Search Results - "Pandha, H"

The role of HOX genes in normal hematopoiesis and acute leukemia by Alharbi, R A, Pettengell, R, Pandha, H S, Morgan, R

“…The homeobox ( HOX) genes are a highly conserved family of homeodomain-containing transcription factors that specify cell identity in early development and,…”
Get full text

HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer) by Plowright, L, Harrington, K J, Pandha, H S, Morgan, R

“…The HOX genes are a family of homeodomain-containing transcription factors that determine the identity of cells and tissues during embryonic development. They…”
Get full text

Measles virus causes immunogenic cell death in human melanoma by Donnelly, O G, Errington-Mais, F, Steele, L, Hadac, E, Jennings, V, Scott, K, Peach, H, Phillips, R M, Bond, J, Pandha, H, Harrington, K, Vile, R, Russell, S, Selby, P, Melcher, A A

“…Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not…”
Get full text

Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy by Ilett, E, Kottke, T, Thompson, J, Rajani, K, Zaidi, S, Evgin, L, Coffey, M, Ralph, C, Diaz, R, Pandha, H, Harrington, K, Selby, P, Bram, R, Melcher, A, Vile, R

“…The anti-tumour effects associated with oncolytic virus therapy are mediated significantly through immune-mediated mechanisms, which depend both on the type of…”
Get full text

The biology of the sodium iodide symporter and its potential for targeted gene delivery by Hingorani, Mohan, Spitzweg, Christine, Vassaux, Georges, Newbold, Kate, Melcher, Alan, Pandha, Hardev, Vile, Richard, Harrington, Kevin

“…The sodium iodide symporter (NIS) is responsible for thyroidal, salivary, gastric, intestinal and mammary iodide uptake. It was first cloned from the rat in…”
Get more information

Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity by Ilett, E J, Prestwich, R J, Kottke, T, Errington, F, Thompson, J M, Harrington, K J, Pandha, H S, Coffey, M, Selby, P J, Vile, R G, Melcher, A A

“…Reovirus is a naturally occurring oncolytic virus currently in early clinical trials. However, the rapid induction of neutralizing antibodies represents a…”
Get full text

Adjuvant sunitinib in patients with high-risk renal cell carcinoma: safety, therapy management, and patient-reported outcomes in the S-TRAC trial by Staehler, M., Motzer, R.J., George, D.J., Pandha, H.S., Donskov, F., Escudier, B., Pantuck, A.J., Patel, A., DeAnnuntis, L., Bhattacharyya, H., Ramaswamy, K., Zanotti, G., Lin, X., Lechuga, M., Serfass, L., Paty, J., Ravaud, A.

“…Adjuvant sunitinib has significantly improved disease-free survival versus placebo in patients with renal cell carcinoma at high risk of recurrence…”
Get full text

Low dose metronomic oral cyclophosphamide for hormone resistant prostate cancer: a phase II study by Lord, R, Nair, S, Schache, A, Spicer, J, Somaihah, Navita, Khoo, V, Pandha, H

“…Cyclophosphamide is a bifunctional alkylating agent long associated with immune activation. Continuous, uninterrupted, low (so-called metronomic) doses of…”
Get more information

Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial by White, C L, Twigger, K R, Vidal, L, De Bono, J S, Coffey, M, Heinemann, L, Morgan, R, Merrick, A, Errington, F, Vile, R G, Melcher, A A, Pandha, H S, Harrington, K J

“…There is an emerging realization from animal models that the immune response may have both detrimental and beneficial therapeutic effects during cancer…”
Get full text

Science in Focus – Oncolytic Viruses: New Multifunctional Immunotherapeutics by Pandha, H.S

Get full text

Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study by Larkin, S E T, Johnston, H E, Jackson, T R, Jamieson, D G, Roumeliotis, T I, Mockridge, C I, Michael, A, Manousopoulou, A, Papachristou, E K, Brown, M D, Clarke, N W, Pandha, H, Aukim-Hastie, C L, Cragg, M S, Garbis, S D, Townsend, P A

“…Background: Prostate cancer (PCa) is the most common male cancer in the United Kingdom and we aimed to identify clinically relevant biomarkers corresponding to…”
Get full text

Lymphokine‐activated killer and dendritic cell carriage enhances oncolytic reovirus therapy for ovarian cancer by overcoming antibody neutralization in ascites by Jennings, V.A., Ilett, E.J., Scott, K.J., West, E.J., Vile, R., Pandha, H., Harrington, K., Young, A., Hall, G.D., Coffey, M., Selby, P., Errington‐Mais, F., Melcher, A.A.

“…Reovirus is an oncolytic virus (OV), which acts by both direct tumor cell killing and priming of antitumor immunity. A major obstacle for effective oncolytic…”
Get full text

Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer by Mansfield, D C, Kyula, J N, Rosenfelder, N, Chao-Chu, J, Kramer-Marek, G, Khan, A A, Roulstone, V, McLaughlin, M, Melcher, A A, Vile, R G, Pandha, H S, Khoo, V, Harrington, K J

“…Oncolytic strains of vaccinia virus are currently in clinical development with clear evidence of safety and promising signs of efficacy. Addition of…”
Get full text

Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma by Errington, F, White, C L, Twigger, K R, Rose, A, Scott, K, Steele, L, Ilett, L J, Prestwich, R, Pandha, H S, Coffey, M, Selby, P, Vile, R, Harrington, K J, Melcher, A A

“…Reovirus is a promising unmodified double-stranded RNA (dsRNA) anti-cancer oncolytic virus, which is thought to specifically target cells with activated Ras…”
Get full text

Loss of expression of antigen-presenting molecules in human pancreatic cancer and pancreatic cancer cell lines by Pandha, H, Rigg, A, John, J, Lemoine, N

“…Tumours evade immune recognition and destruction through loss or down-regulation of expression of antigen processing and antigen-presenting molecules such as…”
Get full text

Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin–paclitaxel doublet chemotherapy by Roulstone, V, Twigger, K, Zaidi, S, Pencavel, T, Kyula, J N, White, C, McLaughlin, M, Seth, R, Karapanagiotou, E M, Mansfield, D, Coffey, M, Nuovo, G, Vile, R G, Pandha, H S, Melcher, A A, Harrington, K J

“…Oncolytic reovirus is currently under active investigation in a range of tumour types. Early phase studies have shown that this agent has modest monotherapy…”
Get full text

Clinical trials with oncolytic reovirus: Moving beyond phase I into combinations with standard therapeutics by Harrington, K.J, Vile, R.G, Melcher, A, Chester, J, Pandha, H.S

“…Abstract It is time for those working on oncolytic viruses to take stock of the status of the field. We now have at our disposal an array of potential…”
Get full text

Inhibition of the aquaporin 3 water channel increases the sensitivity of prostate cancer cells to cryotherapy by Ismail, M, Bokaee, S, Davies, J, Harrington, K J, Pandha, H

“…Aquaporins ( AQPs ) are intrinsic membrane proteins that facilitate selective water and small solute movement across the plasma membrane. In this study, we…”
Get full text

Synergistic cytotoxicity of radiation and oncolytic Lister strain vaccinia in (V600D/E)BRAF mutant melanoma depends on JNK and TNF-α signaling by Kyula, J N, Khan, A A, Mansfield, D, Karapanagiotou, E M, McLaughlin, M, Roulstone, V, Zaidi, S, Pencavel, T, Touchefeu, Y, Seth, R, Chen, N G, Yu, Y A, Zhang, Q, Melcher, A A, Vile, R G, Pandha, H S, Ajaz, M, Szalay, A A, Harrington, K J

“…Melanoma is an aggressive skin cancer that carries an extremely poor prognosis when local invasion, nodal spread or systemic metastasis has occurred. Recent…”
Get full text

Recent clinical experience with oncolytic viruses by Donnelly, O G, Errington-Mais, F, Prestwich, R, Harrington, K, Pandha, H, Vile, R, Melcher, A A

“…There has been interest in using viruses to treat cancer for over a century. Recent clinical efforts, driven on by significant preclinical advances, have…”
Get more information