaya, Anna S., Pandol, Stephen J.

“…The understanding of the regulation of apoptosis and necrosis, the two principal cell death pathways, is becoming exceedingly important in investigations of…”
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Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis by Gukovskaya, Anna S., Vaquero, Eva, Zaninovic, Vjekoslav, Gorelick, Fred S., Lusis, Aldons J., Brennan, Marie-Luise, Holland, Steven, Pandol, Stephen J.

“…Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to…”
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Extracellular matrix stimulates reactive oxygen species production and increases pancreatic cancer cell survival through 5-lipoxygenase and NADPH oxidase by Edderkaoui, Mouad, Hong, Peggy, Vaquero, Eva C, Lee, Jong K, Fischer, Lars, Friess, Helmut, Buchler, Markus W, Lerch, Markus M, Pandol, Stephen J, Gukovskaya, Anna S

“…The extracellular matrix (ECM) facilitates pancreatic cancer cells survival, which is of central importance for pancreatic adenocarcinoma that is highly…”
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Curcumin ameliorates ethanol and nonethanol experimental pancreatitis by Gukovsky, Ilya, Reyes, Christopher N, Vaquero, Eva C, Gukovskaya, Anna S, Pandol, Stephen J

“…Treatments for pancreatitis are limited. Activation of transcription factor NF-kappaB, a key regulator of inflammatory molecule expression, is an early event…”
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Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis by Gukovskaya, Anna S, Gukovsky, Ilya, Jung, Yoon, Mouria, Michelle, Pandol, Stephen J

“…Apoptosis and necrosis are critical parameters of pancreatitis, the mechanisms of which remain unknown. Many characteristics of pancreatitis can be studied in…”
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Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats by Gukovskaya, Anna S., Mouria, Michelle, Gukovsky, Ilya, Reyes, Christopher N., Kasho, Vladimir N., Faller, Larry D., Pandol, Stephen J.

“…Ethanol metabolism by pancreatic acinar cells and the role of its metabolites in ethanol toxicity to the pancreas remain largely unknown. Here, we characterize…”
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Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis by Gukovskaya, A S, Gukovsky, I, Zaninovic, V, Song, M, Sandoval, D, Gukovsky, S, Pandol, S J

“…The aim of this study was to determine whether tumor necrosis factor-alpha (TNFalpha) and receptors for TNFalpha are expressed in the exocrine pancreas, and…”
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PKC[epsilon] is a critical mediator of necrosis in acute pancreatitis by regulation of mitochondrial and non-mitochondrial death pathways by Liu, Y, Yuan, J, Tan, T, Jia, W, Lugea, A, Gukovskaya, AS, Pandol, SJ

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Alcohol and pancreatic cancer by Go, Vay Liang W., Gukovskaya, Anna, Pandol, Stephen J.

“…Findings obtained from numerous prospective cohort and case-control studies on alcohol consumption and pancreatic cancer risk have been inconsistent, with many…”
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Phosphatidylinositide 3-kinase γ regulates key pathologic responses to cholecystokinin in pancreatic acinar cells by Gukovsky, Ilya, Cheng, Jason H., Nam, Kyung J., Lee, Oliver T., Lugea, Aurelia, Fischer, Lars, Penninger, Josef M., Pandol, Stephen J., Gukovskaya, Anna S.

“…Background & Aims : Early events in the pancreatic acinar cell critical for development of pancreatitis include activation of the transcription factor nuclear…”
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Tumor Necrosis Factor-α Mediates Pancreatitis Responses in Acinar Cells via Protein Kinase C and Proline-Rich Tyrosine Kinase 2 by Satoh, Akihiko, Gukovskaya, Anna S., Edderkaoui, Mouad, Daghighian, Melissa S., Reeve, Joseph R., Shimosegawa, Tooru, Pandol, Stephen J.

“…Background & Aims: Although tumor necrosis factor α is implicated as an important mediator of the inflammatory response in acute pancreatitis, its role in…”
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Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions by Edderkaoui, M, Abrol, R, Lee, P, Goddard, W.A, Pandol, S.J

“…Methods: We applied structural analysis and computational modeling of the inter-residue interactions at the Bcl-xL:Bim protein-protein interface to predict and…”
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Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways by Vaquero, Eva C, Edderkaoui, Mouad, Nam, Kyung J, Gukovsky, Ilya, Pandol, Stephen J, Gukovskaya, Anna S

“…Background & Aims : Pancreatic cancer is a very aggressive malignancy. Normal cells die through apoptosis when detached from extracellular matrix (ECM), but…”
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